The effect of various ultrasonic and hand instruments on the root surfaces of human single rooted teeth: A Planimetric and Profilometric study.

Background: The purpose of this study was to compare the effectiveness of different ultrasonic scalers and a periodontal curette on the root surfaces for calculus removal and root surface roughness.

Materials And Methods: 40 single rooted teeth with subgingival calculus destined for extraction were assigned to one of three experimental groups (n = 10, in each group) and one control group (untreated, n = 10). Experimental groups were: Group 1: Piezoelectric ultrasonic group; Group 2: Magnetostrictive ultrasonic group; Group 3: Hand instrumentation group (Curette).

Molecular Modeling Studies of Thiophenyl C-Aryl Glucoside SGLT2 Inhibitors as Potential Antidiabetic Agents.

A QSAR study on thiophenyl derivatives as SGLT2 inhibitors as potential antidiabetic agents was performed with thirty-three compounds. Comparison of the obtained results indicated the superiority of the genetic algorithm over the simulated annealing and stepwise forward-backward variable method for feature selection. The best 2D QSAR model showed satisfactory statistical parameters for the data set (r (2) = 0.

Assessment of phytotoxicity of anthracene in soybean (Glycine max) with a quick method of chlorophyll fluorescence.

A decrease in photosynthetic efficiency may indicate the toxic effects of environmental pollutants on higher plants. Measurement of chlorophyll (Chl) a fluorescence to assess the performance of photosystem II (PSII) was used as an bioindicator of toxicity of the polycyclic aromatic hydrocarbon (PAH) anthracene (ANT) in soybean plants. The results revealed that ANT treatment caused a reduction in quantum yield of PSII, damage to the oxygen evolving complex, as well as a significant reduction in performance index of PSII.

Antiatherosclerotic and Cardioprotective Potential of Acacia senegal Seeds in Diet-Induced Atherosclerosis in Rabbits.

Acacia senegal L. (Fabaceae) seeds are essential ingredient of "Pachkutta," a specific Rajasthani traditional food. The present study explored antiatherosclerotic and cardioprotective potential of Acacia senegal seed extract, if any, in hypercholesterolemic diet-induced atherosclerosis in rabbits.

Pyrroloquinoline quinone ameliorates oxidative stress and lipid peroxidation in the brain of streptozotocin-induced diabetic mice.

Diabetes, characterized by hyperglycemia, leads to several complications through the generation of reactive oxygen species and initiates tissue damage. Pyrroloquinoline quinone (PQQ) is believed to be a strong antioxidant, as it protects cells from oxidative damage. In this study, we elucidated the hitherto unknown potential of PQQ to ameliorate the brain damage caused by diabetes mellitus and the associated hyperglycemia-induced oxidative damage.

Synthetic, spectral, thermal and powder X-ray diffraction studies of bis(O-alkyldithiocarbonato-S,S') antimony(III) dialkyldithiocarbamates.

Compounds of antimony(III) with mixed sulfur donor ligands of the type [(ROCS2)2SbS2CNR'2] (where, R=C2H5, and (i)C3H7; R'=CH3, C2H5, and CH2CH2) have been synthesized using anhydrous acetone as a solvent by the one pot reaction of antimony(III) tris(O-alkyldithiocarbonato-S,S'), antimony(III) chloride and sodium/ammonium salt of dialkyldithiocarbamate in 2:1:3molar ratios. These compounds have been characterized by physicochemical [melting points, molecular weight determinations, elemental analyses (C, H, N, S, and Sb)], spectral [UV, IR, Far-IR and NMR ((1)H and (13)C)] studies. In IR spectra strong band was observed at 1028-1051cm(-1) which indicates anisobidentate mode of bonding of both the ligands with antimony metal.

Antithyroid effects of naringin, hesperidin and rutin in l-T4 induced hyperthyroid rats: possible mediation through 5'DI activity.

Background: Investigations are meager on the ameliorative role of plant based active compounds in regulating hyperthyroidism. We have now explored the possible role of three flavonoids in the regulation of L-thyroxine (l-T4)-induced hyperthyroidism in rats. This investigation attempts to reveal whether rutin, naringin and hesperidin supplementation exhibit antithyroid effects in L-T4-induced hyperthyroid rats and to work out the possible involvement of free radicals in their mode of action.

A quick method to screen high and low yielding wheat cultivars exposed to high temperature.

