5 results match your criteria: "Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan.[Affiliation]"
Article Synopsis
- The study compares clinical practices and outcomes between elderly patients with ulcerative colitis and those diagnosed at a younger age, noting an increase in older patients with the condition.
- Results showed that elderly-onset ulcerative colitis patients had a significantly lower rate of being free from systemic steroid use and a higher risk of death, whereas surgery and molecular targeting drug rates were similar across both groups.
- Conclusions suggest that while disease severity may be comparable, elderly-onset ulcerative colitis patients face higher mortality risk, highlighting the need for careful monitoring and timely surgical intervention.
Article Synopsis
- The study examines long-term outcomes for patients with new-onset ulcerative colitis (UC) in the age of biologic treatments, using data from 6,689 cases.
- Findings show high rates of being surgery-free (98.5%) and relatively moderate rates for being systemic steroid-free (61.0%) and molecular targeting drug-free (88.7%) five years post-diagnosis.
- The study highlights that younger patients have better surgery-free outcomes, while prescription rates for various treatments have increased significantly from 2014 to 2021, suggesting a potential improvement in long-term UC prognosis.
Article Synopsis
- Acute pancreatitis (AP) is a rare complication of inflammatory bowel disease (IBD), and while studies in the West suggest similar severity to the general population, this is less explored in Eastern countries using biologics.
- This study analyzed data from 1138 AP admissions, comparing IBD patients (divided into ulcerative colitis and Crohn's disease) to those without IBD, finding lower rates of severe AP in IBD groups.
- The results indicated no significant difference in severe AP rates between Crohn's disease patients and non-IBD groups, and the use of biologics did not seem to affect AP severity, suggesting further research is needed.
Article Synopsis
- * Using a nationwide database, researchers compared IBD patients with and without depression, focusing on surgery rates, drug treatments, and in-hospital mortality.
- * Results showed that ulcerative colitis (UC) patients with depression had worse outcomes, suggesting a link between depression and increased disease activity, but causation remains undetermined, necessitating further research.
Background And Aim: The T-cell receptor (TCR) repertoire was assessed in response to various antigens and was considered to be associated with the pathogenesis of inflammatory bowel disease (IBD). Thus, we performed TCR repertoire analysis to examine the pathology of IBD from changes in the TCR repertoire of memory T cells in the intestinal lamina propria mononuclear cells (LPMCs) and peripheral blood mononuclear cells (PBMCs) of patients with IBD.
Methods: LPMCs in the surgical specimens and PBMCs were isolated from 12 patients with IBD (5 patients with ulcerative colitis [UC] and 7 patients with Crohn's disease [CD]).