Lectin Receptors in Primary and Metastatic Cancer Cells.

Purpose: The purpose of this study was to detect the distribution of different lectin receptors in primary cancer cells as well as in the case of metastasis, as these biomolecules can potentially predict cancer development in certain tissues and systems.

Methods: To detect lectin receptors in tumors, the authors used conjugates of lectins purified by affinity chromatography with peroxidase, and studied their localization in paraffin sections of 12 cases of primary cancer and 33 of its metastases.

Result: In primary cancers and their metastases, there is a distinct mosaicity in the histotopography of individual lectins, especially peanut and soybean lectin.

Results of microbiological study of dental biofilm in generalized periodontitis against the background of different body reactivity.

Objective: Aim: To study the spectrum, frequency of isolation and level of colonization of dental biofilm with microorganisms in generalized periodontitis against the background of different body reactivity.

Patients And Methods: Materials and Methods: 216 people with the diagnosis of generalized periodontitis. Depending on the state of reactivity of the organism, the patients were divided into 3 groups: with normo-, hyper- and with hyporeaction.

Comparison of D2 vs D3 lymph node dissection for RIght COloN cancer (RICON): study protocol for an international multicenter open-label randomized controlled trial.

Background: Colon cancer is a global health concern, ranking fifth in both new diagnoses and deaths among tumors worldwide. Surgical intervention remains the primary treatment for localized cases, with a historical evolution marked by a focus on short-term outcomes. While Japan pioneered radical tumor removal with a systematic categorization of lymph nodes (D1, D2, D3), the dissemination of Japanese practices to the West was delayed until 90th of last century.

The Use of Pneumocystography for Navigation of Stereotaxic Core-needle Biopsy in Complex Breast Cysts: Case Report.

Complex breast cysts (CBC) are characterized by a high (up to 31.0%) oncological potential and the need for a biopsy. In some clinical situations, navigating a biopsy using mammography (MG), ultrasound (US), endoscopy, and magnetic resonance imaging (MRI) may be difficult.

Risk factors that impact long-term outcomes in sigmoid colon cancer with urinary bladder involvement.

Purpose: This study aimed to identify the risk factors impacting long-term outcomes in patients diagnosed with sigmoid colon cancer with urinary bladder involvement.

Methods: A comprehensive analysis was conducted on a retrospective cohort of 118 patients who underwent multivisceral resection for sigmoid colon cancer with urinary bladder involvement between June 2002 and May 2017. Univariate and multivariate analyses were employed to identify risk factors associated with long-term outcomes.

Neurological disorders in pregnant women in low- and middle-income countries-Management gaps, impacts, and future prospects: A review perspective.

Neurological disorders during pregnancy are a substantial threat to women's health, particularly in low- and middle-income countries. Furthermore, a critical shortage of mental health workers and neurologists exacerbates the already pressing issue, where a lack of coordination of respective healthcare among multidisciplinary teams involved in managing these conditions perpetuates the current state of affairs. Financial restrictions and societal stigmas associated with neurological disorders in pregnancy amplify the situation.

DIFFERENTIAL DRUG CORRECTION CYTOKINE AND PROSTAGLANDIN CONTENT IN BLOOD AND GINGIVAL FLUID IN GENERALIZED PERIODONTITIS AGAINST THE BACKGROUND OF DIFFERENT RESPONSIVENESS OF THE ORGANIZATION.

Objective: The aim is to study the dynamics of prostaglandins and cytokines in the blood and gingival fluid against the background of differential drug correction in patients with generalized periodontitis with different body reactivity.

Patients And Methods: Materials and methods: 216 people aged 45 between 55 years with a diagnosis of generalized periodontitis of II, III degree of severity, chronic course were examined. Depending on the state of reactivity of the organism, the patients were divided into three groups: the first one consisted of people with normoreaction; the second group included patients with hyperreaction; the third group was made up of people with hyporeaction.

HELICOBACTER AND HEPATOBILIARY DISEASES: UPDATE 2023.

•Clinical studies have shown that hepatobiliary diseases of inflammatory and neoplastic origin are associated with Helicobacter infection. •Translocation and the ascending pathway are putative mechanisms for Helicobacter spp to enter the hepatobiliary system. •H.

