191 results match your criteria: "Development and Engineering Center[Affiliation]"

Schisandra sphenanthera extract modulates sweet taste receptor pathway, IRS/PI3K, AMPK/mTOR pathway and endogenous metabolites against T2DM.

Phytomedicine

December 2024

School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China; College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xi'an 712046, PR China; Shaanxi Key Laboratory of Research and Application of"Taibai Qi Yao", Xianyang 712046, PR China. Electronic address:

Article Synopsis
  • Schisandra sphenanthera, a fruit used in traditional medicine, is reported to have beneficial effects on diabetes mellitus (DM) by helping with symptoms like prolonged cough and thirst and may aid in diabetes prevention and control.
  • The research aims to uncover how Schisandra Sphenanthera (SDP) works against type 2 diabetes mellitus (T2DM) through various scientific methods like biochemical analysis and metabolite assays.
  • Findings reveal that SDP can lower blood glucose levels, improve metabolic functions, and activate specific signaling pathways, ultimately leading to therapeutic effects on T2DM and restoring damage in organs like the liver and pancreas.
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The chloroplast genome sequence and phylogenetic analysis of Rubia alata Wall and Rubia ovatifolia Z. Ying Zhang. (Rubiaceae).

Mol Biol Rep

November 2024

Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China.

Background: Rubia alata Wall (R. alata) and Rubia ovatifolia Z. Ying Zhang (R.

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The complete plastid genome of P. Y. Li (Asparagaceae): characterization and phylogeny.

Mitochondrial DNA B Resour

October 2024

College of Pharmacy, Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xi'an, China.

P. Y. Li is a perennial rhizomatous medicinal herb endemic to China with recognized medicinal value.

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Comparative transcriptome analysis and identification of candidate bZIP transcription factors involved in anthraquinone biosynthesis in Rheum officinale Baill.

Genomics

November 2024

Key Laboratory for Research and Development of "Qin Medicine" of Shaanxi Administration of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xi'an 712046, China; College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xi'an 712046, China; State Key Laboratory of Research and Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xianyang 712083, China. Electronic address:

Rhubarb is a traditional medicinal plant in China, whose pharmacological effects derive mainly from its anthraquinones. However, the regulatory mechanism affecting anthraquinone biosynthesis in R. officinale remains poorly understood.

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Article Synopsis
  • The study investigates the anti-inflammatory properties of two color variants of Farfarae Flos (yellowish-white and purplish-red) to determine any differences in their effectiveness against inflammation-related diseases.
  • Utilizing an inflammation model and mouse studies, the research assesses the inhibitory effects of these flower types on several inflammatory factors, including IL-6 and nitric oxide.
  • Non-targeted metabolomics is applied to identify and compare metabolites in the two variants, leading to the discovery of 48 compounds linked to significant anti-inflammatory activity.
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Therapeutic mechanism of Cornus Officinalis Fruit Coreon on ALI by AKT/Nrf2 pathway and gut microbiota.

Phytomedicine

July 2024

College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China; Shaanxi Key Lab. of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi University of Chinese Medicine, Xianyang 712046, China; College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, China; Shaanxi Provincial Administration of Traditional Chinese Medicine Key Laboratory of Mechanical and Material Basis of Chinese Medicine, Xianyang 712046, China; Key Research Laboratory of the Administration of Traditional Chinese Medicine of Shaanxi Province: Research and Application of Tai Bai Seven Medicines, Xianyang 712046, China. Electronic address:

Background: Acute liver injury (ALI) often precipitates severe liver function impairment and is associated with high mortality rates. Traditional Chinese Medicine (TCM) has demonstrated efficacy in mitigating hepatic damage by exhibiting anti-inflammatory effects, enhancing antioxidant activity, and modulating gut microbiota (GM). Numerous studies have identified similar or identical bioactive compounds within the Cornus Officinalis Fruit Coreon(COFO) and its flesh.

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Petroleum ether extract of Schisandra sphenanthera prevents hyperglycemia and insulin resistance in association with modulation of sweet taste receptors and gut microbiota in T2DM rats.

