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Introduction: Erythema nodosum leprosum (ENL) is a type of lepra reaction treated with corticosteroids and thalidomide, but this association increases the risk of deep venous thrombosis (DVT).

Objective: To report cases of ENL with DVT in the use of thalidomide/corticosteroid associated.

Methodology: The study was conducted between December 2015 and December 2016 at the Eduardo de Menezes Hospital (HEM-FHEMIG).

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