[Surgical treatment of hiatal hernia complicated by short esophagus: a prospective study].

Objective: To analyze immediate and long-term postoperative results in patients with hiatal hernia complicated by short esophagus.

Material And Methods: We prospectively analyzed postoperative outcomes in 113 patients with hiatal hernia who underwent surgery between 2013 and 2021. The main group consisted of 54 patients with length of intra-abdominal segment of esophagus <4 cm who underwent Collis procedure or esophagus >4 cm and indications for Nissen fundoplication cuff.

DYNAMICS OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN PATIENTS WITH GENERALIZED PERIODONTITIS ACCOMPANIED BY DIFFERENT REACTIVITY OF THE ORGANISM.

The aim of this research was to study the dynamics of pro- and anti-inflammatory cytokines in the blood and gingival fluid of patients with generalized periodontitis accompanied by different reactivity of the body after patch surgery. The study included 216 people aged 45 between 55 years with a diagnosis of generalized periodontitis were examined. Depending on the condition of reactivity of the body, the patients were divided into three groups: 1 - normoreaction; 2- hyperreaction; 3 - hyporeaction.

MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL SIGNS OF PLACENTAL DISORDERS OF WOMEN AFTER SYPHILITIC INFECTION.

Objective: The aim: To define morphological and immunohistochemical signs of placental disorders of women after syphilitic infection.

Patients And Methods: Materials and methods: The prospective study of 60 pregnant women with history of syphilitic infection (main group) and 57 pregnant patients without syphilis (control group) was conducted. The morphological and immunohistochemical study of the afterbirth was performed.

Impact of the Russian Invasion on Mental Health of Adolescents in Ukraine.

Objective: Very limited evidence is available on the psychological impact of war on adolescents in Ukraine. This study compared war experiences and posttraumatic stress disorder (PTSD), anxiety and depression in adolescents living in war-torn and peaceful regions of Ukraine, more than 2 years after Russia first invaded in 2014.

Method: The cross-sectional study included 2,766 students aged 11 to 17 years living in the war-torn Donetsk region and in Kirovograd in central Ukraine.

[Risk factors and mechanisms of acute pyelonephritis development after contact ureterolithotripsy].

Aim: of the study is to identify risk factors for the development of acute pyelonephritis after contact urethrolithotripsy (URLLT) and to establish the mechanisms for maintaining inflammation after the withdrawal of NSAIDs.

Material And Methods: The study included 21 patients who underwent contact ureterolithotripsy (URLT). The severity of leukocyturia was assessed 1 day after URLT, 2 days (the last appointment of NSAIDs, the total duration of the drug was 9 days) and 3 days (24 hours after NSAID discontinuation).

CLINICAL PECULIARITIES OF WOUND HEALING AFTER SURGICAL TREATMENT OF PATIENTS WITH GENERALIZED PERIODONTITIS ACCOMPANIED BY DIFFERENT TYPES OF REACTIVITY OF THE BODY.

Objective: The aim: To study the features of clinical wound healing (intensity and duration of inflammatory reaction) after the indications for patients with generalized periodontitis II, III degrees of severity of patch surgery accompanied by normo-, hyper- and hyporeactivity of the body.

Patients And Methods: Materials and methods: 216 people aged 45 between 55 years with a diagnosis of generalized periodontitis of II, III degree of severity, chronic course were examined. Depending on the condition of reactivity of the organism, the patients were divided into three groups: the first one consisted of people with normoreaction; the second group included patients with hyperreaction; the third group was made up by people with hyporeaction.

ANALYSIS OF RISK FACTORS FOR DENTAL CARIES IN PATIENTS WITH DIABETES MELLITUS.

Objective: The aim: To identify, structure and evaluate the degree of influence of risk factors on the intensity of dental caries in patients with type 1 diabetes mellitus to improve caries-preventive measures.

Patients And Methods: Materials and methods: 179 patients with type 1 diabetes mellitus aged 18 to 56 years with a disease duration from 1 to 50 years were examined. 157 patients had various chronic diabetic complications.

