6,588 results match your criteria: "Diabetic Foot Infections"
Bioorg Chem
December 2024
College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, 93 East Jichuan Road, Hailing District, Taizhou, Jiangsu 225300, China. Electronic address:
Single treatment methods for wound infections caused by drug-resistant bacteria often fail to simultaneously achieve high antimicrobial efficacy and wound healing efficiency. Therefore, it is crucial to develop a small molecule prodrug that can achieve both goals, in this context, we have engineered a green-light-activated nitric oxide photocage/photodynamic therapeutic prodrug, designed to release NO, which not only potentiates antimicrobial efficacy but also facilitates collagen accumulation at the wound interface, thereby expediting the wound healing process. Additionally, it mitigates tissue inflammation by suppressing the NF-κB signaling pathway.
View Article and Find Full Text PDFCureus
November 2024
General Surgery/Breast and Endocrine Surgery, Al Kharj Armed Forces Hospital, Riyadh, SAU.
Background: Vascular complications from diabetes contribute significantly to major and minor limb amputations. Diabetes is a major health burden in Saudi Arabia, with increased incidence in rural areas. The purpose of this study was to evaluate the timing of minor lower limb amputations after revascularization and their relative outcomes.
View Article and Find Full Text PDFCardiovasc Diabetol
December 2024
Medical School, The University of Western Australia, Perth, Australia.
Diabetes-related foot ulceration (DFU), a serious but preventable complication of diabetes, is a leading cause of hospitalisation, lower extremity amputation and disability worldwide. People with DFU have a greater burden of cardiovascular risk factors, heart failure and chronic kidney disease, resulting in over two-fold higher risk of cardiovascular death compared with people with diabetes without DFU. Here, we propose a "cardio-renal-metabolic-foot" connection in people with diabetes based on shared pathophysiological mechanisms linking DFU with cardiovascular and renal disease.
View Article and Find Full Text PDFAim: Diabetic Charcot neuro-osteoarthropathy carries a significant worldwide disease burden including diabetic foot infection, ulceration and amputation. The current accepted standard of treatment during the active phase of Charcot neuro-osteoarthropathy is offloading with total contact casting; however, controversy remains regarding weight-bearing status during this period.
Methods: A systematic review was performed following PRISMA guidelines of Pubmed, EMBASE, MEDLINE and the Cochrane central register of controlled trials for clinical studies from inception until June 2024 investigating weight-bearing and non-weight-bearing total contact casting for active Charcot neuro-osteoarthropathy.
World J Microbiol Biotechnol
December 2024
Department of Pathology, College of Medicine, University of Hail, Hail, Saudi Arabia.
This study aims to evaluate the antibiotic susceptibility profiles of bacterial isolates from DFU patients, identify the prevalence of MDROs, and identify specific risk factors contributing to these infections to inform effective antibiotic treatment strategies. This prospective cohort study included 187 DFU patients from March 2023 to February 2024 at King Khalid Hospital, Saudi Arabia. The exclusion criteria were nondiabetic ulcers, specific infections, tumours, or recent antibiotic use.
View Article and Find Full Text PDFDermatologie (Heidelb)
December 2024
Colentina Klinik, Dermatologie 2, "Carol Davila" Universität für Medizin und Pharmazie, Bukarest, Rumänien.
Treatment of diabetic foot is challenging due to the complex pathophysiological mechanisms, various clinical manifestations, severe complications with considerable impairment of quality of life, and the need for special, individualized treatment strategies. Particularly in the case of diabetic foot ulcers, conventional therapies are not always effective, so new treatment strategies are needed. This review aims to present alternative therapies with current efficacy data for diabetic foot ulcers that may be suitable for treatment-refractory ulcers.
View Article and Find Full Text PDFDiabetes Metab Syndr
December 2024
Department Nursing and Podiatry. Faculty of Health Sciences. University of Málaga, Malaga, Spain. Electronic address:
Introduction: This study explored the effectiveness of current placenta-derived biomaterials therapies in ulcer healing in DFU compared to standard of care (SOC).
Methods: The systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. The electronic databases of PubMed, EMBASE, and Web of Science (WoS) internet were searched for the outcome rate of complete ulcer healing.
Adv Healthc Mater
December 2024
Department of Orthopedics, Second Affiliated Hospital, Air Force Medical University, 1 Xinsi Rd, Xi'an, Shaanxi, 710038, China.
A diabetic foot ulcer (DFU) is a common and serious complication of diabetes. This complication can result in amputation and death because of the several challenges associated with wound healing that can be attributed to the complex wound microenvironment, including biofilm infection, hyperglycemia, and diabetic angiopathy. Existing investigations on the wound-healing rate consider only one or two pathogenic factors, and therefore, despite the extensive research on these pathological microenvironments, there is an urgent need to optimize the wound-healing rate in patients with diabetic foot ulcers.
View Article and Find Full Text PDFClin Diabetes Endocrinol
December 2024
University of Manchester, Manchester, UK.
Background: The management of diabetic foot osteomyelitis (DFO) is complex. The targeted use of adjuvant local antibiotics, in the form of biocomposite bone void filler, in DFO, can enhance patient outcomes while minimising the adverse effects associated with systemic antibiotic therapy and its shortcomings.
Methods: We reviewed a series of 105 consecutive patients who underwent surgical management for diabetic foot osteomyelitis.
Int Wound J
December 2024
Unit 7, Pioneer, Wound Healing and Lymphoedema Centres, Sussex, UK.
