547 results match your criteria: "Division of Neuropsychiatry and Behavioral Neurology; Brown University[Affiliation]"
Genet Med
December 2024
Division of Neurology, Children's Hospital Los Angeles, Los Angeles, CA; Departments of Pediatrics and Neurology, University of Southern California, Los Angeles, CA. Electronic address:
Purpose: Patients with neurodevelopmental disorders (NDDs) have high rates of neuropsychiatric comorbidities. Genomic medicine may help guide care because pathogenic variants are identified in up to 50% of patients with NDDs. We evaluate the impact of a genomics-informed, multidisciplinary, neuropsychiatric specialty clinic on the diagnosis and management of patients with NDDs.
View Article and Find Full Text PDFClin Neuropsychol
December 2024
VA Providence Healthcare System, Center for Neurorestoration and Neurotechnology; Rhode Island Hospital, Division of Neuropsychiatry and Behavioral Neurology; Brown University, Department of Psychiatry and Human Behavior, Providence, RI, USA.
People with functional seizures (FS) have frequent and disabling cognitive dysfunction and mental health symptoms, with low quality of life. However, interrelationships among these constructs are poorly understood. In this meta-analysis, we examined associations between objective (i.
View Article and Find Full Text PDFJ Addict Psychiatry
June 2024
Center for Exercise and Sport Mental Health, Western University Health Sciences, Pomona, USA.
J Neuropsychiatry Clin Neurosci
November 2024
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague (Sojka, Serranová); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, and Laureate Institute for Brain Research, Tulsa, Oklahoma (Khalsa); Functional Neurological Disorder Unit, Division of Behavioral Neurology and Integrated Brain Medicine, Department of Neurology, Division of Neuropsychiatry, Department of Psychiatry, and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston (Perez); Functional Neurological Disorder Unit, Division of Behavioral Neurology and Integrated Brain Medicine, Department of Neurology, Athinoula A. Martinos Center for Biomedical Imaging, and Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston (Diez).
Objective: Research suggests that disrupted interoception contributes to the development and maintenance of functional neurological disorder (FND); however, no functional neuroimaging studies have examined the processing of interoceptive signals in patients with FND.
Methods: The authors examined univariate and multivariate functional MRI neural responses of 38 patients with mixed FND and 38 healthy control individuals (HCs) during a task exploring goal-directed attention to cardiac interoception-versus-control (exteroception or rest) conditions. The relationships between interoception-related neural responses, heartbeat-counting accuracy, and interoceptive trait prediction error (ITPE) were also investigated for FND patients.
Psychiatry Res
December 2024
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Department of Psychiatry, International University of Health and Welfare, Mita Hospital, Tokyo, Japan. Electronic address:
The objective of this study was to reveal the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for Japanese patients with treatment-resistant depression (TRD) in clinical practice, based on real-world data from a nationwide multicenter observational study in Japan. Clinical data of patients with TRD treated with rTMS (NeuroStar TMS treatment system) under public insurance coverage were retrospectively collected from 21 institutes nationwide between June 2019 and December 2023. Depression severity was assessed by the 17-item Hamilton Depression Rating Scale (HAMD-17).
View Article and Find Full Text PDFClin Neuropsychiatry
October 2024
Department of Human Sciences, LUMSA University, Piazza delle Vaschette 101, 00193 Rome, Italy.
Objective: Syncope is defined as a spontaneous and transient loss of consciousness and postural tone due to brief and reversible cerebral hypoperfusion. This review aimed to summarize the research findings regarding the psychological correlates associated with pediatric syncope. Moreover, the study aimed to deepen the understanding of the relationship between psychological disorders and the onset of syncopal episodes in childhood, focusing on clinical features and different clinical classifications.
View Article and Find Full Text PDFMol Psychiatry
November 2024
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Although specific risk factors for brain alterations in bipolar disorders (BD) are currently unknown, obesity impacts the brain and is highly prevalent in BD. Gray matter correlates of obesity in BD have been well documented, but we know much less about brain white matter abnormalities in people who have both obesity and BD. We obtained body mass index (BMI) and diffusion tensor imaging derived fractional anisotropy (FA) from 22 white matter tracts in 899 individuals with BD, and 1287 control individuals from 20 cohorts in the ENIGMA-BD working group.
