875 results match your criteria: "Dermatologic Manifestations of Hematologic Disease"
Rare Case of Germline GATA2-Deficiency With Merkel Cell Carcinoma and Acute Myeloid Leukemia.
Cancer Rep (Hoboken)
December 2024
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Article Synopsis
Beyond the Surface: A Unique Presentation of Acute Promyelocytic Leukemia as Idiopathic Intracranial Hypertension: A Case Report.
Cancer Rep (Hoboken)
November 2024
Student Research Committee, Clinical Research Development Unit of Imam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran.
Article Synopsis
[Hypereosinophilic syndrome, case report and diagnostic approach].
Rev Med Inst Mex Seguro Soc
March 2024
Instituto Mexicano del Seguro Social, Hospital General de Zona No. 47 Vicente Guerrero, Servicio de Medicina Interna. Ciudad de México, México.
Article Synopsis
- - *Hypereosinophilic syndrome (HES) is a rare blood disorder that leads to high levels of eosinophils, which can cause damage to various tissues, often discovered incidentally due to its asymptomatic onset.* - *A clinical case involving a 69-year-old male with chronic conditions showed symptoms like skin lesions and blood abnormalities, leading to a diagnosis of idiopathic HES after further testing confirmed eosinophilic infiltration.* - *Eosinophilic disorders can have various clinical signs, especially skin-related issues, and are linked to chronic kidney disease; hence, early diagnosis and treatment are essential for better patient outcomes.*
The Constellation of Risk Factors and Paraneoplastic Syndromes in Cholangiocarcinoma: Integrating the Endocrine Panel Amid Tumour-Related Biology (A Narrative Review).
Biology (Basel)
August 2024
Department of Internal Medicine and Gastroenterology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Article Synopsis
- - Cholangiocarcinomas (CCAs) are complex malignant tumors from the biliary epithelium, with increasing global incidence and various risk factors such as chronic liver diseases, lifestyle choices, and genetic factors
- - The review highlights the endocrine features related to CCAs, including associations with conditions like obesity and diabetes, alongside various paraneoplastic syndromes that manifest in patients
- - Humoral hypercalcemia is noted as the most common paraneoplastic syndrome in CCAs, signaling poor prognosis and requiring treatment beyond the typical cancer therapy
Methotrexate-induced leukoencephalopathy presenting as acute-onset limb weakness in a child: a case report.
J Med Case Rep
September 2024
Colombo North Teaching Hospital, Ragama, Sri Lanka.
Article Synopsis
- Methotrexate is a key medication for treating childhood cancers like acute lymphoblastic leukemia but can lead to severe side effects such as neurotoxicity, specifically leukoencephalopathy, which usually presents with gradual neurological symptoms.
- A case involving a 10-year-old boy showed acute neurological symptoms, including limb weakness and involuntary movements, after taking oral methotrexate, a rare occurrence compared to traditional administration routes like injection.
- MRI scans revealed brain abnormalities consistent with methotrexate-induced neurotoxicity, highlighting the need for careful monitoring of neurological effects even with oral use of the drug.
A case report of minimal change disease associated with Kimura disease complicated by optic neuritis.
Nephrology (Carlton)
November 2024
Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.
Article Synopsis
Association of bullous pemphigoid with acquired hemophilia A: a case report.
Pan Afr Med J
September 2024
Department of Clinical Hematology and Bone Marrow Transplantation, University Hospital Centre Mohammed VI, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh, Morocco.
Article Synopsis
- * A case study of a 31-year-old woman with bullous pemphigoid (an autoimmune skin condition) who had been treated with corticosteroids revealed spontaneous bleeding and laboratory results indicating acquired hemophilia A, including low factor VIII levels and prolonged blood clotting times.
- * This situation emphasizes the need to consider acquired hemophilia A in patients with autoimmune diseases like bullous pemphigoid, particularly when they experience unexpected bleeding, showing a connection between autoimmune conditions and blood coagulation issues.
A Comprehensive Review of Ocular Manifestations in Systemic Diseases.