J Ethnopharmacol

September 2024

College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China; Shaanxi Key Lab. of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi University of Chinese Medicine, Xianyang, 712046, China; College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xianyang, 712046, China; Shaanxi Provincial Administration of Traditional Chinese Medicine Key Laboratory of Mechanical and Material Basis of Chinese Medicine, Xianyang, 712046, China; Key Research Laboratory of the Administration of Traditional Chinese Medicine of Shaanxi Province: Research and Application of Tai Bai Seven Medicines, Xianyang, 712046, China. Electronic address:

Ethnopharmacological Relevance: Schisandra sphenanthera (Schisandra sphenanthera Rehd. et Wils.) is the dried mature fruit of Schisandra sphenanthera, a plant in the Magnoliaceae family.

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Comprehensive evaluation of chemical constituents and antioxidant activity between crude and processed Polygalae radix based on UPLC-Q-TOF-MS/MS combined with multivariate statistical analysis.

Heliyon

March 2024

Key Laboratory for Research of "Qin Medicine" of Shaanxi Administration of Traditional Chinese Medicine, Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, 712046, Shaanxi, China.

Polygalae radix (PR) is a famous herbal medicine obtained by drying the root of Willd., one of the traditional Chinese medicines (TCM) that can be used for healthy food. There are three main processed methods of PR, including removing the xylem of roots (Polygalae Cortex, PC), frying PC with licorice (LP), and frying PC with honey (HP).

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Comparative transcriptome analysis and identification of candidate R2R3-MYB genes involved in anthraquinone biosynthesis in Rheum palmatum L.

Chin Med

February 2024

Key Laboratory for Research and Development of "Qin Medicine" of Shaanxi Administration of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, 712046, China.

Background: Rheum palmatum L. has important medicinal value because it contains biologically active anthraquinones. However, the key genes and TFs involved in anthraquinone biosynthesis and regulation in R.

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Objective: The classification and clinical usage of the different species of bead ginseng are often confused. Therefore, we conducted an integrated metabolomics and transcriptome analysis of three main species of Panax, including , , and var. .

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Analysis of codon usage patterns in chloroplast genome.

Chin Herb Med

April 2023

College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xi' an 712046, China.

Objective: In order to distinguish the traditional Chinese medicine and its adulterants effectively and develop a better understanding of the factors affecting synonymous codon usage, codon usage patterns of chloroplast genome, we determine the complete chloroplast (cp) genome of and clarify the main factors that influence codon usage patterns of 78 genes in chloroplast genome.

Methods: The total genomic DNA of fresh leaves from a single individual of was extracted with EASYspin plus Total DNA Isolation Kit and 2 μg genome DNA was sequenced using Illumina Hiseq 2500 Sequencing Platform. The cp genome of was reconstructed with MITObim v1.

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Problem formulation (PF) is a critical initial step in planning risk assessments for chemical exposures to wildlife, used either explicitly or implicitly in various jurisdictions to include registration of new pesticides, evaluation of new and existing chemicals released to the environment, and characterization of impact when chemical releases have occurred. Despite improvements in our understanding of the environment, ecology, and biological sciences, few risk assessments have used this information to enhance their value and predictive capabilities. In addition to advances in organism-level mechanisms and methods, there have been substantive developments that focus on population- and systems-level processes.

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Baicalin and berberine hydrochloride are the main chemical compositions of and respectively. and are two traditional Chinese herbs that are commonly used together in compounded formulations to treat colitis. Therefore, the combination of Baicalin and berberine hydrochloride (BBH) to treat colitis was studied.

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Background: Load carriage is common in a wide range of professions, but prolonged load carriage is associated with increased fatigue and overuse injuries. Exoskeletons could improve the quality of life of these professionals by reducing metabolic cost to combat fatigue and reducing muscle activity to prevent injuries. Current exoskeletons have reduced the metabolic cost of loaded walking by up to 22% relative to walking in the device with no assistance when assisting one or two joints.

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[Utilization strategies of Chinese medicinal solid waste by pyrolysis and gasification technology].

Zhongguo Zhong Yao Za Zhi

October 2021

Shaanxi Qin ling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine Xianyang 712046, China.

With the advantages of extensive sources, easy collection, renewability, high yield, carbon circulation, low pollution, and so on, Chinese medicinal solid waste can be converted into clean gas by pyrolysis and gasification, which is then able to serve for industrial production. This is of great practical significance in the context of energy shortage and for solid waste recycling in China. This paper reviews the research progress on biomass gasification principle, gasification medium, and reactor in gasification technology of Chinese medicinal solid waste in recent years.

