resistance in Hainan Province, China: investigating phenotypes and genotypes through whole-genome sequencing.

is increasingly resistant to antibiotics, significantly lowering eradication rates and posing a major public health challenge. This study investigated the distribution of antibiotic-resistant phenotypes and genotypes of in Hainan Province. It determined the minimum inhibitory concentrations (MICs) of six antibiotics using the E-test method and detected resistance genes via Sanger sequencing.

The influence of eight cognitive training regimes upon cognitive screening tool performance in post-stroke survivors: a network meta-analysis.

Background: Traditional meta-analysis offers only direct comparative evidence. The optimal cognitive training for poststroke cognitive impairment (PSCI) remains largely undetermined.

Objectives: This study aims to assess and compare the effectiveness of selected cognitive training methods for PSCI patients and to identify and rank the most effective intervention programs.

Prognostic Nomograms for Elderly Patients with Small Cell Lung Cancer Brain Metastasis: A Surveillance, Epidemiology, and End Results Population-Based Study with Temporal External Validation.

Objective: This study aimed to pinpoint independent predictors influencing overall survival (OS) and cancer-specific survival (CSS) in elderly patients with small cell lung cancer (SCLC) brain metastasis (BM), and to create and validate nomograms for OS and CSS prediction.

Methods: Data from elderly SCLC BM patients were extracted out of the Surveillance, Epidemiology, and End Results database, including 1200 patients identified from 2010 and 2015 who were randomly allocated into a training set and an internal validation set at a proportion of 7:3, and 666 patients diagnosed between 2018 and 2020 as a temporal external validation set. Independent predictors for OS and CSS were determined through univariate Cox analysis, least absolute shrinkage and selection operator analysis, and multivariate Cox analysis sequentially.

polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease, and understanding its genetic and molecular basis is crucial for early diagnosis, treatment, and prevention.

Objective: This study aims to explore the association between polymorphisms (rs2227284, rs2243267, rs2243270, and rs2243283) and RA risk.

Methods: The four polymorphisms were genotyped in 493 RA patients and 493 healthy controls using Agena MassARRAY.

An immunogenic cell death-related lncRNA signature correlates with prognosis and tumor immune microenvironment in bladder cancer.

Immunogenic cell death (ICD) is a newly discovered form of cellular demise that triggers adaptive immune responses mediated by T cells. However, the immunogenic cell death-related lncRNAs (ICDRLs) involved in bladder cancer (BC) development and progression remain to be further elucidated. Molecular profiling data and clinicopathological information for BC patients were obtained from TCGA, and the ICDRGs list was obtained from published literature.

A survey on Helicobacter pylori infection rate in Hainan Province and analysis of related risk factors.

Objective: The aim of this study was to understand the prevalence and potential risk factors of Helicobacter pylori (H. pylori) infection in Hainan Province, China.

Methods: We conducted this study in 21 health service stations in 5 cities of Hainan Province from August 2022 to April 2023.

Development and validation of a simple tool composed of items on dyspnea, respiration rates, and C-reactive protein for pneumonia prediction among acute febrile respiratory illness patients in primary care settings.

Background: Acute febrile respiratory illness (AFRI) patients are susceptible to pneumonia and suffer from significant morbidity and mortality throughout the world. In primary care settings, the situation is worse. Limited by computerized tomography resources and physician experiences, AFRI patients in primary care settings may not be diagnosed appropriately, which would affect following treatment.

The Association between Physical Exercise during Pregnancy and Maternal and Neonatal Health Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Objective: To explore the effect of exercise during pregnancy on the maternal and neonatal health outcomes.

Methods: Eligible papers were systematically retrieved from PubMed, Embase, OVID, and ScienceDirect. Two researchers independently extracted the primary endpoints from the included literature.

Efficacy of Traditional Chinese Medicine Combined with Chemotherapy in the Treatment of Gastric Cancer: A Meta-analysis.

Objective: Meta-analysis was conducted to explore the effects of CM combined with chemotherapy on the effective rate and survival rate of gastric cancer patients.

Methods: Literature retrieval was performed in PubMed, MEDLINE, Embase, CENTRAL, and CNKI databases. The subject of the literature was to compare the efficacy of CM combined with chemotherapy and chemotherapy alone in patients with gastric cancer.

Distinct non-clock-like signatures of the basal cell carcinomas from three sisters with a lethal Gorlin-Goltz syndrome.

Background: Gorlin-Goltz syndrome (GS) is an inherited disease characterized by predisposition to basal cell carcinomas (BCCs) and various developmental defects, whose numerous disease-causing PTCH1 mutations have been identified in the hedgehog (Hh) signaling pathway.

Methods: In this study, whole exome sequencing was used to screen for both somatic and germline deleterious mutations in three sisters with a lethal GS. The mutations we found were confirmed by subcloning and Sanger sequencing of the genomic DNA.

Meta-Analysis of the Effect of Aerobic Training on Blood Pressure in Hypertensive Patients.

Background: We aimed to evaluate the effect of different aerobic training methods and exercise duration on blood pressure in hypertensive patients, including systolic blood pressure (SBP) and diastolic blood pressure (DBP).

Methods: Using the literature review method, the English database PubMed was retrieved to obtain relevant research literature, and the selected studies were analyzed and evaluated.

Results: 14 clinical studies were included in this study, with a total of 1027 patients, including 681 in the aerobic training group and 409 in the control group.

A systematic review and meta-analysis of the effect of transitional care interventions on the prognosis of patients with heart failure.

Background: The purpose of this study was to explore the impact of transitional care interventions on the prognosis of patients with heart failure.

Methods: Literature on transitional care interventions in patients with heart failure were retrieved from PubMed, Medline, Embase, and CENTRAL databases. The literature retrieval date was October 12, 2021.

Effect of hypnosis before general anesthesia on postoperative outcomes in patients undergoing minor surgery for breast cancer: a systematic review and meta-analysis.

Background: Preoperative anxiety is a common phenomenon in breast cancer, causing pain and tension, which is not conducive to the effective surgical treatment and postoperative recovery. It is believed that hypnosis can change the patient's perception of pain, thereby improving the patient's ability to control pain. However, the results of studies for this topic were controversy.

Correlation of clinical features with hs-CRP in TRD patients.

Correlation of clinical features with hypersensitive C-reactive protein (hs-CRP) in patients with treatment-resistant depression (TRD) was investigated. The severity of disease in 103 TRD patients and 103 non-TRD patients was evaluated using the Hamilton Depression Scale (HAMD)-17. The levels of hs-CRP in both groups were detected via immunofluorescence.