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Omega-3 fatty acids prevent gestational diabetes mellitus via modulation of lipid metabolism.
Open Life Sci
August 2024
Department of Gynecology and Obstetrics, Langfang Health Vocational College, South of Siguang Road, Dongfang University Town, Langfang Economic and Technological Development Zone, Langfang, Hebei Province, 065001, China.
Article Synopsis
- The study investigates the effects of omega-3 fatty acids (ω-3 FAs) on gestational diabetes mellitus (GDM) by examining how they influence inflammation and liver function in both cell cultures and animal models.
- ω-3 FAs help convert inflammatory M0 macrophages into anti-inflammatory M2 macrophages, which promotes better liver function and reduces fat buildup, leading to improved blood glucose and insulin levels in pregnant mice with GDM.
- Additionally, the positive impact of ω-3 FAs extends to the offspring of GDM mice, showing decreased birth mortality and improved glycemic control, suggesting a potential treatment strategy for GDM.