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Article Synopsis
  • Autonomous exoskeletons need to adjust their assistance based on walking speed to effectively reduce metabolic energy costs during movement.
  • A study was conducted with three participants walking at different speeds (1.0 m/s, 1.25 m/s, and 1.5 m/s) to analyze how optimized exoskeleton assistance impacts metabolic cost and muscle activity.
  • Results showed that exoskeleton assistance significantly decreased metabolic costs as walking speed increased, with the most effective assistance seen at medium and fast speeds, suggesting that exoskeletons may be less beneficial for slower walking conditions.
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Weight cycling is prevalent in sports/professions with body composition standards, and has been associated with weight management behaviours that may contribute to suboptimal diet quality and weight gain. US Army Soldiers may be at increased risk of weight cycling relative to civilians due to mandated body composition standards. However, the relationship between weight cycling, weight management behaviours, BMI and diet quality among Soldiers is unknown.

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The complete chloroplast genome of (Rose) D.R.Hunt.

Mitochondrial DNA B Resour

July 2020

College of Pharmacy, Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xi'an, China.

In this study, the complete chloroplast genome of (Rose) D.R.Hunt was investigated.

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Complete plastid genome of the Chinese medicinal herb subsp. (Paeoniaceae): characterization and phylogeny.

Mitochondrial DNA B Resour

January 2020

College of Pharmacy, Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xi'an, China.

The plastid genome (plastome) of the endemic Chinese medicinal herb subsp. (Paeoniaceae) was sequenced and investigated in this study. The complete plastome is 152,713 bp in length with the typical quadripartite structure, which consists of a large single-copy region (LSC, 84,419 bp), a small single-copy region (SSC, 16,982 bp), and a pair of inverted repeat regions (IRs, 25,656 bp).

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The complete chloroplast genome sequence of , an endangered Chinese medicinal plant ().

Mitochondrial DNA B Resour

November 2019

College of Traditional Chinese Medicine, Hebei University, Baoding, PR China.

is a valuable medicinal plant endemic to the Qinghai-Tibetan Plateau. It has been listed classified under the IUCN Red List categories of Vulnerable due to the low reproductive rate and heavy exploitation. In this study, the complete chloroplast (cp) genome of has been assembled using data from the whole-genome Illumina sequencing.

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Perturbation of the cellular redox state by stress conditions is sensed by redox-sensitive proteins so that the cell can physiologically respond to stressors. However, the mechanisms linking sensing to response remain poorly understood in plants. Here we report that the transcription factor bZIP68 underwent in vivo oxidation in Arabidopsis cells under oxidative stress which is dependent on its redox-sensitive Cys320 residue.

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Gut microbiome community dynamics are maintained by complex microbe-microbe and microbe-host interactions, which can be disturbed by stress. studies on the dynamics and manipulation of those interactions are costly and slow, but can be accelerated using fermentation. Herein, fermentation was used to determine how an acute stressor, a sudden change in diet, impacts inter-bacterial species competition for resistant starch-supplemented medium (RSM).

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Characterization of the complete chloroplast genome of medicinal plant (Polygonaceae).

Mitochondrial DNA B Resour

July 2019

College of Pharmacy, Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xi'an, China.

The complete chloroplast (cp) genome of Baill. was determined based on the Illumina Sequencing data. The cp genome is 161,563 bp in length.

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Here, a method to synthesize cellulose nanofiber biotemplated palladium composite aerogels is presented. Noble metal aerogel synthesis methods often result in fragile aerogels with poor shape control. The use of carboxymethylated cellulose nanofibers (CNFs) to form a covalently bonded hydrogel allows for the reduction of metal ions such as palladium on the CNFs with control over both nanostructure and macroscopic aerogel monolith shape after supercritical drying.

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Consumption of certain berries appears to slow postprandial glucose absorption, attributable to polyphenols, which may benefit exercise and cognition, reduce appetite and/or oxidative stress. This randomised, crossover, placebo-controlled study determined whether polyphenol-rich fruits added to carbohydrate-based foods produce a dose-dependent moderation of postprandial glycaemic, glucoregulatory hormone, appetite and ex vivo oxidative stress responses. Twenty participants (eighteen males/two females; 24 (sd 5) years; BMI: 27 (sd 3) kg/m2) consumed one of five cereal bars (approximately 88 % carbohydrate) containing no fruit ingredients (reference), freeze-dried black raspberries (10 or 20 % total weight; LOW-Rasp and HIGH-Rasp, respectively) and cranberry extract (0·5 or 1 % total weight; LOW-Cran and HIGH-Cran), on trials separated by ≥5 d.

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