497 results match your criteria: "Dicle University Faculty of Medicine[Affiliation]"

Background: Intracranial hemorrhage (ICH) is reportedly rare but has high morbidity and mortality risk in persons with hemophilia. Although the risk factors that facilitate bleeding are known, the factors affecting the sequelae are not well known.

Objectives: We planned to investigate the risk factors for neurologic sequelae in children and adolescents with hemophilia suffering from ICH.

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Background: Hospitals, being establishments with varying functions and capacities, must have disaster plans that reduce vulnerability, ensure the continuity, and possibly increase the capacity of healthcare services; these measures are crucial for reducing mortality and facilitating the normalization of life after a disaster. In this study, the aim was to analyze the operational process of the disaster management plan at Dicle University Faculty of Medicine Hospital following the earthquake in Kahramanmaraş on 6 February 2023.

Methods: This is a retrospective observational study.

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In Türkiye, anti-tobacco legislation (Law No. 4207 on the Prevention and Control of Harms of Tobacco Products) aims to ensure a "tobacco-free" life for current and future generations. However, there are observations of violations in the hospitality sector.

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Introduction: Placenta previa and Placenta Accreta Spectrum are life-threatening obstetric conditions that are challenging to diagnose accurately. Currently, there is no biochemical parameter available for their diagnosis. The aim of our study is to investigate the potential of Elabela as a laboratory marker that could predict placenta previa and placenta accreta, both of which can lead to severe, life-threatening complications for the mother.

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Objective: This study aimed to explore the relationship between fluorine-18-fluorodeoxyglucose (F-FDG) uptake in the liver, spleen, and bone marrow and inflammatory markers such as c-reactive protein (CRP), albumin, and erythrocyte sedimentation rate (ESR) in patients undergoing positron emission tomography/computed tomography (PET/CT) imaging for cancer diagnosis.

Subjects And Methods: This retrospective cross-sectional study included a total of 708 patients with a diagnosis of malignancy. Fluorine-18-FDG PET/CT images acquired between January 2021 and December 2022.

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Purpose: The limitations in cancer treatment and the inadequacy of classical methods have made it necessary to discover therapeutics in cancer treatment. The cytotoxicity of thymoquinone, which has quite different properties in terms of biological activities, in ovarian cancer cells, and the changes in the expression levels of apoptotic genes (p53/caspase-3 (casp-3)) were investigated.

Methods: In the study, thymoquinone (5, 50, 100, 250 and 500 µM and 24, 48, 72 hours) were applied to ovarian adenocarcinoma cancer cell line (OVCAR3), at different concentrations.

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Background/objectives: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with an increased risk of obesity and disordered eating behaviors. This study compared weight status and eating behaviors among drug-naïve ADHD children, those on stimulant monotherapy, those on combined stimulant and antipsychotic treatment, and healthy controls.

Methods: This cross-sectional study included 547 children aged 6-12 years from four Turkish provinces: 361 with ADHD (152 drug-naïve, 156 on stimulants, and 53 on combined therapy), and 186 healthy controls.

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Objectives: Current guidelines suggest that patients with cystic fibrosis (CF), who are over the age of 10, should be annually evaluated with oral glucose tolerance test (OGTT). In this study, it was aimed to evaluate the OGTT results in patients above the age of 10, who were followed up in our center with the diagnosis of CF.

Methods: In the study, 46 patients with CF at the age of 10 and above, who underwent OGTT were included.

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Common viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter study from Türkiye.

Turk J Pediatr

October 2024

Department of Pediatric Hematology Oncology, Yıldırım Beyazıt University Faculty of Medicine, Ankara Bilkent City Hospital, Ankara, Türkiye.

Article Synopsis
  • During the COVID-19 pandemic lockdown, the study assessed respiratory viral infections in children with cancer, highlighting their clinical impact.
  • Of the 265 episodes evaluated, human rhinovirus/enterovirus was the most common pathogen identified, with significant complications noted, including a higher rate of lower respiratory tract infections.
  • The findings emphasize the necessity for quicker detection and treatment of respiratory viruses to prevent severe outcomes in this vulnerable population.
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Purpose: Napabucasin (NP) is a natural compound that can suppress cancer cell proliferation and cell cycle by inhibition of the signal transducer and activator of transcription 3 (STAT3) gene. We examined the effects of NP on the proliferation and invasion of neuroblastoma cells (SH-SY5Y).

Methods: Human neuroblastoma SH-SY5Y cell line was used in this study.

