International Society on Thrombosis and Haemostasis Clinical Practice Guideline for Treatment of Congenital Haemophilia-A Critical Appraisal.

Introduction: Evidence-based clinical practice guidelines drive optimal patient care and facilitate access to high-quality treatment. Creating guidelines for rare diseases such as haemophilia, where evidence does not often come from randomized controlled trials but from non-randomized and well-designed observational studies and real-world data, is challenging. The methodology used for assessing available evidence should consider this critical fact.

Detection of Illegally Manufactured Fentanyls and Carfentanil in Drug Overdose Deaths - United States, 2021-2024.

During 2023, approximately 72,000, or nearly seven in 10, drug overdose deaths in the United States were estimated to involve illegally manufactured fentanyls (IMFs). Carfentanil, a fentanyl analog 100 times more potent than fentanyl, has reemerged in the U.S.

Piriform cortex is an ictogenic trigger zone in the primate brain.

Objective: Area tempestas, a functionally defined region in the anterior piriform cortex, was identified as a crucial ictogenic trigger zone in the rat brain in the 1980s. However, whether the primate piriform cortex can trigger seizures remains unknown. Here, in a nonhuman primate model, we aimed to localize a similar trigger zone in the piriform cortex and, subsequently, evaluated the ability of focal inhibition of the substantia nigra pars reticulata (SNpr) to suppress the evoked seizures.

Ethics Consultation in U.S. Pediatric Hospitals: Adherence to National Practice Standards.

Background: The American Society for Bioethics and Humanities (ASBH), a professional organization that certifies ethics consultants who pass the qualifying examination, published standards for the conduct of ethics consultations (EC). A national survey of adult hospital ethics consultants identified adherence to these standards, but no assessment of pediatric hospitals' adherence has been done.

Methods: In this cross-sectional study, a national questionnaire was distributed electronically in 2022 to pediatric ethics consultants at children's hospitals, collecting information about adherence to the ASBH standards.

Temporal trends in online searches related to COVID-19 vaccine safety: A digital infodemiology study.

Background: The rapid development of COVID-19 vaccines may have raised public concerns about their safety and side effects in the United States (US). This study aimed to assess trends in online searches related to the safety and side effects of COVID-19 vaccines in the US from 2021-2022.

Methods: Google COVID-19 Vaccination Search Insights was used to analyze searches about COVID-19 vaccine safety and side effects in the US from January 4, 2021, to November 21, 2022 (98 weeks).

Expanding the complex: phylogenomic insights, proposal of sp. nov. and reclassification of two species.

A novel species was isolated as a contaminant in viral transport media at the District of Columbia Department of Forensic Sciences Public Health Laboratory. Phylogenomic and biochemical analyses of the isolate determined that it represented a novel species within . Related strains in public genome databases suggested that this novel species is associated with clinically acquired infections, similar to closely related .

Quality of life and the patient journey in hidradenitis suppurativa.

Hidradenitis suppurativa is a debilitating inflammatory disease with a profound impact on quality of life for affected patients and caregivers. The patient journey in hidradenitis begins with symptom onset and proceeds through diagnosis and treatment. It is fraught with misdiagnosis, lack of awareness, misinformation, and inappropriate treatments that lead to shame, blame, isolation, and medical mistrust.

Selective small molecule inhibitors for hidradenitis suppurativa: Today and tomorrow.

Hidradenitis suppurativa (HS) is an autoinflammatory condition characterized by abscesses, inflammatory nodules, and tunnels in intertriginous sites of the body. The pathogenesis of HS involves follicular occlusion in combination with environmental, genetic, hormonal, and metabolic factors. HS lesions are characterized by an influx of neutrophils, histiocytes, B and T cells, and upregulation of proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1, interleukin-17, and interferons.

Variation in whale (Cetacea) inner ear anatomy reveals the early evolution of "specialized" high-frequency hearing sensitivity.

As fully aquatic mammals, hearing is arguably the most important sensory component of cetaceans. Increasingly, researchers have been harnessing computed tomography (CT) to investigate the details of the inner ear as they can provide clues to the hearing abilities of whales. We use microCT scans of a broad sampling of the ear bones (periotics) of primarily toothed whales (Odontoceti) to investigate the inner ear bony labyrinth shape and reconstruct hearing sensitivities among these cetaceans, including several taxa about which little is currently known.

Optimizing nurse practitioner productivity within the Veterans Health Administration.

Background: Nurse practitioners (NPs) provide high-quality, comprehensive health care at Veterans Health Administration (VHA) medical centers in various practice settings. Accurately determining the productivity of NPs is essential to understanding their overall contribution to veteran care. There is a lack of understanding of the contributors to the variability among VHA medical centers regarding their processes for capturing these data.

Clinical characteristics and outcome of central nervous system tumors harboring NTRK gene fusions.

Purpose: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.

Experimental Design: We conducted an international retrospective cohort study of patients with TRK fusion-driven CNS tumors.

Perioperative Use of Systemic Steroids Within Otolaryngology-Head and Neck Surgery: Evidence-Based Guidance for Clinicians.

Objective: To review and synthesize the available evidence for use of perioperative systemic steroids for otolaryngologic surgical procedures.

Data Sources: A comprehensive literature review with evidence-informed recommendations.

Review Methods: Databases were queried for medical subject heading terms and keywords related to perioperative systemic corticosteroids use for comprehensive otolaryngology and subspecialty procedures including otologic, sinonasal, sleep, laryngeal, head and neck, facial plastics, and pediatric surgery.

Contextualizing prophylactic red blood cell antigen matching in the lifelong care of sickle cell disease and thalassaemia patients.

Alloimmunization to minor red blood cell antigens has been linked to patient morbidity and mortality, especially among people living with sickle cell disease and transfusion-dependent thalassaemia. Prophylactic antigen matching is commonly used to prevent alloimmunization, but the evidence supporting this common practice is very limited. The report by Wolf et al.