The objective of the study was to show the clinical performance and cost-effectiveness of a Silicone foam dressing with 3DFit™ Technology compared to current standard of care. This was an open-labelled, two-arm, randomised controlled multicentre study conducted from February to December 2023. One hundred and two participants with an exuding, non-infected and chronic ulcer were randomised in a 1:1 fashion and treated with either a Silicone foam with 3DFit™ Technology or standard of care (a filler combined with a secondary dressing), stratified by venous leg ulcers and diabetic foot ulcers.
View Article and Find Full Text PDFIndian J Microbiol
December 2024
Department of Community Medicine, Integral Institute of Medical Sciences and Research, Kursi Road, Lucknow, Uttar Pradesh 226026 India.
One of the most prominent challenges related to the management of diabetes is a diabetic foot ulcer (DFU). It has been noted that > 50% of ulcers become clinically infected in diabetic patients, and up to 15-25% of diabetic patients may acquire DFU in their lifetime. DFU treatment is complicated for immune-compromised individuals and has a low success rate.
View Article and Find Full Text PDFWorld J Diabetes
December 2024
Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil Essonne 91100, France.
Background: Diabetic foot ulcers (DFUs) are a real public health problem which carry a high risk of amputation. The treatment of DFUs is based on general management such as the treatment of infection, arterial disease, and offloading, but recent studies have shown that the quality of the local covering can impact the healing rate.
Case Summary: We report the case of a 39-year-old man, living with diabetes since the age of 15, who developed DFU on the dorsum of his left foot, with muscle and tendon involvement.
World J Diabetes
December 2024
Department of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
In this paper, we provide a commentary on an article focusing on diabetic foot ulcer (DFU) as a dreadful complication of diabetes mellitus. The development of this condition is influenced by factors such as diabetic peripheral neuropathy, lower extremity artery disease, and infection. However, the underlying mechanism remains elusive.
View Article and Find Full Text PDFWound Repair Regen
December 2024
Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Our objective was to assess the incidence, risk factors and clinical outcomes of dehiscence after foot surgery in diabetic patients. We used pooled patient-level data from two randomised clinical trials with 240 diabetic patients who required foot surgery for infections. Most patients (n = 180, 75.
View Article and Find Full Text PDFInt Wound J
December 2024
Biofunctional Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
A wide variety of microbial species, including Trichophyton spp., have been detected in diabetic foot ulcers (DFUs). In particular, Trichophyton spp.
View Article and Find Full Text PDFAm J Case Rep
December 2024
Wound Care Research, SerenaGroup® Research Foundation, Cambridge, MA, USA.
BACKGROUND Diabetes mellitus is a significant global health issue, affecting millions and costing billions annually in management. A major complication of diabetes is foot ulcers, which heal slowly due to nerve damage (neuropathy) and poor circulation. These ulcers have a high risk of infection and, if untreated, can lead to amputation.
View Article and Find Full Text PDFZhonghua Yi Xue Za Zhi
December 2024
Department of Endocrinology, the Ninth Medical center 0f Chinese PLA General Hospital, Beijing100101, China.
Zhonghua Yi Xue Za Zhi
December 2024
Department of Endocrinology, Air Force Medical Center, Beijing100142, China.
Zhonghua Yi Xue Za Zhi
December 2024
Department of Endocrinology, Central Hospital Affiliated to Chongqing University, Chongqing Diabetic Podiatry Research Center, Chongqing400014, China.
Diabetic foot is a highly complex and severe complication of diabetes, posing significant challenges in treatment and imposing substantial medical costs. Wound healing stands as the primary concern for both healthcare professionals and patients in the management of diabetic foot. Individuals with severe diabetic foot often suffer from multiple organ failure and acute lesions.
View Article and Find Full Text PDFOxf Med Case Reports
December 2024
Haematology, Colchester Hospital, East Suffolk and North Essex NHS Foundation Trust, Turner Road, Colchester, United Kingdom.
Aesthetic Plast Surg
December 2024
Department of Facial Plastic & Cranio-Maxillo-Facial Surgery, Fakih Hospital, Khaizaran, Lebanon.
Introduction: Chronic wounds present a significant challenge in clinical practice due to complications like infections and prolonged healing times. Conventional treatments often fall short, necessitating advancements in wound healing strategies. This article introduces a novel approach using a combination of adipose-derived stem cells (ADSCs) from fat and growth factors from platelet-rich fibrin (PRF) to enhance wound healing outcomes.
View Article and Find Full Text PDFWound Repair Regen
December 2024
Department of Plastic Surgery, University of Texas Southwestern, Dallas, Texas, USA.
This meta-analysis aimed to systematically assess and synthesise healing rates within a 12- to 24-week treatment period among patients with diabetic foot ulcers receiving standard-of-care interventions in randomised controlled trials. This meta-analysis included 32 randomised controlled trials conducted between 1996 and 2023, with sample sizes ranging from 9 to 169 patients. A random-effects model was applied to estimate pooled healing and infection rates.
View Article and Find Full Text PDFIran Biomed J
December 2024
Department of Clinical Pharmacy, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
Int J Nanomedicine
December 2024
College of Medicine, Sharjah University, Sharjah, United Arab Emirates.
Background: Diabetic foot ulcers present a formidable challenge due to colonization by biofilm-forming microorganisms, heightened oxidative stress, and continuous wound maceration caused by excessive exudation.
Methods: To address these issues, we developed a robust, stretchable, electro-conductive, self-healing, antioxidant, and antibiofilm hydrogel. This hydrogel was synthesized through the crosslinking of polyvinyl alcohol (PVA) and chitosan (CH) with boric acid.