Understanding Hip Contact Stress Based on Types of Physical Activity: A Systematic Review.

Background And Aims: High contact stresses involving the hip have been shown to increase the risk of developing hip osteoarthritis (OA). Although several risk factors have been identified for OA, a holistic approach to predicting contributed factors toward increased hip contact stresses have not been explored. This study was conducted to comprehensively understand the effects of physical activity on high hip contact stress as predisposing factors of OA.

Targeting intracellular cancer proteins with tumor-microenvironment-responsive bispecific nanobody-PROTACs for enhanced therapeutic efficacy.

Proteolysis targeting chimeras (PROTACs) are pivotal in cancer therapy for their ability to degrade specific proteins. However, their non-specificity can lead to systemic toxicity due to protein degradation in normal cells. To address this, we have integrated a nanobody into the PROTACs framework and leveraged the tumor microenvironment to enhance drug specificity.

Understanding level of Chinese traffic signage among children aged 7-11 years: A pilot study.

Road traffic injuries are one of the main causes of death among children. In recent years, the incidence and casualty rates of traffic accidents have increased year by year, which is a major challenge faced by safety organizations and governments in various countries, especially in developing countries. Among them, correct understanding of road traffic signs is a factor in reducing accidents.

Internal Perspectives on Visual Identities in Higher Education: A Case Study of Top-Ranked Universities in Indonesia.

Background: The neglect of visual identity (VI) at the organizational level within higher education institutions (HEIs) has become a critical issue, while previous studies over the past decade has focused on HEI branding and reputation. This creates a potential gap in understanding HEI branding processes. Thus, this study aims to explore the relationship between VI and HEI reputation by integrating the Expressiveness Quotient (EQ) and experiential brand meaning at the organizational level.

Preparation of an FA-Based Discoloration Material and Its Application in Jewelry Design.

Fly ash (FA) is the main solid waste emitted from coal-fired power plants. Due to its high yield, low utilization rate, and occupation of a large amount of land, it exerts enormous pressure on the Earth's environment. With the deepening of the concept of sustainable development, exploring the reuse of industrial waste such as FA has become a key strategy.

The Use of Card-Game Design to Teach Universal Design Theory.

This paper discusses the use of a card-game design task to teach the implementation of Universal Design (UD) principles to undergraduate students. The underlying assumption is that in order to implement UD methods, designers need to select the right tools to gather information and they need to understand the theoretical basis of the tools chosen. The aim is to bridge the theory/practice gap by getting students to actively consider how each aspect of their design research contribute to the implementation of the theory.

Developing improved crash prevention approaches through in-depth investigation of motorcycle crash causation patterns.

Despite advancements in road safety, Powered Two-Wheelers (PTWs) remain a vulnerable group with disproportionately high crash rates. This paper presents an in-depth analysis of PTW crashes in six European countries, with a case study of Loss of Control in Curves (LoCC), to address the gap between crash causation and prevention. By examining crash causation factors and their linkage to prevention strategies, the study illustrates various approaches for connecting causes and countermeasures.

Technology innovation to reduce health inequality in skin diagnosis and to improve patient outcomes for people of color: a thematic literature review and future research agenda.

The health inequalities experienced by ethnic minorities have been a persistent and global phenomenon. The diagnosis of different types of skin conditions, e.g.

Piezoelectric Outputs of Electrospun PVDF Web as Full-Textile Sensor at Different Mechanical Excitation Frequencies.

With the increasing application of electrospun PVDF webs in piezoelectric sensors and energy-harvesting devices, it is crucial to understand their responses under complex mechanical excitations. However, the dependence of the piezoelectric effect on mechanical excitation properties is not fully comprehended. This study aims to investigate the piezoelectric output of randomly oriented electrospun PVDF nanofiber webs fabricated through different electrospinning processes at various mechanical excitation frequencies.

Assessment and mapping of noise pollution in recreation spaces using geostatistic method after COVID-19 lockdown in Turkey.

Increased use of recreational areas after the lifting of COVID-19 pandemic restrictions has led to increased noise levels. This study aims to determine the level of noise pollution experienced in recreational areas with the increasing domestic and international tourism activities after the lifting of pandemic lockdowns, to produce spatial distribution maps of noise pollution, and to develop strategic planning suggestions for reducing noise pollution in line with the results obtained. Antalya-Konyaaltı Beach Recreation Area, the most important international tourism destination of Turkey, is determined as the study area.

Measuring paw preferences in dogs, cats and rats: Design requirements and innovations in methodology.

