4 results match your criteria: "Digestive System Department. La Mancha-Centro Hospital Complex. Alcázar de San Juan[Affiliation]"
Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology.
Allergy
October 2023
Molecular Biology Unit, Hospital Universitario de la Princesa, Madrid, Spain.
Article Synopsis
- Eosinophilic esophagitis (EoE) is a chronic allergic disease affecting the esophagus, and researchers used proteomics and RNA sequencing to study changes in the esophageal tissue of EoE patients compared to healthy controls.
- Out of 1667 identified proteins, 363 were differentially accumulated in EoE, while RNA sequencing revealed 1993 differentially expressed genes, highlighting a significant correlation between RNA and protein levels, especially for certain mRNA-protein pairs.
- The study provided new insights into the pathogenesis of EoE, revealing alterations in immune responses and epithelial processes, and emphasized the importance of combining proteomic and transcriptomic data for a better
Long-Term Anorectal Manometry Outcomes After Laparoscopic and Transanal Total Mesorectal Excision.
J Laparoendosc Adv Surg Tech A
April 2021
Department of Surgery, La Mancha Centro General Hospital, Alcázar de San Juan, Spain.
During transanal total mesorectal excision (TaTME), sustained dilation of the anal canal occurs, which can cause anatomical and functional damage to the sphincter complex. This study aimed to analyze the impact of laparoscopic total mesorectal excision (LaTME) and TaTME in anorectal sphincter function. An observational study was conducted comparing two cohorts of patients who underwent LaTME or TaTME for rectal cancer.
View Article and Find Full Text PDFArticle Synopsis
- Fecal calprotectin (FC) is a noninvasive marker of gut inflammation linked to Crohn's disease severity, but its effectiveness in predicting postoperative recurrence remains uncertain.
- In a study of 86 patients after ileocolonic resection, FC levels were higher in those with endoscopic recurrence, yet its sensitivity and specificity were lower compared to a combination of C-reactive protein (CRP) and the Harvey-Bradshaw index (HBI).
- Ultimately, the research concluded that using CRP along with HBI yields better predictive accuracy for endoscopic postoperative recurrence than relying solely on FC.
Management of HCV infection in chronic kidney disease.
Nefrologia
October 2011
Digestive System Department. La Mancha-Centro Hospital Complex. Alcázar de San Juan, Ciudad Real, Spain.
The prevalence of chronic infection with the hepatitis C virus (HCV) in patients with chronic kidney disease is higher than in the general population. The estimated prevalence is 13% in haemodialysis, with wide variations geographically and between units in the same country. A liver biopsy is a useful tool for deciding whether to start antiviral therapy and to exclude concomitant causes of liver dysfunction.
View Article and Find Full Text PDF