8,672 results match your criteria: "Diaphragmatic Hernias Congenital"

Validation and in silico function prediction of circtial1 as a novel marker of abnormal lung development in nitrofen-induced congenital diaphragmatic hernia (CDH).

Pediatr Surg Int

December 2024

Division of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, University of Manitoba, and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.

Purpose: Circular RNAs (circRNAs) are stable, non-coding RNAs with tissue- and developmental-specific expression making them suitable biomarkers for congenital anomalies. Current circRNA discovery pipelines have focused on human and mouse. We aim to bridge this gap by combining bioinformatics resources and used circtial1 as a model candidate in the nitrofen rat model of congenital diaphragmatic hernia (CDH).

View Article and Find Full Text PDF

Purpose: Congenital diaphragmatic hernia (CDH) is associated with congenital heart disease (CHD) and index newborns reportedly may experience cardiac arrhythmia disorders [Tella et al.-Pediatric Critical Care Medicine 2022]. This study analyses, details and reports contemporary outcome metrics of CHD and cardiac rhythm disease (CRD) in CDH babies attending a university surgical centre.

View Article and Find Full Text PDF

Aims: This study aimed to evaluate the Oxygen Saturation Index (OSI) as a noninvasive measure for early postnatal management and outcome prediction in neonates with congenital diaphragmatic hernia (CDH). Additionally, the study analyzed the correlation and predictive ability of OSI, Oxygenation Index (OI), Horovitz Index (HI), and partial pressure of arterial oxygen (PaO) regarding mortality and the need for extracorporeal membrane oxygenation (ECMO).

Methods: A retrospective, single-center study using data from 2013 to 2020.

View Article and Find Full Text PDF

Background: Extracorporeal membrane oxygenation (ECMO) is the only treatment option that can stabilize patients with congenital diaphragmatic hernia (CDH) with severe pulmonary hypertension. This study assessed the effects of a multidisciplinary ECMO team approach (META) as part of a quality improvement initiative aimed at enhancing the survival rates of neonates with CDH.

Methods: The medical records of infants with CDH treated at a tertiary center were retrospectively reviewed.

View Article and Find Full Text PDF

: This study aims to evaluate long-term physical and motor performance in children aged 3-6 years following congenital diaphragmatic hernia (CDH) surgery, in comparison with healthy peers. While existing research emphasizes prognostic factors such as the lung to heart ratio (LHR) and liver position, few studies address physical outcomes in early childhood post-surgery. : A total of 31 children who underwent neonatal CDH surgery (study group) and 41 age-matched healthy children (reference group) were assessed.

View Article and Find Full Text PDF

Genetic Diagnosis and Clinical Features of Fetuses With Congenital Diaphragmatic Hernia.

Prenat Diagn

December 2024

Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Objective: Congenital diaphragmatic hernia (CDH) is a rare abnormality with highly heterogeneous genetic causes. This study investigated chromosomal and monogenic abnormalities in fetal CDH patients and evaluated the efficacy of chromosomal microarray analysis (CMA) and whole-exome sequencing (WES) for genetic diagnosis. The clinical features of the patients were also evaluated.

View Article and Find Full Text PDF

Fetoscopic endoluminal tracheal occlusion (FETO) induces lung growth and may improve survival in congenital diaphragmatic hernia (CDH) but the effect on post-natal right (RV) and left (LV) ventricular size and cardiac function is unknown. Quantitative measures of heart size and function including tricuspid annular plane systolic excursion Z-score (TAPSEZ), RV fractional area change (RVFAC), RV global longitudinal and free wall strain (RVGLS, RVFWS), RV/LV ratio, LV eccentricity index (LVEI), and LV M-mode diastolic and systolic Z-scores (LVIDDZ, LVIDSZ) were compared between FETO and control patients on first post-natal echocardiogram, prior to and post CDH repair, and on last available echocardiogram using non-parametric Wilcoxon rank-sum test in a single-center, retrospective cohort study. Linear regression models evaluated change over time, adjusting for clustering and interaction of echocardiogram parameters with time.

View Article and Find Full Text PDF

Objectives: This study aims to describe the indications, complications, yield, and safety of amniocentesis beyond 24 weeks for prenatal diagnostic procedures along with the associated maternal and fetal outcomes.

Methods: A retrospective analysis was conducted on 60 pregnant women (with 61 fetuses) who underwent amniocentesis at or beyond 24 weeks from March 2021 to June 2023 at a tertiary care referral center. Data was collected from medical records and individual patient followups.

View Article and Find Full Text PDF

Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of the diaphragm. While the ensuing compression to the fetal lung causes lung hypoplasia, specific cellular phenotypes and developmental signaling defects in the alveolar epithelium in CDH are not fully understood. Employing lung samples from human CDH, a surgical lamb model and a nitrogen rat model, we investigate whether lung compression impairs alveolar epithelial differentiation and Yes-associated protein (YAP)-mediated mechanosensing.

