6,004 results match your criteria: "Dokkyo Medical University.[Affiliation]"

What is the cell of origin of lung neuroendocrine carcinoma?

Respir Investig

December 2024

Department of Pathology, Dokkyo Medical University, 880 Kita-kobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan. Electronic address:

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In September 2023, the Japan Society of Pain Clinicians (JSPC) issued this consensus statement on chronic pain treatment in cancer survivors. With recent advances in the early diagnosis and treatment of cancer, its prognosis has improved, so prolonged pain in cancer survivors is considered to represent chronic pain and should be addressed. In this statement, we emphasize that not all cancer survivor pain is cancer pain.

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Article Synopsis
  • The study aimed to assess the effectiveness and safety of lebrikizumab when combined with topical corticosteroids in Japanese patients aged 12 and older with moderate-to-severe atopic dermatitis (AD).
  • Conducted over 16 weeks, the Phase 3 trial involved 286 participants who were randomly assigned to receive either lebrikizumab (administered every 2 or 4 weeks) or a placebo, with results showing significantly higher rates of improvement in skin condition among those receiving lebrikizumab.
  • The treatment was found to have a good safety profile, with serious adverse events being rare, though some mild to moderate side effects were more common in the lebrikizumab groups compared to the placebo
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  • Peutz-Jeghers syndrome (PJS) and juvenile polyposis syndrome (JPS) are hereditary conditions linked to a high risk of cancer, but their prevalence and incidence in Japan were previously unknown.
  • A nationwide survey in 2022 revealed that there are an estimated 701 patients with PJS and 188 with JPS in Japan, with low prevalence and incidence rates highlighted.
  • Results also showed a higher male representation in both conditions and indicated a need for further research on clinical details and outcomes associated with these syndromes.
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[Sleep Disorders].

No Shinkei Geka

November 2024

Department of Neurology, Dokkyo Medical University.

Article Synopsis
  • Insomnia is a prevalent sleep disorder characterized by trouble falling asleep, staying asleep, or waking up too early, leading to issues functioning during the day.
  • Other types of sleep disorders mentioned include breathing-related issues, movement disorders like restless legs syndrome, and parasomnias such as sleepwalking.
  • The article focuses on various sleep disorders commonly encountered in clinical settings.
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[Laparoscopic Hiatal Hernia Repair].

Kyobu Geka

September 2024

Department of Upper Gastrointestinal Surgery, Dokkyo Medical University, Tochigi, Japan.

Esophageal hiatal hernia is a condition in which the esophageal hiatus opens and the stomach escapes from the abdominal cavity into the mediastinum. The basic surgical procedures are 1) return of the prolapsed stomach into the abdominal cavity, 2) suture of the dilated esophageal hiatus, and 3) fundoplication and fixation of the stomach to prevent gastroesophageal reflux disease (GERD). The Japanese guidelines for the treatment of GERD recommend laparoscopic Toupet fundoplication as the standard procedure, which we also follow.

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[Impella 5.5 Implantation Technique for Surgeons].

Kyobu Geka

September 2024

Department of Cardiovascular Surgery, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.

Article Synopsis
  • The Impella 5.5 is a catheter-based pump that helps support heart function by draining blood from the left ventricle and pumping it to the aorta, functioning as a transcatheter left ventricular assist device (LVAD).
  • Introduced in Japan two years ago, it has been used in around 500 cases, demonstrating its importance in treating severe heart failure.
  • Compared to its predecessor, the Impella 5.0, it offers an increased flow rate and improved durability, making it a valuable tool in mechanical circulatory support.
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Lupus Vulgaris.

Am J Med

November 2024

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Mibu, Tochigi, Japan.

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Background: The general medicine in-training examination (GM-ITE) assesses physicians' clinical knowledge. This study expanded on findings from a previous pilot study to assess the relationship between general medicine in-training examination (GM-ITE) scores and the diagnostic skills of resident physicians in Japan by employing an innovative clinical simulation video (CSV-IE).

Methods: This multicenter cross-sectional study included 4,677 resident physicians who took the GMITE between January 17 and 30, 2023.

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  • The study examines how the preoperative Spine Instability Neoplastic Score (SINS) relates to surgical decisions and patient outcomes in spinal metastases patients.
  • The research involved 317 patients and assessed various factors like surgery type, existing conditions, and postoperative health indicators over 6 months.
  • Findings revealed that SINS did not correlate with life expectancy, all patient-reported outcomes improved post-surgery, and surgical approach (especially fusion vs. non-fusion) didn't significantly impact these outcomes.
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Purpose: General physicians are required to demonstrate diverse leadership skills depending on their environment. It is essential for them to understand the characteristics of the medical institutions to which they belong and put this understanding into practice. Leadership skills are acquired through experience and training, and their acquisition is a goal in various medical training programs.

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Clinical reasoning skills are crucial for physicians. In clinical reasoning conferences using real cases, medical students, residents, and senior residents can follow experts' clinical reasoning processes. However, supervisors may struggle to clearly articulate their clinical reasoning process.

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Background: Anesthetic management of a patient with multiple giant bullae is generally difficult due to an increased risk of respiratory complications, and there is no consensus regarding safe extubation methods. We report a case of an effective use of a supraglottic airway (i-gel™) during emergence from anesthesia in a patient with multiple giant bullae, in whom a double-lumen bronchial tube was being used during anesthesia.

