[Collis gastroplasty in surgical treatment of hiatal hernia].

Objective: To analyze the early and long-term postoperative outcomes after Collis gastroplasty in the treatment of patients with hiatal hernia complicated by gastroesophageal reflux disease and shortening of the esophagus.

Material And Methods: Postoperative outcomes after Collis gastroplasty were analyzed in 22 patients with hiatal hernia and shortening of the esophagus. The control group consisted of 166 patients after simple repair of hiatal hernia without Collis procedure.

ANALYSIS OF THE DYNAMICS OF FUNCTIONAL OCCLUSION INDICATORS IN THE CONSTRUCTION OF OCCLUSION SURFACES OF ORTHOPEDIC STRUCTURES.

Objective: The aim: Is to evaluate the effectiveness of the proposed method of constructing occlusal surfaces of orthopedic structures by monitoring the dynamics of functional indicators of occlusion and the functional condition of the masticatory muscles.

Patients And Methods: Materials and methods: The object of the study was made up by 64 patients with included defects of the dentition of the 3rd class according to Kennedy. Patients were divided into two equal groups - the main group (patients were treated by using the suggested method of construction of occlusal surfaces of orthopedic structures) and control (dentition defects were replaced according to the traditional protocol).

[Comparative analysis of the stress-strain state of standard and individual reconstructive plates].

Objective: The aim of the study was to analyze a three-dimensional finite element model of a post-resection defect of the lower jaw, design and producing of an individual reconstructive plate, compare the stress-strain of this plate using standard reconstructive «CONMET» plate for stabilizing the lower jaw segments through a simulation of the chewing load.

Material And Methods: The study was carried out on two identical finite elementary models with bone defects in the body of the lower jaw by fixing with a standard reconstructive «CONMET» plate and designed reconstructive plate. In order to simulate the biomechanical loads on the plates when chewing, an impact of force during the occlusal contact of the incisor was applied.

THE CORRELATION OF THE CHEMICAL COMPOSITION OF ENAMEL AND ORAL FLUID IN PATIENTS WITH A WEDGE-SHAPED DEFECT AND INTACT TEETH.

Aim - to determine oral fluid chemical composition and mineralization level in patients with a wedge-shaped defect and intact hard tissues, conduct correlation between the indicators of cervical enamel and oral fluid. We determined Сa2+, РО43-, SO42 using spectrophotometric method, Na+, К+, Al3+ by atomic emission spectrometry, Mg2+, Zn2+ by atomic absorption spectrometry, Cl- using chloride-selective electrode of pH-meter in oral fluid of 22 patients divided into two groups: case - with wedge-shaped defects (2.81+/- 0.

[Antibiotic prophylaxis for infective endocarditis: current approaches].

This review addresses current views on prevention of infectious endocarditis (IE). History of establishing the concept of antibacterial prophylaxis (ABP), major approaches, and substantiation of changes in ABP in recent years are described. Recent international and national guidelines are highlighted, specifically, guidelines of the European Society of Cardiologists, American Heart Association/American College of Cardiology, and the Japanese Circulation Society.

[Risks of progression of cerebrovascular pathology associated with the activity of the brain purinergic system].

Until now, there is no understanding of the relationship between risk factors and the progression of cerebrovascular pathology. The review presents facts that confirm the involvement of various subtypes of purine P2 receptors in neuron activation, growth and myelination of axons, migration and microglia phagocytosis, astrogliosis, regulation of vascular tone, thrombosis and angiogenesis, neuroinflammation and immune responses. The data suggest the possibility of the activation of purinergic system of the brain during the development of main risk factors for cerebrovascular pathology (age, arterial hypertension, diabetes), as a stereotypical mechanism that can affect the homeostasis of the ensemble "neuron-glia-capillary".

Differences in In Vitro Properties of Pancreatin Preparations for Pancreatic Exocrine Insufficiency as Marketed in Russia and CIS.

Background: Pancreatic enzyme-replacement therapy (PERT), provided as pancreatin to patients with pancreatic exocrine insufficiency (PEI), is considered an essential substitute for the pivotal physiological function the pancreas fulfills in digestion. PEI involves a reduction in the synthesis and secretion of pancreatic enzymes (lipase, protease, amylase), which leads to an inadequate enzymatic response to a meal and consequently to maldigestion and malabsorption of nutrients. The efficacy of PERT is strongly dependent on enzyme activity, dissolution, and pancreatin particle size.

THE CAUSES OF ADVERSE TREATMENT RESULTS AND THE WAYS OF THEIR ELIMINATION IN BLEEDING FROM CHRONIC GASTRODUODENAL ULCERS.