In tropical countries, high temperature stress is the major abiotic stress, which controls the productivity and yield of crop plants. Two high yielding and low yielding genotypes of durum wheat were selected for detailed analysis of their photochemical efficiencies. In low yielding genotypes (Malvi local and Sawer local), the whole primary photochemical reactions are affected before and after heat stress.

Alterations in photochemical efficiency of photosystem II in wheat plant on hot summer day.

In this study the effect of increasing temperature on photochemical efficiency of PS II in wheat plants has been studied on a hot summer day (9:00 AM (Control)-7:00 PM) by measuring Chl a fluorescence. Increasing temperature for a short period of time (2-4 h), in nature affects the efficiency of PS II complex reversibly and does not cause permanent damage to any of the components of photosystem II. A scheme has been provided to demonstrate the sequence and severity of events which get affected maximum by temperature stress.

Molecular modelling studies for the discovery of new substituted pyridines derivatives with angiotensin II AT1 receptor antagonists.

A QSAR study has been performed on a series of pyridines derivatives with potent angiotensin II AT1 receptor antagonists. Structural features responsible for the activity of the compounds were characterized by using topological, electrotopological, group based and 3D descriptors, calculated from the Molecular Design Suite software (V-life MDS 3.5).

Expression, purification, crystallization and preliminary X-ray diffraction analysis of acylpeptide hydrolase from Deinococcus radiodurans.

Acylpeptide hydrolase (APH; EC 3.4.19.

Identification of 3-nitro-2, 4, 6-trihydroxybenzamide derivatives as photosynthetic electron transport inhibitors by QSAR and pharmacophore studies.

In the present investigation, QSAR analysis was performed on a data set consist of structurally diverse compounds in order to investigate the role of its structural features on their Photosynthetic Electron Transport Inhibitors. The herbicidal activity co-related with certain topological and hydrophobicity based descriptors, 3D descriptors dependent steric, electrostatic and hydrophobic. The best 2D QSAR model was selected, having correlation coefficient r = 0.

Structural requirements of some 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide derivatives as poly (ADP-ribose) polymerase (PARP) for the treatment of cancer: QSAR approach.

The present study is aimed to elucidate the structural features of substituted 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide required for poly (ADP-ribose) polymerase inhibition and to obtain predictive 2D QSAR models to guide the rational synthesis of novel poly (ADP-ribose) polymerase inhibitors. The statistical analysis has shown that excellent results are obtained by using partial least regression based on simulated annealing method. The best model was selected based on the highest correlation coefficient r = 0.

A structure-activity relationship study of imidazole-5-carboxylic acids derivatives as angiotensin II receptor antagonists combining 2D and 3D QSAR methods.

Two Dimensional (2D) and Three Dimensional (3D) Quantitative Structure-Activity Relationship (QSAR) studies were performed for correlating the chemical composition of Imidazole-5-carboxylic Acids analogues and their Angiotensin II AT Receptor Antagonists activity using partial least squares and k Nearest Neighbor respectively. For Comparing the three different feature selection methods of 2D-QSAR, k Nearest Neighbor models was used in conjunction with simulated annealing (SA), genetic algorithm (GA) and stepwise (SW) coupled with Partial least square (PLS) showed variation in biological activity. The statistically significant best 2D-QSAR model having good predictive ability with statistical values of r = 0.

Discovery of potent antihypertensive ligands substituted imidazolyl biphenyl sulfonylureas analogs as angiotensin II AT receptor antagonists by molecular modelling studies.

To elucidate the structural properties required for antihypertensive activity, three different molecular modeling techniques; two-dimensional Quantitative structure activity relationship (2D-QSAR), Group-Based Quantitative structure activity relationship (G-QSAR), and three-dimensional Quantitative structure activity relationship (3D-QSAR) studies have been carried out on a series of substituted imidazolyl biphenyl sulfonylureas derivatives. Multiple linear regressions methodology, viz. variable simulated annealing (SA) and stepwise (SW) methods, was applied to derive models which were further validated for statistical significance and predictive ability by internal and external validation.

Comparative pharmacophore modeling and QSAR studies for structural requirements of some substituted 2-aminopyridines derivatives as inhibitors nitric oxide synthases.