View Article and Find Full Text PDF

Background And Aims: Morgagni hernias are rare congenital diaphragmatic defects that can lead to bowel obstruction and incarceration if not repaired. While this disease typically manifests as respiratory distress, frequent respiratory infections, and infant growth failure, it can sometimes be accidentally discovered in adulthood through cross-sectional imaging. We aimed to report our experience managing this entity during 20 years at our referral center.

View Article and Find Full Text PDF
Article Synopsis
  • Spondylocostal dysostosis (SCD) is a genetic disorder leading to vertebrae and rib abnormalities, resulting in complications like kyphoscoliosis and lung issues.* -
  • A case study discusses a pregnant woman with severe kyphoscoliosis and lung problems who safely underwent cesarean delivery using modified anesthesia techniques.* -
  • The report highlights the importance of tailored anesthetic strategies for patients with SCD to ensure safety during surgical procedures.*
View Article and Find Full Text PDF

Background: Antenatal fetoscopic endoluminal tracheal occlusion (FETO) has been introduced as an effective intervention to improve the outcome of severe congenital diaphragmatic hernia (CDH).

Objective: We report our early experience with FETO.

Design: A retrospective chart review of case series.

View Article and Find Full Text PDF
Article Synopsis
  • A unique case study describes a preschooler with a right-sided BH and patent ductus arteriosus (PDA), requiring two different surgical approaches for treatment.
  • This case is the first documented instance of a pediatric right-sided BH involving the appendix alongside congenital heart disease, leading to the proposal of the term Bhende-Pathak hernia for this variant.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess the neurodevelopment of infants with congenital gastrointestinal malformations at 2 years old and explore links between developmental delay and health history.
  • It analyzed 118 infants who underwent surgery for various gastrointestinal issues, finding that 9% experienced developmental delay according to the Ages and Stages Questionnaire.
  • Factors like earlier gestational age, extended invasive ventilation, and multiple hospitalizations were associated with developmental delays, while breastfeeding appeared to have a protective effect.
View Article and Find Full Text PDF

Perforated gastric volvulus in a child with undiagnosed congenital diaphragmatic hernia (case report).

Int J Surg Case Rep

December 2024

University Tunis El Manar Medical school, Tunisia; Department of pediatric surgery A, Children's Hospital Bechir Hamza, Tunisia.

Article Synopsis
View Article and Find Full Text PDF

Yes-associated protein is dysregulated in human congenital diaphragmatic hernia patients during mid and end gestation.

Pediatr Surg Int

December 2024

Division of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.

Article Synopsis
View Article and Find Full Text PDF

Introduction: Neonates with congenital diaphragmatic hernia (CDH) who undergo repair while on extracorporeal membrane oxygenation (ECMO) are at risk of developing post-operative bleeding complications. Balanced anticoagulation is critical to maintain ECMO flow and avoid bleeding. Heparin has historically been our first-line anticoagulant; however, recently, we transitioned to bivalirudin, a direct thrombin inhibitor.

View Article and Find Full Text PDF

Neonatal Airway Management and Outcomes Following Fetoscopic Endoluminal Tracheal Occlusion (FETO): A Single-Center Descriptive Analysis.

J Surg Res

December 2024

Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital and Baylor, College of Medicine, Houston, Texas; Texas Children's Fetal Center, Baylor College of Medicine, Houston, Texas. Electronic address:

Article Synopsis
  • Congenital diaphragmatic hernia is a serious condition that can lead to issues like underdeveloped lungs and high blood pressure, but a procedure called fetoscopic endoluminal tracheal occlusion (FETO) has shown to improve patient survival despite some complications like tracheomegaly (enlarged trachea).
  • A study analyzed 34 patients who underwent FETO, finding that tracheomegaly was present in 24 of them, with most needing intubation right after birth, some requiring a transition to cuffed endotracheal tubes (ETTs) due to concerns like air leaks.
  • The findings suggest that larger or cuffed ETTs may be more beneficial for
View Article and Find Full Text PDF
Article Synopsis
  • - In recent years, multipotent mesenchymal stromal cells (MSCs) have emerged as a potential therapy for lung regeneration in preterm infants, suggesting their use could also benefit conditions like pulmonary hypoplasia seen in congenital diaphragmatic hernia.
  • - A case study highlighted a newborn with a left congenital diaphragmatic hernia who received two MSC treatments, resulting in improved respiratory function and nutrition without any side effects.
  • - While MSC therapy shows promise for addressing pulmonary hypoplasia and intestinal issues related to congenital diaphragmatic hernia, further research is needed to understand side effects, optimal dosages, and administration techniques.
View Article and Find Full Text PDF

Amniotic fluid stem cell extracellular vesicles promote lung development via TGF-beta modulation in a fetal rat model of oligohydramnios.

J Control Release

January 2025

Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada; Department of Surgery, University of Toronto, Toronto M5T 1P5, Canada. Electronic address:

Oligohydramnios (decreased amniotic fluid volume for gestational age) is a severe condition associated with high morbidity and mortality mainly due to fetal pulmonary hypoplasia. Currently, there are limited treatment options to promote fetal lung development. Administration of stem cells and their derivates have shown promising regenerative properties for several fetal and neonatal diseases related to arrested lung development.

View Article and Find Full Text PDF