5 results match your criteria: "Division of Gastroenterology Northwestern University-Feinberg School of Medicine[Affiliation]"

Article Synopsis
  • Chronic constipation is often self-treated with over-the-counter (OTC) laxatives, prompting a systematic review to evaluate their effectiveness and safety.
  • The review analyzed 41 clinical trials and found that polyethylene glycol and senna have strong evidence (grade A) supporting their use as first-line treatments, while other laxatives showed modest support (grade B).
  • Most OTC laxatives were well tolerated, with some common side effects like abdominal pain, cramping, bloating, diarrhea, and nausea noted.
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Introduction: Constipation is commonly treated with over-the-counter (OTC) products whose efficacy and safety remain unclear. We performed a systematic review of OTC therapies for chronic constipation and provide evidence-based recommendations.

Methods: We searched PubMed and Embase for randomized controlled trials of ≥4-week duration that evaluated OTC preparations between 2004 and 2020.

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