3 results match your criteria: "Dip. Farmacologia Preclinica e Clinica[Affiliation]"

Interest in the histaminergic system as a potential target for the treatment of feeding disorders is driven by the unsatisfactory history of the pharmacotherapy of obesity. Eating behavior is regulated by a complex interplay of central neurotransmitter systems, peripheral endocrine stimuli, the circadian rhythm, and environmental cues, all factors that change the behavioral state and alter homeostatic aspects of appetite and energy expenditure. Key factors driving eating behavior are appetite and satiety that are regulated through different mechanisms.

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NeuroWatch.

Neuroreport

January 2002

Sobell Research Department of Motor, Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG; Institute of Neurology, University College of London, London, UK Dip. Farmacologia Preclinica e Clinica, Viale Pieraccini 6, 50139 Firenze, Italy, e-mail address: Institute of Coginitive Neuroscience, University College London, Queen Square, London, UK,

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The incubation of xanthine-oxidase (XOD) with rat cardiac membranes induced the formation of free radicals; they were identified by electron spin resonance spectroscopy (ESR) studies using 0.1 M 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) for spin-trapping. The following DMPO adducts were measured: DMPO-OH, which was produced during the first minute of incubation, DMPO-R radicals, which were present after 4 min of incubation and where the signal intensity remained constant for at least 20 min.

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