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Background: Pulmonary thromboembolism (PTE), often arising from deep vein thrombosis, remains a high-mortality condition despite diagnostic advancements. Prognostic models like Pulmonary Embolism Severity Index (PESI) and sPESI identify low-risk groups effectively. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, reflecting nutritional status and systemic inflammation, shows prognostic value in cancers and cardiovascular diseases.

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  • The study aimed to compare various clinical and hormonal characteristics, treatment methods, and survival outcomes of ectopic Cushing's syndrome (ECS) between male and female patients.
  • Data was collected from 11 medical centers, evaluating 54 patients (28 females and 26 males), and found similarities in age, clinical presentation, and hormone levels despite some differences like higher rates of diabetes and osteoporosis in males.
  • Overall, the results showed comparable disease progression, treatment responses, and remission rates between sexes, but indicated that males experience more severe conditions such as hyperglycemia and osteoporosis.
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Objectives: A tracheostomy is a surgical procedure that can be performed on critically ill patients of all ages in intensive care units as indicated, and its use has been increasing in recent years. The most common indications are prolonged mechanical ventilation and upper airway obstruction. This study aimed to examine the indications for tracheostomy, assess the outcomes of patients who underwent the procedure, and identify the factors affecting these outcomes.

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  • * This study analyzed the effectiveness of two treatments, pazopanib and sunitinib, in non-ccRCC patients across 22 hospitals, looking at progression-free survival, overall survival, and patient response rates.
  • * The findings suggest that pazopanib and sunitinib have similar efficacy, with specific patient characteristics affecting outcomes; pazopanib could be considered a viable treatment option alongside sunitinib and cabozantinib.
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  • - The study assessed trauma CT interpretation proficiency among emergency medicine residents in Turkey, finding a median accuracy rate of 64.9% with factors influencing interpretation performance analyzed.
  • - Four main factors linked to interpretation failure were identified: shorter interpretation times, lower self-confidence, over-reliance on radiology reports, and lack of departmental training programs.
  • - The findings suggest the necessity for improved educational strategies in radiology for emergency medicine residents to enhance their skills in trauma CT interpretation and ultimately improve patient care outcomes.
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  • The study aimed to determine if patients who underwent percutaneous liver mass biopsy (PLMB) could be safely discharged after a two-hour monitoring period.
  • It involved 375 patients and found that minor complications occurred in 18.93% and major complications in 2.13%, mostly within the first two hours.
  • The conclusion indicated that the two-hour monitoring is sufficient for identifying most complications, suggesting that longer monitoring does not significantly enhance patient care.
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  • - The study investigates how effective the McMahon score is in predicting mortality due to rhabdomyolysis following earthquakes, linking it to life-threatening conditions arising from trapped individuals.
  • - It reviewed data from 151 patients who went to the emergency department after an earthquake, analyzing factors like creatine kinase and serum creatinine, and found that the McMahon score is significant in differentiating patients at risk of mortality.
  • - With a score cutoff of 6, the McMahon score showed an area under the curve of 0.723, with 80% sensitivity and 64.5% specificity, highlighting its importance in emergency medicine for quick decision-making.
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  • The study aimed to evaluate the prevalence of pancreatic steatosis (PS) using transabdominal ultrasonography in Turkish gastroenterology clinics and identify associated factors.
  • A total of 1,700 volunteers revealed a PS prevalence of 68.9%, with factors like age, BMI, and metabolic syndrome linked to its severity.
  • The study also found that 11.8% of PS cases were in lean individuals, who were generally younger and had lower metabolic risk factors compared to those with non-lean PS.
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Background:  Glutamatergic N-methyl-D-aspartate (NMDA) receptors play vital roles in memory formation. Changes in the activity of these receptors influence memory processes. Ketamine is a noncompetitive NMDA receptor antagonist drug with promising mood-altering and pain-reducing effects in low doses.

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Purpose: To evaluate the neuroprotective effect of resveratrol, urapidil, and a combined administration of these drugs against middle cerebral artery occlusion (MCAO) induced ischemia/reperfusion (IR) injury model in rats.

Methods: Thirty-five rats were divided into five groups of seven animals each. Animals in IR, IR resveratrol (IRr), IR urapidil (IRu), and IR + combination of resveratrol and urapidil (IRc) were exposed to MCAO induced cerebral ischemia reperfusion injury model.

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Background: Blood culture-negative endocarditis (BCNE) is a diagnostic challenge, therefore our objective was to pinpoint high-risk cohorts for BCNE.

Methods: The study included adult patients with definite endocarditis. Data were collected via the Infectious Diseases International Research Initiative (ID-IRI).

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