108 results match your criteria: "Division of General Internal and Psychosomatic Medicine - Charité-Universitätsmedizin Berlin[Affiliation]"
European Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management.
United European Gastroenterol J
January 2025
Second Department of Internal Medicine and Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Introduction: Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non-gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well-structured approach. If the initial investigation for structural, toxic and metabolic disorders is negative, digestive motility and gut-brain interaction disorders should be assessed.
View Article and Find Full Text PDFData-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.
JAMA Netw Open
November 2024
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.
Article Synopsis
- The study investigates how using small datasets to select an optimal cutoff score for the Patient Health Questionnaire-9 (PHQ-9) can lead to inaccurate results.
- Researchers evaluated whether data-driven methods for cutoff selection resulted in scores that were significantly different from the true population optimal score and if these methods produced biased accuracy estimates.
- Findings showed that many small studies frequently failed to identify the correct optimal cutoff score, particularly in smaller samples, leading to an overestimation of test sensitivity.
The EORTC QLU-C10D distinguished better between cancer patients and the general population than PROPr and EQ-5D-5L in a cross-sectional study.
J Clin Epidemiol
November 2024
Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; BIH Charité Digital Clinician Scientist Program, BIH Biomedical Innovation Academy, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charitéplatz 1 10117, Berlin, Germany.
Objectives: Health state utility (HSU) instruments for calculating quality-adjusted life years, such as the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility - Core 10 Dimensions (QLU-C10D), derived from the EORTC QLQ-30 questionnaire, the Patient-Reported Outcome Measurement Information System (PROMIS) preference score (PROPr), and the EuroQoL-5-Dimensions-5-Levels (EQ-5D-5L), yield different HSU values due to different modeling and different underlying descriptive scales. For example the QLU-C10D includes cancer-relevant dimensions such as nausea. This study aimed to investigate how these differences in descriptive scales contribute to differences in HSU scores by comparing scores of cancer patients receiving chemotherapy to those of the general population.
View Article and Find Full Text PDFGenetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation.
Mol Psychiatry
November 2024
Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Article Synopsis
- The study investigated the CTBP2 gene and its relation to anorexia nervosa (AN) and body mass index (BMI) through mutation analysis, revealing 24 variants in the RIBEYE exon among various groups including patients with AN, obese children, and healthy individuals.
- Three rare non-synonymous variants were found in AN patients, while several variants were unique to children with severe obesity, indicating potential genetic links to these conditions.
- Functional studies showed that RIBEYE mRNA is expressed in the mouse hypothalamus and is influenced by leptin treatment, suggesting that the RIBEYE gene may play a role in body weight regulation.
Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses.
Eur Neuropsychopharmacol
January 2025
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA; The Zucker Hillside Hospital, Northwell Health, New York, USA; Feinstein Institutes for Medical Research, Center for Psychiatric Neuroscience, Manhasset, New York, USA. Electronic address:
Article Synopsis
- The COH-FIT study is a large, multi-country survey aimed at identifying factors affecting wellbeing and mental health outcomes during the COVID-19 pandemic, involving a representative sample of 121,066 adults.
- Researchers analyzed both modifiable (like coping strategies and pre-pandemic stress) and non-modifiable factors (such as age, gender, and socioeconomic status), finding significant negative effects on wellbeing and psychopathology scores during the pandemic.
- The study identified 15 modifiable and 9 non-modifiable risk factors, alongside 13 modifiable and 3 non-modifiable protective factors, emphasizing the importance of social support and coping strategies in mental health outcomes.
Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study.
Psychiatry Res
December 2024
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA; The Zucker Hillside Hospital, Northwell Health, New York, USA; The Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, NY, USA. Electronic address:
Article Synopsis
- There is a lack of comprehensive international studies examining multidimensional mental health and wellbeing before and during the COVID-19 pandemic, particularly identifying at-risk groups and effective coping strategies.
- The COH-FIT survey, conducted from April 2020 to June 2022 in 30 languages, assessed changes in well-being and psychopathology among over 121,000 participants, revealing significant declines in mental health during the pandemic.
- Key findings indicated that certain demographics, such as young adults and people in low-income countries, were particularly affected, while coping strategies like exercise, internet use, and maintaining social contacts emerged as the most effective for managing stress.
Converting PROMIS-29 v2.0 profile data to SF-36 physical and mental component summary scores in patients with cardiovascular disorders.
Health Qual Life Outcomes
August 2024
Department of Psychosomatic Medicine, Center for Patient-Centered Outcomes Research, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Background: Health-related quality of life (HRQL) has become an important outcome parameter in cardiology. The MOS 36-ltem Short-Form Health Survey (SF-36) and the PROMIS-29 are two widely used generic measures providing composite HRQL scores. The domains of the SF-36, a well-established instrument utilized for several decades, can be aggregated to physical (PCS) and mental (MCS) component summary scores.
