2 results match your criteria: "Division of Genetics and Harvard Medical School[Affiliation]"
Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment.
Sci Transl Med
October 2019
Richard King Mellon Foundation Institute for Pediatric Research and Division of Cardiology, UPMC Children's Hospital of Pittsburgh and Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Article Synopsis
- * Analysis of heart tissue from an infant with tetralogy of Fallot with pulmonary stenosis (ToF/PS) showed an increase in cardiomyocyte cytokinesis failure, linked to repression of the ECT2 gene due to β-adrenergic receptor activity.
- * Using β-blockers like propranolol was found to increase cardiomyocyte division, suggesting the potential for these drugs to help improve heart function and recovery in patients with ToF/PS and other forms of CHD.
Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.
FASEB J
July 2014
Program in Genomics, Division of Genetics and Harvard Medical School, Boston, Massachusetts, USA
Previously, we identified family with sequence similarity 65, member B (Fam65b), as a protein transiently up-regulated during differentiation and fusion of human myogenic cells. Silencing of Fam65b expression results in severe reduction of myogenin expression and consequent lack of myoblast fusion. The molecular function of Fam65b and whether misregulation of its expression could be causative of muscle diseases are unknown.
View Article and Find Full Text PDF