[Thromboxane A2: Mechanisms of Synthesis and Intracellular Signaling System of Realization].

One of major complications of ischemic heart disease is myocardial infarction, which develops as a result of thrombosis at the site of ruptured atherosclerotic plaque. Platelets activation and aggregation are the key events of this process. The efficiency of aspirin and/or clopidogrel use is limited by residual platelet reactivity what indicates the need to explore its mechanisms.

[The Development of Pulmonary Damage When Receiving Amiodarone].

In this report we describe in detail a case from clinical practice of the most dangerous side effect of an antiarrhythmic agent amiodarone - amiodarone induced pulmonary toxicity.

[Possibilities to Control Early Stages of Inflammation in and of Thrombus Formation in Cardiovascular Pathology].

Circulating platelet-leukocyte aggregates (PLA) are present in patients with various diseases of the cardiovascular system and are considered as sensitive markers of platelet activation. At the same time characteristics of PLA in the circulating blood continue to be discussed in the context of the search for early markers of inflammation, which would bring us close to ability to limit the development of inflammatory response at the earliest stage. This review is devoted to analysis of studies of LA in the context of assessment of functional activity of platelets and possibilities of cooperation of blood cells during activation of leukocytes at early stage of realization of inflammation process.