Cureus
July 2024
Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- * The review covers various diseases, like cardiovascular and autoimmune disorders, and their specific eye-related symptoms, along with diagnostic methods like eye exams and lab tests.
- * It also discusses management strategies and emerging treatments, stressing the importance of a collaborative healthcare approach to improve patient outcomes.
Distinctive features associated with differentiation syndrome in acute promyelocytic leukemia in patients treated by all-trans retinoic acid and arsenic trioxide.
Leuk Res
October 2024
National Cancer Institute, Bratislava, Slovakia, Oncohematology Department, Slovakia; Faculty of Medicine Comenius University, Slovakia.
Article Synopsis
- In acute promyelocytic leukemia (APL), combining all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) shows a unique effect on differentiation syndrome (DS), making it different from the previously recognized ATRA syndrome due to its specific symptoms and patterns.
- A study from 2013-2022 categorized APL patients into three treatment groups and analyzed the occurrence of leukocytosis and DS within the first 25 days, finding a 43.8% incidence of DS and elevated liver enzymes in the ATRA/ATO standard-risk group.
- The results suggest that liver changes may be linked to the treatment's effects on leukocyte differentiation and call for a reevaluation of the DS definition and
Approaches for the diagnosis and treatment of VEXAS syndrome: the importance of clinical suspicion and the use of methotrexate.
Ann Hematol
November 2024
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Vacuoles, E1-enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome is caused by mutations in the UBA1 gene in myeloid precursors, leading to systemic inflammatory manifestations. We present the case of a 75-year-old man presenting with fever, panniculitis, and macrocytic anemia testing repeatedly negative for UBA1 mutations in peripheral blood samples, but ultimately found positive on bone marrow mononuclear cell DNA. The man has been successfully treated with prednisone and methotrexate.
View Article and Find Full Text PDFCase report of renal manifestations in X-linked agammaglobulinemia.
Front Immunol
August 2024
Department of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Article Synopsis
- X-linked agammaglobulinemia (XLA) is a condition where individuals have recurrent infections and low levels of antibodies due to a lack of B cells, and while it's rare, renal issues can occur.
- This article presents two cases of twin brothers with XLA who experienced respiratory infections and renal complications, with varying treatment responses due to financial constraints.
- The study emphasizes the importance of genetic testing and immune profiling in diagnosing XLA in boys with recurring infections, as well as the need for regular monitoring for kidney issues in these patients.
Biologic therapy for ulcerative colitis associated with immune thrombocytopenia.
Clin J Gastroenterol
October 2024
Division of Gastroenterology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Article Synopsis
- Ulcerative colitis (UC) can sometimes lead to issues outside the intestines, such as immune thrombocytopenia (ITP), a condition where platelet levels drop.
- A 51-year-old man with severe UC and ITP did not respond to standard treatments, but treatment with biologic drugs like ustekinumab and adalimumab helped him achieve remission in both conditions.
- This case highlights how effective biologics can be in treating difficult UC cases accompanied by ITP, suggesting they might help avoid the need for surgery.
Noninfectious Complications in B-Lymphopenic Common Variable Immunodeficiency.
J Investig Allergol Clin Immunol
July 2024
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran University of Medical Science, Tehran, Iran.
Article Synopsis
- Common variable immunodeficiency (CVID) is a significant disorder characterized by both infectious and noninfectious complications, with 66.4% of patients experiencing noninfectious issues such as enteropathy and autoimmunity.
- In a study of 387 CVID patients, those with B-cell lymphopenia showed higher rates of certain complications, particularly in the dermatologic, endocrine, and musculoskeletal systems.
- The study highlights the need for routine monitoring and appropriate treatment strategies, including medication alongside immunoglobulin therapy, to manage complications associated with CVID effectively.
Dermatological conditions in the intensive care unit at a tertiary care hospital in Riyadh, Saudi Arabia.
