Unilateral Purtscher-like retinopathy as the presenting feature of a case with spontaneous carotid artery dissection.

Carotid artery dissection should be considered in the differential diagnosis when a clinician faces with a case presenting with a unilateral Purtscher-like retinopathy.

Evaluation of galectin-3, peptidylarginine deiminase-4, and tumor necrosis factor-α levels in gingival crevicular fluid for periodontal health, gingivitis, and Stage III Grade C periodontitis: A pilot study.

Background: Comparing the gingival crevicular fluid (GCF) levels of galectin-3, peptidylarginine deiminase 4 (PAD4) and tumor necrosis factor-alpha (TNF-α) in individuals with stage III grade C periodontitis and gingivitis and with healthy periodontium was the purpose of this clinical research.

Methods: Sixty systemically healthy and non-smoker individuals consisting of stage III grade C periodontitis (group S3P/n = 20), gingivitis (group G/n = 20), and periodontally healthy (group HP/n = 20) were recruited for this research. Clinical parameters such as probing depth, clinical attachment level, gingival index, plaque index, and bleeding on probing were recorded in periodontal charts.

Parental psychological distress associated with COVID-19 outbreak: A large-scale multicenter survey from Turkey.

Aims: Pandemics can cause substantial psychological distress; however, we do not know the impact of the COVID-19 related lockdown and mental health burden on the parents of school age children. We aimed to comparatively examine the COVID-19 related the stress and psychological burden of the parents with different occupational, locational, and mental health status related backgrounds.

Methods: A large-scale multicenter online survey was completed by the parents ( = 3,278) of children aged 6 to 18 years, parents with different occupational (health care workers-HCW [18.

Retinoic acid signaling and bladder cancer: Epigenetic deregulation, therapy and beyond.

Retinoic acid (RA) signaling is a crucial developmental pathway involved in urothelium development, differentiation and regeneration. Deregulation of the RA signaling is highly implicated in several cancers, including bladder cancer, underlying the need to unravel the complete regulatory aspects of the retinoids in bladder tumorigenesis. Given the fact that RA receptors are transcription factors functioning at the chromatin level and act in close cooperation with chromatin modifiers, it is known that retinoids show their efficacy by changing the epigenome.

Scanning all chromosomal abnormalities with microarray-based comparative genomic hybridization in differential diagnosis of pediatric cancers.

Objective: Despite conventional histopathological and immunohistochemical methods, difficulties may be experienced in the differential diagnosis of pediatric cancers, especially in small round-cell undifferentiated tumors. In these cases, the determination of chromosomal abnormalities may be helpful. The aim of this study was to evaluate the place of the whole genome array comparative genomic hybridization method in pediatric cancers where difficulty is experienced in differential diagnosis.

Risk factors and relationship between screening periodicity and risk of cervical cancer among nurses and midwives. A cross-sectional study.

Background: If nurses and midwives undergo cervical cancer screening regularly, they can become role models for other women regarding this screening.

Objectives: The aims here were (i) to determine factors associated with undergoing cervical cancer screening; and (ii) to examine the association of cervical cancer screening periodicity with cervical cancer risk levels among nurses and midwives.

Design And Setting: Cross-sectional study in a public hospital.

Adaptation of a patient activation measure (PAM) into Turkish: reliability and validity test.

Background: Patient activation is a central concept in chronic illness care model. Activated patients have ability and willingness to manage their health.

Objective: Aim of this study was to test the reliability and validity of a Patient Activation Measure.

The effect on upper extremity functions of cardiac electronic device placement on the dominant hand side.

Background: Although cardiac implantable electronic device (CIED) implantation is considered to be minor surgery, almost 60% of the patients suffer from shoulder-related problems a short time after the procedure. The purpose of this study was to determine the possible effects of the preference of the dominant side for CIED implantation on the ipsilateral superior extremity functions.

Methods: The study included a total of 107 patients who had been living with a CIED for >6 months.

C-Reactive Protein and Platelet-Lymphocyte Ratio as Potential Tumor Markers in Low-Alpha-Fetoprotein Hepatocellular Carcinoma.