Objective: The aim: Is to determine the main causes of adverse outcomes of the patients' treatment with acute ulcerative gastroduodenal bleeding and to develop preventive measures to improve the quality of the patients' treatment with this pathology.

Patients And Methods: Materials and methods: A retrospective analysis of the treatment results of 1323 patients with bleeding of ulcerative etiology has been carried out. There are 375 patients with gastric ulcer (28.

[THE CRANIOMETRIC PARAMETERS AND MORPHOLOGICAL FEATURES OF THE MAXILLA IN THE HUMAN].

The aim of the research was to the study morphological features of the maxilla in people of different ages according to the results of craniometric researches. A craniometric study was performed on 50 bone preparations of the skull with the calculation of the main indices of the skull, including cranial, facial, high-longitudinal, high-latitude, transverse-zygomatic and frontal-zygomatic indices, as well as the main linear parameters of the maxilla - length, width and height. In the studied material, three main morphological types of the structure of the skull are presented: brachycrania (people with round head), mesocrania (people with middle head) and dolichocrania (people with long head).

Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas.

Aim: To study the state of purine metabolism in gastric (GAC) and pulmonary (PAC) adenocarcinomas and to assess its clinical and pathogenetic significance.

Patients And Methods: One hundred and six male patients were examined, among whom were 63 subjects aged 34 to 79 suffering from GAC, and 43 subjects aged 24 to 76 suffering from PAC. In GAC, the ratio of the pyloric, corporeal and antral localization of the tumor and variant of overall gastric lesion accounted to 24:5:1:1; and that of the central and peripheral PAC was 2:1.

; CLINICAL AND LABORATORY CHARACTERISTICS OF ACUTE LYMPHADENITIS IN CHILDREN.

The aim of the study is to determine the clinical and laboratory characteristics of acute lymphadenitis in children.; The study was performed using retrograde analysis of diagnosis and treatment of 158 children with acute lymphadenides of nonspecific and specific etiology, different localization (submandibular, cervical, axillary, inguinal and other peripheral localization) who were treated at the inpatient department in the pediatric surgery of MHCF "Local oncologic dispensary of Kramatorsk" from 2015 to 2019. Among the inpatient children there were 86 (54.

[; THE RESULTS OF APPLICATION OF THE ADVANCED SUPRAGIOID AND SUPRAOMOGIOID NECK DISSECTION IN THE TREATMENT OF REGIONAL METASTASES OF MAXILLOFACIAL AREA CANCER].

The goal of research is to optimize the results of surgical treatment of the regional metastases of the maxillofacial area cancer by improving the technique of supragioid and supraomogioid neck dissection with its variants and substantiate the possibility of their application to the patients with malignant tumors of the maxillofacial area. 104 patients aged 7 to 86 years with malignant tumors of the maxillofacial area were examined, including cancer of the lower lip, oral mucosa, and salivary glands. The patients revealed 187 enlarged regional lymph nodes, which were removed in the course of surgery using advanced methods of supragioid and supraomogioid neck dissection.

Application of neural network technologies in the dental caries forecast.

Objective: The aim: of the work was to develop and apply in the clinical trial a software product for the dental caries prediction based on neural network programming.

Patients And Methods: Materials and methods: Dental examination of 73 persons aged 6-7, 12-15 and 35-44 years was carried out. The data obtained during the survey were used as input for the construction and training of the neural network.

Peculiar features of aortic wall structure among children with coarctation.

Objective: The aim of the study to evaluate the peculiarities of the aortic wall structure at the place of coarctation.

Patients And Methods: Materials and methods: Studying of the aortic sections removed during operative correction at the place of constriction. 10 children at the age between 1 to 6 months were undergone the operation.

Differential diagnostics of inherited metabolic disorders in newborns.

Objective: The aim: To compose an applicable diagnostic checklist for neonatologists, pediatricians, and general practitioners who refer newborns with certain inherited metabolic diseases (IMDs) suspicion to confirmatory testing laboratories.

Patients And Methods: Materials and methods: Analyzed international and generally, known national clinical guides and recommendations devoted to IMDs diagnostics, treatment and follow up.

Results: Results: Considering integral character of the diagnostic work-up of inborn errors of metabolism, authors of this article composed an applicable checklist that comprises set of data necessary for interpretation the positive results of expanded newborn screening and making decision of appropriate biochemical and molecular tests are required for confirmatory follow-up testing to establish the diagnosis and prescribe pathogenetic therapy.

[Mechanisms of chronic stress influence on the brain hemodynamic in persons with employment-related chronic stress].