Saudi Med J
August 2024
From the College of Medicine (Altammami, Alswayed, AlJasser, Alkhodair), King Saud bin Abdulaziz University for Health Sciences, from the Department of Dermatology (AlJasser, Alkhodair), King Abdullah International Medical Research Center, from the Division of Dermatology (AlJasser), Ministry of National Guard Health Affairs, and from the Division of Pediatric Dermatology (Alkhodair), Department of Pediatrics, King Abdullah Specialist Children's Hospital, Riyadh, Kingdom of Saudi Arabia.
Article Synopsis
- The study aimed to examine skin conditions in patients admitted to the ICU, analyzing both those who developed dermatological issues during their stay and those whose conditions necessitated ICU care.
- A total of 344 patients were reviewed, revealing 365 distinct dermatological conditions, with the most common issues being skin infections, inflammatory diseases, and drug reactions.
- Key findings highlighted morbilliform drug eruption, contact dermatitis, and vasculitis as the top dermatological disorders observed among ICU patients.
Treatment of Iron-Induced Cutaneous Hyperpigmentation With Energy-Based Devices.
Lasers Surg Med
September 2024
Department of Dermatology, University of California, Irvine, Irvine, California, USA.
Article Synopsis
- Iatrogenic cutaneous siderosis is a skin condition characterized by dark patches near injection sites from iron infusions, causing aesthetic and psychological issues for patients, and often doesn't resolve on its own.
- A systematic review of the effectiveness of energy-based devices to treat this condition included 54 female patients, mostly around 44 years old, primarily affected after intravenous iron infusion for iron deficiency anemia.
- Six different laser systems were analyzed, showing over half of patients experienced complete clearance after an average of 5.4 treatments, with the Nd:YAG 532 nm laser showing the best results in the case discussed.
Dyskeratosis congenita associated with a novel missense variant in TERT: Approach for the dermatologists.
Arch Dermatol Res
June 2024
Department of Biosciences, Universidad de La Sabana, Campus Puente Común, Km. 7, Autopista Norte de Bogotá, Chía, Colombia.
Article Synopsis
- * In this study, genetic sequencing was performed on a patient with DC, and their information was compared with leading genetic databases to confirm findings.
- * The authors discovered a new variant of DC and provided 10 practical recommendations for dermatologists and other healthcare professionals to aid in managing patients with this condition.
Blast from the Past: Acute Myeloid Leukemia Presenting with Cardiac Tamponade.
R I Med J (2013)
July 2024
Warren Alpert Medical School of Brown University, Rhode Island Hospital, Department of Hematology and Oncology, Providence, R.
Article Synopsis
- Acute Myeloid Leukemia (AML) is a serious condition that often manifests with symptoms like fevers, fatigue, and respiratory issues, necessitating quick diagnosis and treatment.
- A rare initial presentation of AML can involve cardiac tamponade, a condition where fluid accumulates around the heart, leading to serious complications.
- In this case study, a 58-year-old man with a history of cardiac tamponade was diagnosed with AML after finding a high percentage of myeloblasts in his bone marrow, and his heart symptoms improved following leukemia treatment.
Acquired Amegakaryocytic Thrombocytopenia Misdiagnosed as Immune Thrombocytopenia in a Patient with Seronegative Arthritis: A Case Report.
J Assoc Physicians India
November 2023
Junior Resident, Department of General Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India, Corresponding Author.
Article Synopsis
- - Acquired amegakaryocytic thrombocytopenia (AATP) is a rare condition leading to very low platelet counts while preserving other blood cell types, causing serious bleeding issues.
- - A 45-year-old man with seronegative arthritis received treatment for immune thrombocytopenic purpura (ITP), but his platelet levels remained low, prompting a bone marrow biopsy.
- - The biopsy revealed AATP, and the patient was successfully treated with cyclosporine; accurately identifying AATP is critical, as it can result in severe complications like bleeding, aplastic anemia, or myelodysplastic syndromes.
Congenital erythropoietic porphyria.
Liver Int
August 2024
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Article Synopsis
- Congenital erythropoietic porphyria (CEP) is a rare genetic disorder caused by reduced function of the UROS enzyme, leading to the accumulation of harmful porphyrins.
- The buildup of these porphyrins mainly affects blood and skin, causing symptoms that can range from severe fetal conditions to mild skin issues in adults.