The hepatocellular carcinoma (HCC) tumor marker alpha-fetoprotein (AFP) is only elevated in about half of the HCC patients, limiting its usefulness in following the effects of therapy or screening. New markers are needed. It has been previously noted that the inflammation markers C-reactive protein (CRP) and platelet-lymphocyte ratio (PLR) are prognostically important and may reflect HCC aggressiveness.

The mutation p.Gly646Trpfs*12 found in a Turkish boy with Bohring-Opitz Syndrome.

In line with a recent study showing that mutations found in the common population cannot be ruled out as pathogenic, we have identified the p.Gly646Trpfs*12 mutation-present in 132 individuals in ExAC-as a very probable cause of the disease in a Bohring-Opitz syndrome patient.

A Comparison of the Effectiveness of Silibinin and Resveratrol in Preventing Alpha-Amanitin-Induced Hepatotoxicity.

Amanita phalloides species mushrooms containing alpha-amanitin (α-AMA) are responsible for the majority of fatal mushroom intoxications and can lead to severe poisonings resulting in hepatotoxicity and acute hepatic failure. Existing antidotes, such as silibinin, are not sufficiently effective in the prevention and/or resolution of α-AMA-induced hepatotoxicity. We investigated the effects of resveratrol on α-AMA-induced hepatotoxicity and compared with silibinin, a known antidote using in vivo and in vitro toxicity models.

How we eat may be as important as what we eat: eating behaviour and heart rate variability.

Objective Diet exerts a crucial role on cardiovascular health. Evidence is mainly based on the content and the amount of dietary intakes. Some recent reports demonstrated that eating behaviour may also be of significant importance in cardiovascular health.

Rapid identification of and assessment of clarithromycin susceptibility from clinical specimens using FISH.

remains one of the most common bacterial infections worldwide. Clarithromycin resistance is the most important cause of eradication failures. Effective antibiotic therapies in infection must be rapidly adapted to local resistance patterns.

Pesg PNH diagnosis, follow-up and treatment guidelines.

PNH Education and Study Group (PESG) have been established in December 2013 as a non-profit, independent, medical organization www.pesg.org.

Acute Supramaximal Exercise Increases the Brain Oxygenation in Relation to Cognitive Workload.

Single bout of exercise can improve the performance on cognitive tasks. However, cognitive responses may be controversial due to different type, intensity, and duration of exercise. In addition, the mechanism of the effect of acute exercise on brain is still unclear.

Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells.

Lithium is a mood stabilizing agent commonly used for the treatment of bipolar disorder. Here, we investigated the potential neuroprotective effect of lithium against paraquat toxicity and its underlying mechanisms in vitro. SH-SY5Y human neuroblastoma cells were treated with paraquat (PQ) 0.

Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR-20b.

Objective: To identify microRNAs (miRNAs) regulated by anti-α4 integrin monoclonal antibody therapy (natalizumab) in the peripheral blood of patients with relapsing-remitting (RR) multiple sclerosis (MS) and to confirm their role in experimental settings in vivo.

Methods: In a longitudinal study of 17 RR-MS patients, we investigated blood miRNA expression profiles at baseline and after 1 year of natalizumab therapy by microarray technique and quantitative PCR validation. We compared the baseline expression profiles of these patients to those of 18 age- and sex-matched healthy controls.

Smoking status of Turkish nursing students and factors affecting their behavior.

Objective: This descriptive-cross sectional study was conducted in order to determine the smoking status of nursing students and factors affecting their behavior.

Methods: Subjects were 220 students who were selected from all classes of a School of Nursing with a stratified random sampling method and who voluntarily accepted to participate. Permission was obtained both from individuals and the relevant institution to conduct the study.

Evaluation of nursing students' attitudes towards seeking psychological help and factors affecting their attitudes.

Psychological help-seeking means to benefit different sources of support system for the difficulties people have. It is important to find out help-seeking attitudes and factors which affect these attitudes, earlier to protect, and to advance mental health. The aim of this study was to investigate nursing students' attitudes towards seeking psychological help and factors which affect their attitudes.