5 results match your criteria: "Division of Cardiology University of Pennsylvania Perelman School of Medicine Philadelphia PA USA.[Affiliation]"

In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare professionals involved in catheter or surgical AF ablation. Mounting research evidence and technological advances have resulted in a rapidly changing landscape in the field of catheter and surgical AF ablation, thus stressing the need for regularly updated versions of this partnership which were issued in 2012 and 2017.

View Article and Find Full Text PDF

Precision medicine, which among other aspects includes an individual's genomic data in diagnosis and management, has become the standard-of-care for Mendelian cardiovascular disease (CVD). However, early identification and management of asymptomatic patients with potentially lethal and manageable Mendelian CVD through screening, which is the promise of precision health, remains an unsolved challenge. The reduced costs of genomic sequencing have enabled the creation of biobanks containing in-depth genetic and health information, which have facilitated the understanding of genetic variation, penetrance, and expressivity, moving us closer to the genotype-first screening of asymptomatic individuals for Mendelian CVD.

View Article and Find Full Text PDF
Article Synopsis
  • Myocardial infarction from spontaneous coronary artery dissection (SCAD) can lead to significant psychological issues, including posttraumatic stress disorder (PTSD), affecting many patients' quality of life.
  • In a study involving 1,156 SCAD patients, nearly 35% had experienced probable PTSD at some point, but a significant portion had not sought treatment for their symptoms.
  • Factors such as younger age at first SCAD, being single, and having a history of anxiety were linked to higher PTSD symptom severity, highlighting the need for better screening and treatment connections for affected individuals.
View Article and Find Full Text PDF

Background: Identifying novel molecular drivers of disease progression in heart failure (HF) is a high-priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma proteins and adverse outcomes in HF and their putative causal role using Mendelian randomization.

Methods And Results: The authors measured 4776 plasma proteins among 1964 participants with HF with a reduced left ventricular ejection fraction enrolled in PHFS (Penn Heart Failure Study).

View Article and Find Full Text PDF
Article Synopsis
  • * A study was conducted to integrate a nonfasting lipid test into routine prenatal care, which resulted in 66% of patients completing the screening within six months.
  • * Outcomes showed that 25% of the tested patients had abnormal results, highlighting the need for improved health system processes to support lipid screening and follow-up care.
View Article and Find Full Text PDF