View Article and Find Full Text PDFGenome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
medRxiv
July 2024
Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, Texas, USA.
Article Synopsis
- * A genome-wide association meta-analysis of nearly 122,000 ANX cases revealed 58 significant genetic variants and 66 related genes, with many of these findings replicated in a larger independent sample.
- * The findings indicate a substantial genetic overlap between ANX and other conditions like depression, emphasizing GABAergic signaling as a key mechanism, thereby enhancing our understanding of the genetic basis of ANX for future research.
Comparison of Patient Health Questionnaire-9, Edinburgh Postnatal Depression Scale and Hospital Anxiety and Depression - Depression subscale scores by administration mode: An individual participant data differential item functioning meta-analysis.
J Affect Disord
September 2024
Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada; Department of Psychiatry, McGill University, Montréal, Québec, Canada; Department of Psychology, McGill University, Montréal, Québec, Canada; Biomedical Ethics Unit, McGill University, Montréal, Québec, Canada.
Article Synopsis
- * Statistically significant differential item functioning (DIF) was found for most questionnaire items, but this had minimal impact on total scores.
- * Researchers and clinicians can choose the administration method based on what works best for patients, considering preferences, feasibility, or cost, as score differences were negligible.
How do mindfulness-based interventions promote coping and self-efficacy in patients with cancer: A systematic review of qualitative and quantitative data.
Psychooncology
May 2024
Psycho-Oncology Division, Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Objective: The purpose of this study was to review the existing quantitative and qualitative evidence regarding how mindfulness-based interventions (MBIs) help cope with cancer-related challenges and increase affected patients' perceived self-efficacy.
Methods: A systematic literature search was conducted on PubMed, PsycInfo, PubPsych, and CINAHL. Quantitative, qualitative, and mixed methods studies were included if they (1) evaluated MBIs (2) for patients with cancer or cancer survivors (3) regarding their impact on coping with cancer and perceived self-efficacy.
Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa.
Sci Rep
March 2024
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstraße 174, 45147, Essen, Germany.
Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (MC4R) gene predispose to a lower BMI. In individuals with reduced body weight, we thus expected mutations leading to an enhanced function in the respective genes, like leptin (LEP) and MC4R.
View Article and Find Full Text PDFPositive Appraisal Style Theory of Resilience posits that a person's general style of evaluating stressors plays a central role in mental health and resilience. Specifically, a tendency to appraise stressors positively (positive appraisal style; PAS) is theorized to be protective of mental health and thus a key resilience factor. To this date no measures of PAS exist.
View Article and Find Full Text PDFImpact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020.
Euro Surveill
January 2024
Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
BackgroundWomen are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well as sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown.AimWe assessed the impact of sex and gender on PASC in a Swiss population.
View Article and Find Full Text PDFInternational Phase IV Field Study for the Reliability and Validity of the European Organisation for Research and Treatment of Cancer Thyroid Cancer Module EORTC QLQ-THY34.
Thyroid
September 2023
Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
The aim of this study was to validate the new European Organisation for Research and Treatment of Cancer Quality of Life Thyroid Cancer Module (EORTC QLQ-THY34). We enrolled 437 thyroid cancer patients from 17 countries. One group ( = 303), undergoing treatment or best supportive care, completed the questionnaires at three time points (before therapy [t1], 6 weeks later [t2], and 6 months after t2 [t3]).
View Article and Find Full Text PDFGenetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa.
Front Genet
April 2023
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Article Synopsis
- - Increased thermogenesis in brown fat could help combat obesity; studies in mice show that gene depletion impacting creatine metabolism affects their ability to regulate body weight when fed high-fat diets.
- - A genome-wide study found a specific SNP (rs1136165) linked to BMI that affects females more significantly than males, with further research identifying various mutations in related genes among different groups of individuals with obesity and anorexia.
- - Evidence suggests that certain genetic variants may protect against obesity, especially in specific types of fat tissue, and further research is required to fully understand the functional implications of these findings.
Lipocalin 2 - mutation screen and serum levels in patients with anorexia nervosa or obesity and in lean individuals.
Front Endocrinol (Lausanne)
April 2023
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Context: The bone-derived adipokine lipocalin-2 is relevant for body weight regulation by stimulating the leptin-melanocortin pathway.
Objective: We aimed to (i) detect variants in the lipocalin-2 gene () which are relevant for body weight regulation and/or anorexia nervosa (AN); (ii) describe and characterize the impact of and variants on circulating lipocalin-2 level.