Studying behavioural lateralization in animals holds great potential for answering important questions in laterality research and clinical neuroscience. However, comparative research encounters challenges in reliability and validity, requiring new approaches and innovative designs to overcome. Although validated tests exist for some species, there is yet no standard test to compare lateralized manual behaviours between individuals, populations, and animal species.

Photophobia is associated with lower sleep quality in individuals with migraine: results from the American Registry for Migraine Research (ARMR).

Background: Patients with migraine often have poor sleep quality between and during migraine attacks. Furthermore, extensive research has identified photophobia as the most common and most bothersome symptom in individuals with migraine, second only to headache. Seeking the comfort of darkness is a common strategy for managing pain during an attack and preventing its recurrence between episodes.

The flow of anisotropic nanoparticles in solution and in blood.

The alignment of anisotropic nanoparticles in flow has been used for a range of applications such as the preparation of strong fibres and the assembly of in-plane aligned 1D-nanoobjects that are used for electronic devices, sensors, energy and biological application. Important is also the flow behaviour of nanoparticles that were designed for nanomedical applications such as drug delivery. It is widely observed that non-spherical nanoparticles have longer circulation times and a more favourable biodistribution.

EEGProgress: A fast and lightweight progressive convolution architecture for EEG classification.

Because of the intricate topological structure and connection of the human brain, extracting deep spatial features from electroencephalograph (EEG) signals is a challenging and time-consuming task. The extraction of topological spatial information plays a crucial role in EEG classification, and the architecture of the spatial convolution greatly affects the performance and complexity of convolutional neural network (CNN) based EEG classification models. In this study, a progressive convolution CNN architecture named EEGProgress is proposed, aiming to efficiently extract the topological spatial information of EEG signals from multi-scale levels (electrode, brain region, hemisphere, global) with superior speed.

Dynamic Causal Modeling and Online Collaborative Forecasting of Air Quality in Hong Kong and Macao.

The Hong Kong and Macao Special Administrative Regions, situated within China's Guangdong-Hong Kong-Macao Greater Bay Area, significantly influence and are impacted by their air quality conditions. Rapid urbanization, high population density, and air pollution from diverse factors present challenges, making the health of the atmospheric environment in these regions a research focal point. This study offers three key contributions: (1) It applied an interpretable dynamic Bayesian network (DBN) to construct a dynamic causal model of air quality in Hong Kong and Macao, amidst complex, unstable, multi-dimensional, and uncertain factors over time.

Using Nvivo to Analyze the Impact of Computer Simulation of Parent-Child Cooperative Art Activities on the Growth of Preschool Children.

Psychology originally defined parent-child conflict in terms of interpersonal relationships, where parent-child conflict is a process of inconsistent attitudes between parents and children that occurs in a family setting. For this end, we aims to investigate the influence of parental awareness on preschoolers' perception of parent-child conflict and the mediating role of preschoolers' self-esteem. This paper proposes a dynamic parent-child relationship discovery algorithm based on the impact of parent-child cooperation activities on preschool children's development.

Landscape design of colleges based on the concept of ecological protection-taking Jilin Communications Polytechnic as an example.

The new design concept of being human-centered and emphasizing the organic construction of the ecological environment is progressively gaining popularity because of the growing influence of ecology, green building, and environmental protection theories. By examining the landscape architecture of colleges and universities, this study aims to investigate the principles of ecological and environmental protection and to advance the development of the ecological environment on campus. As a result, this study uses Jilin Communications Polytechnic as an example to discuss the state of the research on campus landscape design in Jilin province and its significance, examines the process of campus landscape design under the concept of ecological and environmental protection after introducing the study object, assessment indexes, and constituent aspects of campus landscape design.

Testing the reliability of accident analysis methods: a comparison of AcciMap, STAMP-CAST and AcciNet.

Accident analysis methods are used to model the multifactorial cause of adverse incidents. Methods such as AcciMap, STAMP-CAST and recently AcciNet, are systemic approaches that support the identification of safety interventions across sociotechnical system levels. Despite their growing popularity, little is known about how reliable systems-based methods are when used to describe, model and classify contributory factors and relationships.

Relatively minor influence of individual characteristics on critical wet-bulb globe temperature (WBGT) limits during light activity in young adults (PSU HEAT Project).

Critical environmental limits are temperature-humidity thresholds above which heat balance cannot be maintained for a given metabolic heat production. This study examined the association between individual characteristics [sex, body surface area (A), aerobic capacity (V̇o), and body mass (m)] and critical environmental limits in young adults at low metabolic rates. Forty-four (20 M/24 F; 23 ± 4 yr) subjects were exposed to progressive heat stress in an environmental chamber at two low net metabolic rates (M); minimal activity (MinAct; M = ∼160 W) and light ambulation (LightAmb; M = ∼260 W).