1,980 results match your criteria: "Dipartimento di Scienze Cliniche[Affiliation]"

Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a systematic literature review and experts' consensus.

Autoimmun Rev

September 2024

Rheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", 00128 Rome, Italy; Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.

Inflammatory rheumatic diseases are different pathologic conditions associated with a deregulated immune response, codified along a spectrum of disorders, with autoinflammatory and autoimmune diseases as two-end phenotypes of this continuum. Despite pathogenic differences, inflammatory rheumatic diseases are commonly managed with a limited number of immunosuppressive drugs, sometimes with partial evidence or transferring physicians' knowledge in different patients. In addition, several randomized clinical trials, enrolling these patients, did not meet the primary pre-established outcomes and these findings could be linked to the underlying molecular diversities along the spectrum of inflammatory rheumatic disorders.

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Objectives: We aimed to evaluate ixekizumab (IXE) effectiveness, drug survival and clinical response predictors in moderate-severe psoriatic arthritis (PsA) patients in different clinical scenarios.

Methods: This was a multicentre real-life observational study based on Gruppo Italiano Studio Early Arthritis (GISEA) registry of IXE treatment in PsA patients (January 2019-June 2023). Data were collected at baseline and every six months.

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Background: A sex-based evaluation of prognosis in heart failure (HF) is lacking.

Methods And Results: We analyzed the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score registry, which includes HF with reduced ejection fraction (HFrEF) patients. A cross-validation procedure was performed to estimate weights separately for men and women of all MECKI score parameters: left ventricular ejection fraction (LVEF), hemoglobin, kidney function assessed by Modification of Diet in Renal Disease, blood sodium level, ventilation vs.

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[The physical activity paradox.].

Recenti Prog Med

July 2024

Centro di Biostatistica, epidemiologia e sanità pubblica (C-Beph), Dipartimento di Scienze cliniche e biologiche, Università di Torino.

Recent discoveries have shown that the effects of physical activity on health are not the same in all its domains. In particular, the health effects of physical activity differ not only in terms of modality and intensity, but also based on the context in which it is carried out. Several studies have observed that those who do a lot of physical activity at work tend to have worse health outcomes than those who do less physical activity at work but more exercise in their free time.

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Bridging the gender gap in cardiovascular research: The role of cognitive biases in selection bias in clinical trials.

Int J Cardiol

October 2024

Istituti Clinici Scientifici Maugeri IRCCS, Milano Camaldoli, Italy; Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, Università degli Studi di Milano, Italy.

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Background: the study of the possible determinants of the rise and fall of infections can be of great relevance, as was experienced during the COVID-19 pandemic. One of the methods to understand whether determinants are simultaneous or develop through contiguity between different areas is the study of the diagnostic replication index RDt among regions.

Objectives: to introduce the analysis of RDt variability and the subsequent application of a recently introduced functional clustering method as highly useful procedures for recognizing the presence of clusters with similar trends in epidemic curves.

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Background: Ensuring equitable access to adequate standard of care for patients with rare hematological disease is one of the aims of the European Reference Network (ERN) EuroBloodNet. Stroke is one of the most devastating complications for children with sickle cell disease (SCD). For effective prevention of stroke risk, annual transcranial Doppler (TCD) according to a defined protocol is recommended for patients aged 2-16 years, with red blood cell transfusion therapy for those at risk.

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Clinical, histologic, and immunologic signatures of Small Fiber Neuropathy in Systemic Lupus Erythematosus.

J Peripher Nerv Syst

September 2024

Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Lupus Clinic, Rheumatology, Sapienza Università di Roma, Rome, Italy.

Background And Objectives: Systemic Lupus Erythematosus (SLE) often causes damage to small nerve fibers, leading to distressing painful and autonomic symptoms. Despite this, Small Fiber Neuropathy (SFN) remains an underrecognized complication for SLE patients. In this cross-sectional study, we aimed to assess SFN in patients with SLE and to explore its correlations with immunologic disease features and clinical manifestations.

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Article Synopsis
  • Giant cell arteritis (GCA) is a disease that mostly affects people over 50 and can cause serious health problems like loss of vision or strokes.
  • Current ways to diagnose GCA, like taking a biopsy or using ultrasound, have some limitations, and scientists are looking for new methods to help.
  • This study discovered specific antibodies that could help diagnose GCA more easily, which might improve how doctors identify and treat this disease in the future.
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Patent foramen ovale (PFO) is often diagnosed in patients with cryptogenic stroke, aged > 60-65 years, but few data report the outcomes of PFO closure in elderly patients. Consecutive patients undergoing PFO closure at a single institution between January 2006 and December 2011 were included. Baseline clinical features and cerebral imaging data were collected, and a RoPE score was calculated for each patient.

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The role of anxiety is unknown in relation to postpartum bonding, unlike the well-known detrimental effect that postpartum depression has on the relationship between a mother and child. This study investigates how anxiety affects mother-infant bonding after childbirth, comparing the Italian version of the Postpartum Specific Anxiety Scale (PSAS-IT) with generalized measures of anxiety. Examining 324 non-randomly-selected participants responding to various scales, including the Edinburgh postnatal depression scale (EPDS), generalized anxiety disorder (GAD), postpartum-specific anxiety scale (PSAS-IT), postpartum bonding questionnaire (PBQ), and baby care questionnaire (BCQ-2), initial results suggest a link between certain postpartum anxiety symptoms and attachment problems.

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Screening for antenatal maternal depression: comparative performance of the Edinburgh Postnatal Depression Scale and Patient Health Questionnaire-9.

Ann Ist Super Sanita

June 2024

Centro di Riferimento per le Scienze Comportamentali e la Salute Mentale, Istituto Superiore di Sanità, Rome, Italy.