Stereotaxic Core-Needle Biopsy in Assessing Intraductal Pathologic Findings at Ductography.

Objective: The purpose of this study was to analyze the capabilities of ductography (DG) to navigate stereotactic core-needle biopsy (sCNB) for localizing and differentiating intraductal benign and malignant proliferations of the breast in patients with pathological nipple discharge (PND).

Materials And Methods: Patients underwent physical, radiological, ultrasound, endoscopic and histopathological examinations.

Results: The study included 183 patients.

[Assessment of the state of the small intestine microbiota in children on a long-term dairy-free diet].

An overview of recent outcomes of studies indicates an imbalance in the diet of children. Quantitative and qualitative malnutrition of children is the basis of a number of childhood diseases. of the research was to study the prevalence of small intestine bacterial overgrowth syndrome (SIBO) in children on a long-term dairy-free diet.

[Extracellular matrix remodeling as a risk factor for the progression of cerebrovascular pathology].

In recent years, attention of experts has been attracted to remodeling of the brains' extracellular matrix in connection with analysis of alterations' causes of the blood-brain barrier (BBB), development of neuroinflammation and neovasculogenesis, as well as the possibility of regeneration of nervous tissue in cerebrovascular pathology. The review discusses the molecular mechanisms of increasing BBB permeability in stroke associated with the interaction of structural elements of the capillary wall (endothelium and pericytes), glial cells and perivascular leukocytes. The role of brain extracellular matrix remodeling in the pathogenesis of neuroinflammation and participation of pericytes in this process are discussed.

Effectiveness of emergency obstetric care training at the regional level in Ukraine: a non-randomized controlled trial.

Background: Emergency obstetric care training, using Advances in Labour and Risk Management (ALARM) International Program (AIP) was implemented in Ukraine, a country with universal access to skilled perinatal and obstetric care but restricted resources. A total of 577 providers (65.5% of total) from 28 maternal clinics attended a 5-day training session focused on the five main causes of maternal mortality, with hands-on skill workshops, pre- and post- tests, and an objective structured clinical examination.

Development of local treatment approaches for trophic ulcers.

Unlabelled: Trophic venous ulcers are a serious medical and economic issue. Despite a large number of proposed methods for treatment of trophic ulcers, it is not always possible to achieve their complete healing. All this dictates the expediency of further search for more efficient, costeffective and accessible means and methods of trophic ulcer treatment.

DYNAMICS OF ANTI-ANTIOXIDANT SYSTEM INDICATORS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH PERIODONTITIS ACCOMPANIED BY DIFFERENT REACTIVATY OF THE ORGANISM.

Objective: The aim is to study the dynamics of lipid peroxidation and antioxidant protection in the blood of patients with generalized periodontitis accompanied by normo-, hyper- and hyporeactivity of the body after patch surgery.

Patients And Methods: Materials and methods: 216 people aged 45 between 55 years with a diagnosis of generalized periodontitis of II, III degree of severity, chronic course were examined. Depending on the condition of reactivity of the organism, patients were divided into three groups: the first consisted of people with normoreaction; the second included patients with hyperreaction; the third group was made up by people with hyporeaction.

FEATURES OF DENTINE CHEMICAL COMPOSITION OF INTACT TEETH AND TEETH WITH WEDGE-SHAPED DEFECTS.

Objective: The aim: Is to define dentine chemical composition of intact teeth and those with wedge-shaped defects followed by the analysis of revealed differences.

Patients And Methods: Materials and methods: Longitudinal sections of 22 clinically removed teeth (12 - clinically intact ones, 10 - with wedge-shaped defects) from both jaws were studied in patients aged between 25-54 years. JSM-6490 LV focused beam electron microscope (scanning) with system of energy-dispersive X-ray microanalysis INCA Penta FETх3 was used.

Neutrophils and cancers.

Unlabelled: Oncological diseases remain the most important problem of medicine. Causes of cancer, essence of cells malignant transformation process is not revealed, mechanisms of occurrence and development of cancer diseases are not determined. Recent studies show neutrophils are found in close proximity to tumor cells.