Methods: Sanger sequencing of the coding region of in 284 children and adolescents with severe obesity or 287 patients with anorexia nervosa.
Comparison of the accuracy of the 7-item HADS Depression subscale and 14-item total HADS for screening for major depression: A systematic review and individual participant data meta-analysis.
Psychol Assess
February 2023
Lady Davis Institute for Medical Research, Jewish General Hospital.
Article Synopsis
- The study compares the effectiveness of two screening tools for major depression: the seven-item Hospital Anxiety and Depression Scale Depression subscale (HADS-D) and the total score of the 14-item version (HADS-T), which includes anxiety items and takes longer to complete.
- An analysis of data from 20,700 participants revealed that both HADS-D and HADS-T had similar sensitivity and specificity for detecting major depression, with optimal cutoffs being ≥7 for HADS-D and ≥15 for HADS-T.
- Overall, while both tools are accurate, the shorter HADS-D is preferred in most clinical settings due to its simplicity and time efficiency.
Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults.
J Affect Disord
April 2023
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; The Zucker Hillside Hospital, Northwell Health, New York, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA; The Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, NY, USA. Electronic address:
Background: The Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic.
View Article and Find Full Text PDFThe serotonin receptor 3E variant is a risk factor for female IBS-D.
J Mol Med (Berl)
November 2022
Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT receptor family. 5-HTRs are encoded by HTR3 genes and control GI function, and peristalsis and secretion, in particular.
View Article and Find Full Text PDFGenome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.
Acta Neuropathol
November 2022
Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Article Synopsis
- Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) offer better insight into Alzheimer's disease (AD) than just clinical diagnosis.
- The European Alzheimer & Dementia Biobank (EADB) analyzed data from 31 cohorts with over 13,000 individuals, identifying new genetic associations such as CR1 for Aβ42 and BIN1 for pTau, alongside novel associations with GMNC and C16orf95.
- Analysis of all AD risk loci revealed four biological categories linked to Aβ42 and pTau, suggesting multiple pathways in AD's development, with further studies indicating GMNC and C16orf95 also relate to brain ventricular volume.
Association of Different Restriction Levels With COVID-19-Related Distress and Mental Health in Somatic Inpatients: A Secondary Analysis of Swiss General Hospital Data.
Front Psychiatry
May 2022
Department of Psychosomatic Medicine, University Hospital and University of Basel, Basel, Switzerland.
Background: The coronavirus disease 2019 (COVID-19) pandemic and related countermeasures hinder health care access and affect mental wellbeing of non-COVID-19 patients. There is lack of evidence on distress and mental health of patients hospitalized due to other reasons than COVID-19-a vulnerable population group in two ways: First, given their risk for physical diseases, they are at increased risk for severe courses and death related to COVID-19. Second, they may struggle particularly with COVID-19 restrictions due to their dependence on social support.
View Article and Find Full Text PDFExamination of the Contributions of Maternal/Placental-Derived Galectin-1 to Pregnancy Outcome.
Methods Mol Biol
March 2022
Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Galectin-1 (gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, is differentially expressed at the feto-maternal interface and appears to be functionally polyvalent, with a wide range of biological activities. However, the contributions of maternal and/or feto-placental gal-1 to the signaling networks promoting a healthy pregnancy are still being elucidated. This chapter discusses the methods commonly employed to study the maternal or feto-placental contribution of gal-1 during pregnancy in mice.
View Article and Find Full Text PDFThe collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic.
J Affect Disord
February 2022
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; The Zucker Hillside Hospital, Northwell Health, New York, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA. Electronic address:
Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed.
Methods: .
External validation of a shortened screening tool using individual participant data meta-analysis: A case study of the Patient Health Questionnaire-Dep-4.
Methods
August 2022
Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada; Department of Psychiatry, McGill University, Montréal, Québec, Canada; Department of Psychology, McGill University, Montréal, Québec, Canada; Department of Educational and Counselling Psychology, McGill University, Montréal, Québec, Canada; Biomedical Ethics Unit, McGill University, Montréal, Québec, Canada.
Shortened versions of self-reported questionnaires may be used to reduce respondent burden. When shortened screening tools are used, it is desirable to maintain equivalent diagnostic accuracy to full-length forms. This manuscript presents a case study that illustrates how external data and individual participant data meta-analysis can be used to assess the equivalence in diagnostic accuracy between a shortened and full-length form.
View Article and Find Full Text PDFPhysical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A).
J Affect Disord
February 2022
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; The Zucker Hillside Hospital, Northwell Health, New York, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA. Electronic address:
Background: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable children and adolescents is crucial.
Methods: The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT - www.