The present studies are an attempt in this direction seeking for the development and comparison of QSAR models of substituted 2-aminopyridines derivatives as inhibitors of nitric oxide synthases by different feature selection methods. Comparing the two different feature selection methods, it is implicit that the model built with the selected variables by simulated annealing (SA) method gives better prediction in case of 2D and 3D QSAR modeling. The QSAR study was carried out on V-life Molecular Design Suite software and the derived best QSAR model was derived by partial component regression (PCR) method.

Foliar application of pyraclostrobin fungicide enhances the growth, rhizobial-nodule formation and nitrogenase activity in soybean (var. JS-335).

A field study was conducted to investigate the impact of the fungicide pyraclostrobin (F500 - Headline®; a.i. 20%) on the activity of nitrogenase in soybean (var.

Fluoranthene, a polycyclic aromatic hydrocarbon, inhibits light as well as dark reactions of photosynthesis in wheat (Triticum aestivum).

The toxic effect of fluoranthene (FLT) on seed germination, growth of seedling and photosynthesis processes of wheat (Triticum aestivum) was investigated. Wheat seeds were exposed to 5 µM and 25 µM FLT concentrations for 25 days and it was observed that FLT had inhibiting effect on rate of seed germination. The germination rate of wheat seeds decreased by 11% at 25 µM FLT concentration.

Cyclic electron flow around photosystem I is enhanced at low pH.

Earlier studies have shown that at low pH (pH 5.5), PS II fluorescence decreases with concomitant increase in PS I fluorescence (Singh-Rawal et al., 2010).

A comparative protein profile of mammalian erythrocyte membranes identified by mass spectrometry.

A comparative analysis of erythrocyte membrane proteins of economically important animals, goat (Capra aegagrus hircus), buffalo (Bubalus bubalis), pig (Sus scrofa), cow (Bos tauras), and human (Homo sapiens) was performed. Solubilized erythrocyte membrane proteins were separated by sodium dodecyl sulfate-polyacryamide gel electrophoresis (SDS-PAGE), visualized by staining the gels with Commassie Brilliant Blue (CBB), and identified by matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS). Emerging results show that all major erythrocyte membrane proteins present in human are also seen in all the animals except for band 4.

Pyrroloquinoline quinone ameliorates l-thyroxine-induced hyperthyroidism and associated problems in rats.

Pyrroloquinoline quinone (PQQ) is believed to be a strong antioxidant. In this study, we have evaluated its hitherto unknown role in l-thyroxin (L-T4 )-induced hyperthyroidism considering laboratory rat as a model. Alterations in the serum concentration of thyroxin (T4 ) and triiodothyronine (T3 ); lipid peroxidation (LPO) of liver, kidney, heart, muscles and brain; in the endogenous antioxidants such as superoxide dismutase, catalase and glutathione and in serum total cholesterol, high-density lipoprotien, triglycerides, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT) and urea were evaluated.

Effects of density functionals and dispersion interactions on geometries, bond energies and harmonic frequencies of EUX3 (E=N, P, CH; X=H, F, Cl).

Quantum-chemical calculations have been performed to evaluate the geometries, bonding nature and harmonic frequencies of the compounds [EUX3] at DFT, DFT-D3, DFT-D3(BJ) and DFT-dDSc levels using different density functionals BP86, BLYP, PBE, revPBE, PW91, TPSS and M06-L. The stretching frequency of UN bond in [NUF3] calculated with DFT/BLYP closely resembles with the experimental value. The performance of different density functionals for accurate UN vibrational frequencies follows the order BLYP>revPBE>BP86>PW91>TPSS>PBE>M06-L.

A review on management of chrome-tanned leather shavings: a holistic paradigm to combat the environmental issues.

Raw hide/skins come to the tanners as a by-product of meat industry which is converted into value-added leather as product for fashion market. Leather manufacturing is a chemical process of natural biological matrix. It employs a huge quantity of water and inorganic and organic chemicals for processing and thereby discharges solid and liquid wastes into the environment.

Towards further understanding on the antioxidative activities of Prunus persica fruit: a comparative study with four different fractions.

In the present study we have evaluated the antioxidant activities of different fractions (hexane, ethyl acetate, n-butanol and aqueous fractions) of Prunus persica fruit. For extraction simple warring blender method was employed and total phenolic and flavonoid contents were correlated with different antioxidant activities (total antioxidant, 2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2 scavenging, superoxide radical scavenging, iron chelating and their reducing power properties). Different in vitro antioxidant studies showed that ethyl acetate and n-butanol fractions had the maximum activities that were well correlated with total phenolic and flavonoid contents.