View Article and Find Full Text PDFEpilepsia
November 2024
Polytrauma Rehabilitation Center, South Texas Veterans Health Care System, San Antonio, Texas, USA.
Objective: To investigate phenotypes of comorbidity before and after an epilepsy diagnosis in a national cohort of post-9/11 Service Members and Veterans and explore phenotypic associations with mortality.
Methods: Among a longitudinal cohort of Service Members and Veterans receiving care in the Veterans Health Administration (VHA) from 2002 to 2018, annual diagnoses for 26 conditions associated with epilepsy were collected over 5 years, ranging from 2 years prior to 2 years after the year of first epilepsy diagnosis. Latent class analysis (LCA) was used to identify probabilistic comorbidity phenotypes with distinct health trajectories.
Nat Genet
November 2024
Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
medRxiv
August 2024
Brain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Mol Psychiatry
September 2024
Medical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Eur Neuropsychopharmacol
January 2025
CNS Discovery Research, Boehringer Ingelheim Pharma GmbH, Biberach, Germany.
J Psychiatr Res
November 2024
Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, NM, USA. Electronic address:
The Global ECT MRI Research Collaboration (GEMRIC) has collected clinical and neuroimaging data of patients treated with electroconvulsive therapy (ECT) from around the world. Results to date have focused on neuroimaging correlates of antidepressant response. GEMRIC sites have also collected longitudinal cognitive data.
View Article and Find Full Text PDFAnn Clin Transl Neurol
November 2024
Department of Pathophysiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Objective: Isolated REM sleep behavior disorder (iRBD) is considered as the strongest predictor of Parkinson's disease (PD). Reliable and accurate biomarkers for iRBD detection and the prediction of phenoconversion are in urgent need. This study aimed to investigate whether α-Synuclein (α-Syn) species in plasma neuron-derived extracellular vesicles (NDEVs) could differentiate between iRBD patients and healthy controls (HCs).
View Article and Find Full Text PDFInt J Environ Res Public Health
July 2024
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94142, USA.
Background: Deployment-related neurotoxicant exposures are implicated in the etiology of Gulf War illness (GWI), the multisymptom condition associated with military service in the 1990-1991 Gulf War (GW). A Q/R polymorphism at position 192 of the paraoxonase (PON)-1 enzyme produce PON1 variants with different capacities for neutralizing specific chemicals, including certain acetylcholinesterase inhibitors.
Methods: We evaluated PON1 status and GW exposures in 295 GWI cases and 103 GW veteran controls.
Psychiatry Clin Neurosci
October 2024
Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Brain Sci
June 2024
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15-90. The effects of dementia, mild cognitive impairment, Parkinson's disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals.
View Article and Find Full Text PDFJ Neurol Neurosurg Psychiatry
July 2024
Functional Neurological Disorder Research Group, Division of Behavioral Neurology & Integrated Brain Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Background: Brain imaging studies investigating grey matter in functional neurological disorder (FND) have used univariate approaches to report group-level differences compared with healthy controls (HCs). However, these findings have limited translatability because they do not differentiate patients from controls at the individual-level.
Methods: 183 participants were prospectively recruited across three groups: 61 patients with mixed FND (FND-mixed), 61 age-matched and sex-matched HCs and 61 age, sex, depression and anxiety-matched psychiatric controls (PCs).
J Alzheimers Dis
August 2024
Division of Psychiatry, University College London, London, UK.
Nat Commun
July 2024
Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
Am J Hum Genet
August 2024
Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Health Innovation Manchester, Manchester, UK; Manchester Centre for Genomic Medicine, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
J Neuropsychiatry Clin Neurosci
July 2024
Department of Neurology (Wiggins, Pharr, Wood, Bateman), Department of Internal Medicine, Division of Gerontology and Geriatric Medicine (Craft, Bateman), Alzheimer's Disease Research Center (Craft, Harrison), Department of Pathology (Harrison, Bateman), and Department of Psychiatry and Behavioral Medicine (Bateman), Wake Forest School of Medicine, Winston-Salem, N.C.; Mental Illness Research, Education, and Clinical Center, Salisbury Veterans Affairs Medical Center, Salisbury, N.C. (Bateman).
Alzheimers Dement
August 2024
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.