Objective: To discuss the mechanisms by which chronic psychosocial stress (CPSS) affects the parameters of cerebral blood flow.

Material And Methods: One hundred and sixty locomotive machinists (LM) and machinist assistants (MA), whose profession is rated as one of the most stressful, were enrolled in this study. The control group consisted of 100 healthy volunteers.

Lipofuscin content in the muscle tissue during the early postmortem period: improvement of forensic diagnosis of the prescription of death coming.

Unlabelled: Forensic medicine is naturally supported by fundamental sciences, its integration with them contributing to its improvement on the whole, particularly in diagnosis of the prescription of death coming. Scientific achievements and foreign specialists in forensic medicine during recent years have made it possible to significantly deepen our sound knowledge of postmortem phenomena.

Aim: The aim of the research consisted in study of postmortem regularities in the content of lipofuscin in different types of the muscle tissue (MT) for improving accuracy of determination of prescription of death coming.

The dynamics of changes in biochemical markers of the state of tissue in intercostal muscles during the early postmortem period.

Aim: The aim of study was to evaluate structural and biochemical changes in the tissue of intercostal muscles during the early postmortem period (PMP) - 3-13 hours.

Materials And Methods: Absolute and relative values of the concentration of glycogen, acid phosphatase, lactate, lactate degydrogenase, lipofuscin and cholinesterase during the early PMP were determined on 30 human corpses by results of study of the tissue of intercostal muscles.

Results: It was proved that the early PMP was characterized by proper biochemical and biophysical changes of the muscular tissue, the most demonstrative of them were as follows: a reduction in the concentration of glycogen and dynamic increases in the concentrations of lactate dehydrogenase and lipofuscin.

Genetic polymorphism in patients with early and late onset of ulcerative colitis.

Objective: The aim was to investigate SNPs of TLR-2,3,4, NOD2/CARD15, JAK-2, and IL-10 in patients with the early and late UC onset.

Patients And Methods: Matherials and methods: 126 patients with UC were investigated. To assess the predisposition of the early and late UC onset the incidence of the following SNPs: Arg753Gln TLR2 gene, Phe412Leu TLR3 gene, Asp299Gly and Thr399Ile TLR4 gene, C-819T, G-1082A and C-592A gene IL-10, Val617Phe gene JAK2, Gly908Arg gene NOD2/CARD15 were analyzed.

INVESTIGATION OF RADIATION BACKGROUND IN THE MICRODISTRICTS OF KROPYVNYTSKYI USING DOSIMETER-RADIOMETER MKS-08-01 Gm «DKS-96» AND WIRELESS SENSORS.

Objective: Determine the radiation background in the Kropyvnytskyi microdistricts using the dosimeter-radiometer MKS-08-01 Gm «DKS-96» and a wireless sensor (dosimeter), analyze the measured values using the Student's t-test and create radiation background interactive map of Kropyvnytskyi microdistricts.

Materials And Methods: Measurement of Kropyvnytskyi radiation background was carried out in two ways: using the dosimeter-radiometer MKS-08-01 Gm «DKS-96» to measure the radiation background in the Kropyvnytskyi microdis- tricts (Zavadivka (sanitary zone and observation zone), Kovalivka, Velyka Balka, Lisoparkova, Raion 5/5, Popova, Miskyi sad); using a wireless sensor (dosimeter) with a monitoring system of the area radiation situation on the basis of Wi-Fi module with a microcontroller (Lisoparkova, Zavadivka (sanitary zone and observation zone), Raion 5/5).

Results And Conclusions: Experiment results allowed us to conclude that in some microdistricts of Kropyvnytskyi increased level of radiation pollution.

[Statin-associated muscle symptoms: epidemiology, risk factors, mechanisms and treatment].

Statins are widely prescribed and the risk of adverse drug reactions of lipid-lowering therapy is actively discussed, including muscle symptoms. This review synthesizes the knowledge about the clinical aspects of statin-associated muscle symptoms, which is important for the practitioner. Potential mechanisms of their development, risk factors, clinical manifestations, treatment and prevention are described.

Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency.

The objective of this study was to analyze the current evidence for the use of pancreatic enzyme replacement therapy (PERT) in affecting survival and quality of life in patients with pancreatic exocrine insufficiency (PEI). Systematic searches of the literature were performed using the PubMed database. Articles were selected for inclusion if they reported findings from trials assessing the effects of PERT on quality of life, survival, malabsorption, growth parameters (such as height, body weight and body mass index), or gastrointestinal symptoms (such as abdominal pain, stool consistency and flatulence).