Background: Maternal antenatal depression affects 21-28% of expectants globally and negatively impacts both maternal and child health in the short and long term.

Objective: To compare the psychometric properties and clinical utility of the Edinburgh Postnatal Depression Scale (EPDS) and the Patient Health Questionnaire (PHQ-9) in pregnant individuals.

Methods: In this cross-sectional study, 953 third-trimester pregnant Italian individuals completed both the EPDS and the PHQ-9.

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Cardiovascular (CV) diseases account for over 4 million deaths every year in Europe and over 220 000 deaths in Italy, representing the leading cause of morbidity and mortality worldwide. The European Society of Cardiology (ESC) guidelines have visionary included in the at very high CV risk group patients without previous acute ischemic events, such as those with subclinical atherosclerosis, chronic coronary syndrome or peripheral arterial disease, familial hypercholesterolemia, diabetes mellitus with target organ damage or multiple associated risk factors, and those with high calculated CV risk score, recommending to consider them and to achieve the same LDL-cholesterol targets as for secondary prevention patients. The aim of this position paper is to provide an updated overview of ESC guidelines that focuses on these patient categories to raise awareness within the clinical community regarding CV risk reduction in this specific epidemiological context.

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Article Synopsis
  • Pregnancy is a significant challenge for a woman's heart and blood system, and having pre-existing heart issues or metabolic problems can lead to bad outcomes during pregnancy and increase the risk of heart diseases later on.
  • The health environment provided by the mother can impact the cardiovascular well-being of the child, as factors during pregnancy can affect the child's growth and future heart health.
  • This review discusses the latest insights on how both mothers and their unborn children influence cardiovascular health, emphasizing prevention strategies throughout different stages of life.
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Article Synopsis
  • * Lombardy, Italy is setting up specialized pancreas units to centralize complex care in high-volume hospitals, using a collaborative model that involves various stakeholders to enhance clinical outcomes.
  • * The initiative aims to create structured criteria for care, including surgery and other essential treatments, providing a framework that could be adapted by other regions and countries to strengthen their cancer care systems.
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Impact of in vitro SARS-CoV-2 infection on breast cancer cells.

Sci Rep

June 2024

Microambiente e Biomarcatori dei Tumori Solidi, Dipartimento di Oncologia Sperimentale, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Amadeo 42, 20133, Milan, Italy.

The pandemic of coronavirus disease 19 (COVID-19), caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), had severe repercussions for breast cancer patients. Increasing evidence indicates that SARS-CoV-2 infection may directly impact breast cancer biology, but the effects of SARS-CoV-2 on breast tumor cells are still unknown. Here, we analyzed the molecular events occurring in the MCF7, MDA-MB-231 and HCC1937 breast cancer cell lines, representative of the luminal A, basal B/claudin-low and basal A subtypes, respectively, upon SARS-CoV-2 infection.

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Introduction: Functional connectivity (FC) is defined in terms of temporal correlations between physiological signals, which mainly depend upon structural (axonal) connectivity; it is commonly studied using functional magnetic resonance imaging (fMRI). Interhemispheric FC appears mostly supported by the corpus callosum (CC), although several studies investigating this aspect have not provided conclusive evidence. In this context, patients in whom the CC was resected for therapeutic reasons (split-brain patients) provide a unique opportunity for research into this issue.

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[The peer-review process: critical issues and challenges from an online survey].

Epidemiol Prev

May 2024

UOC Epidemiologia Ambientale, Occupazionale e Registro Tumori, Dipartimento di Epidemiologia del Servizio Sanitario Regionale della Regione Lazio, ASL Roma 1, Roma.

Background: the peer-review process, which is the foundation of modern scientific production, represents one of its essential elements. However, despite numerous benefits, it presents several critical issues.

Objectives: to collect the opinions of a group of researchers from the epidemiological scientific community on peer-review processes.

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Patients affected by heart failure (HF) with reduced ejection fraction (HFrEF) are prone to experience episodes of worsening symptoms and signs despite continued therapy, termed "worsening heart failure" (WHF). Although guideline-directed medical therapy is well established, worsening of chronic heart failure accounts for almost 50% of all hospital admissions for HF with consequent higher risk of death and hospitalization than patients with "stable" HF. New drugs are emerging as cornerstones to reduce residual risk of both cardiovascular mortality and readmission for heart failure.

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Objectives: occupational exposure to vapours, gases, dusts and fumes (VGDF) plays an important role in the development and exacerbation of respiratory diseases. The aim of this study is to evaluate the possible association of occupational exposure to airborne pollutants and chronic respiratory diseases.

Design: multicase-control study.

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Article Synopsis
  • The study evaluated the effectiveness and safety of filgotinib, a medication for rheumatoid arthritis (RA), using data from the Italian GISEA registry.
  • In a cohort of 246 RA patients, significant improvements in disease activity and pain levels were observed after 3 and 12 months of treatment, with retention rates of 84.5% at 6 months and 75.8% at 12 months.
  • Overall, filgotinib was found to be safe and effective, with a higher risk of discontinuation in difficult-to-treat RA patients compared to those who were new to biologic treatment.
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Fibromyalgia and the Difficult Synthesis.

J Rheumatol

June 2024

M. Di Carlo, MD, B. Bianchi, MD, F. Salaffi, MD, PhD, Rheumatology Unit, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Jesi, Ancona, Italy.

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Gliomas are among the most fatal tumors, and the available therapeutic options are very limited. Additionally, the blood-brain barrier (BBB) prevents most drugs from entering the brain. We designed and produced a ferritin-based stimuli-sensitive nanocarrier with high biocompatibility and water solubility.

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