- The text discusses the biochemical and clinical aspects of CEP, alongside current and potential new treatments aimed at improving UROS enzyme activity.
Dermatologic manifestations of hematologic disorders.
Ann Hematol
October 2024
Division of Hematology and Medical Oncology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road Mail Code: OC14HO, 97239, Portland, OR, USA.
Article Synopsis
- - Understanding the visual characteristics and causes of skin issues related to blood disorders is crucial for timely treatment and can help diagnose underlying conditions.
- - Skin symptoms often indicate problems with blood coagulation, blood vessels, or skin infiltration, making it important for hematologists to recognize these signs.
- - This review focuses on both common and severe skin manifestations linked to blood disorders, highlighting the need for teamwork among medical professionals to provide the best care for patients.
A Life-Threatening Complication During the Fourth Pregnancy Due to Acute Promyelocytic Leukemia: A Case Report.
Acta Med Indones
January 2024
Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia.
Article Synopsis
- Leukemia during pregnancy is rare, occurring in about 1 in 75,000 to 100,000 pregnancies, and if it occurs, it's usually an acute form, often myeloid.
- A case involved a 35-year-old woman in her late pregnancy presenting with contractions and diagnosed through bone marrow aspiration with Acute Promyelocytic Leukemia (APL).
- Treatment includes the use of All-Trans Retinoic Acid (ATRA) and Arsenic Trioxide (ATO), which are teratogenic but have not shown significant fetal abnormalities, making timely diagnosis and care crucial to avoid complications.*
Case Report: Minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review.
Front Pharmacol
March 2024
Department of Pharmacy, Peking University Third Hospital, Beijing, China.
Minocycline is a tetracycline commonly used for several dermatological diseases. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but severe adverse event which can be caused by minocycline. An 18-year-old male patient developed fever, acute rash, pharyngeal pain, lymphadenopathy, hematologic abnormalities, increased creatinine level, elevated liver enzyme levels, and splenomegaly 4 weeks after the oral treatment of minocycline, 100 mg daily, for acne.
View Article and Find Full Text PDFNeurologic Complications of the Central Nervous System after Allogeneic Stem Cell Transplantation: The Role of Transplantation-Associated Thrombotic Microangiopathy as a Potential Underreported Cause.
Transplant Cell Ther
June 2024
Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany.
Article Synopsis
- * A study compared the effects of two calcineurin inhibitors (CNIs), cyclosporin A (CsA) and tacrolimus (TAC), on the incidence and type of CNS-NCs in patients with high-risk hematologic malignancies who underwent allo-HSCT over 20 years.
- * Findings indicated that CNS-NCs occurred in 17% of patients and correlated with lower overall survival and higher mortality rates; TAC was identified as a key risk factor for CNS-N
A case of Bloom syndrome manifesting with therapy-related myelodysplastic syndromes harboring a novel BLM gene variant.
Int J Hematol
May 2024
Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Article Synopsis
- Bloom syndrome (BS) is a rare genetic disease caused by changes in the BLM gene, which helps keep our genes stable and healthy.
- People with BS have unique facial features, longer limbs, and skin problems like sensitivity to sunlight.
- A 34-year-old woman with BS had a history of different cancers and passed away at 35; genetic tests showed she had two different harmful changes in the BLM gene.
Antiphospholipid antibodies as potential predictors of disease severity and poor prognosis in systemic lupus erythematosus-associated thrombocytopenia: results from a real-world CSTAR cohort study.
Arthritis Res Ther
March 2024
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Ministry of Education, Beijing, 100730, China.
Article Synopsis
- The study aimed to explore how antiphospholipid antibodies (aPLs) affect the severity and prognosis of thrombocytopenia in patients with systemic lupus erythematosus (SLE).
- Researchers analyzed data from 350 SLE-TP patients, finding that those with aPLs had significantly lower platelet counts and a higher incidence of moderate to severe cases compared to those without aPLs.
- Patients with aPLs also experienced higher relapse rates and lower rates of achieving complete response during follow-up, indicating a more severe disease trajectory associated with the presence of aPLs.