Case Presentation: A 52-year-old man with multiple giant bullae underwent video-assisted pulmonary resections, while the ventilation was controlled via a double-lumen bronchial tube.

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Hemorrhagic strokes are considered as contraindications of extracorporeal membrane oxygenation (ECMO) therapy because of anticoagulant administration and ECMO-associated coagulopathy. We present a rare case of successful microsurgical clipping under ECMO for a poor-grade subarachnoid hemorrhage (SAH) patient with severe neurogenic pulmonary edema (NPE). A 50-year-old man presenting with the sudden loss of consciousness was diagnosed with poor-grade SAH with severe NPE, and was intubated.

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Facilitating Trust Calibration in Artificial Intelligence-Driven Diagnostic Decision Support Systems for Determining Physicians' Diagnostic Accuracy: Quasi-Experimental Study.

JMIR Form Res

November 2024

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu-cho, Shimotsuga-gun, Tochigi, 321-0293, Japan, 81 282-86-1111, 81 282-86-4775.

Background: Diagnostic errors are significant problems in medical care. Despite the usefulness of artificial intelligence (AI)-based diagnostic decision support systems, the overreliance of physicians on AI-generated diagnoses may lead to diagnostic errors.

Objective: We investigated the safe use of AI-based diagnostic decision support systems with trust calibration by adjusting trust levels to match the actual reliability of AI.

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Real-world data on venous thromboembolism (VTE) in Japanese patients with gynecological cancer are lacking. The GOTIC-VTE trial aimed to evaluate the frequency of VTE-associated events and risk factors at the time of cancer diagnosis and during 1-year follow-up. From July 2017 to February 2019, patients with endometrial, cervical, ovarian, tubal, or peritoneal cancer who underwent VTE screening within 2 months before registration, were enrolled.

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Malignant lymphoma is a relatively rare complication in patients with ulcerative colitis (UC) and its etiology is unclear. We present a hard-to-diagnose case of Epstein-Barr virus-positive diffuse large B-cell lymphoma in an elderly patient with UC who was treated with the immunomodulator tacrolimus and herbal medicine including indigo naturalis. Because malignant lymphomas can mimic other inflammatory diseases macroscopically, diagnosis in such cases can be challenging.

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Background: The Scoliosis Research Society-30 (SRS-30) is a questionnaire that was originally developed from the SRS-22r questionnaire and is used to evaluate adolescent idiopathic scoliosis (AIS). It comprises two sections, with Section 1 containing 22 items related to the SRS-22r questionnaire and 1 item regarding self-image and Section 2 containing 7 items specifically related to postoperative status. The SRS-30 has been also found useful in evaluating spinal disorders or deformity in adults.

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Article Synopsis
  • The study aimed to investigate why pregnant women with glucose intolerance often have large infants, focusing on amino and fatty acid transport in the placenta, beyond just glucose transport.
  • Researchers analyzed postpartum placental tissues from 101 eligible deliveries, finding higher expression levels of certain transporters (LAT1 and placenta-FABPpm) in women with glucose intolerance compared to those without.
  • The results suggest that, despite controlled blood sugar levels, managing other nutrients like amino acids and fatty acids in glucose-intolerant pregnancies is crucial for fetal growth.
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  • The study examined how elevated core temperature from heat stress affects aerobic exercise capacity in highly trained athletes compared to just heat exposure without increased core temperature.
  • Seven athletes went through two conditions: one involving elevated core and skin temperatures (HYP) and the other with only elevated skin temperature (SKIN), followed by tasks to induce mental fatigue.
  • Results showed that athletes had shorter exercise time to exhaustion in the HYP condition (about 8.9 minutes) compared to SKIN (around 12.6 minutes), indicating that both high core temperature and mental fatigue negatively impact performance in hot conditions.
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Article Synopsis
  • * The Orbit study aimed to evaluate real-world outcomes for adults with CLL/SLL in Japan treated with ibrutinib between July 2018 and December 2020, including 246 patients in total.
  • * After 36 months, the study showed an 80.9% progression-free survival rate for first-line treatment and 67.2% for relapsed cases, with common significant side effects including bleeding and infections, underscoring ibr
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  • Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition affecting the nasal passages, and this study aims to analyze specific memory B-cells (BRM) in this context.
  • Researchers found that while BRM cells exist in normal sinonasal tissue, their presence is much more pronounced in nasal polyps from CRSwNP patients, as shown through advanced laboratory techniques.
  • This discovery could enhance understanding of immune responses in CRSwNP and pave the way for new treatments, including therapies targeting B-cells.
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Purpose: Artificial intelligence (AI) holds great potential for revolutionizing health care by providing clinicians with data-driven insights that support more accurate and efficient clinical decisions. However, applying AI in clinical settings is often challenging due to the complexity and vastness of medical information. This perspective article explores how AI development methodologies can be adapted to support clinicians in their decision-making processes, emphasizing the importance of a hybrid approach that combines AI capabilities with clinicians' expertise.

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Background: Patients undergoing haemodialysis require long-term treatment and suffer from physical limitations and emotional distress due to restrictions in daily life, such as food and fluid restrictions, which can lead to self-criticism and depression. To address these issues, the concept of self-compassion, which is important for patients undergoing haemodialysis, has gained attention.

Objective: This study aimed to identify self-compassion in patients undergoing haemodialysis.

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