344 results match your criteria: "Dermatologic Manifestations of Cardiac Disease"
Cardiac involvement in dermatological disorders: A narrative review.
Indian J Dermatol Venereol Leprol
November 2024
Department of Dermatology, Venereology & Leprology. All India Institute of Medical Sciences, Rajkot, Gujarat, India.
Article Synopsis
- - Recent studies reveal a strong link between skin disorders and heart issues, with dermatologists often finding serious cardiac conditions like septal defects and cardiomyopathy in patients with certain genetic skin diseases.
- - A thorough literature review was conducted using articles from PubMed and Google Scholar, focusing on various skin disorders that also show cardiac effects, including congenital diseases and drug reactions.
- - Recognizing these cardiac manifestations is essential for proper treatment, timely interventions, and effective communication with patients about their health concerns.
Cutaneous Dermatologic Manifestations of Cardiovascular Diseases: A Narrative Review.
Cureus
October 2024
Department of Research, Fondazione Paolo Procacci, Rome, ITA.
Cardiovascular diseases represent the largest worldwide cause of morbidity and mortality. Common signs and symptoms of cardiovascular disease are well characterized and taught in medical curricula, allowing clinicians to quickly recognize and diagnose the more acute and emergent cardiovascular diseases. Dermatological features associated with cardiovascular diseases are less understood but very valuable to appreciate in clinical practice.
View Article and Find Full Text PDFDesmoplakin Cardiomyopathy in Pediatric Patients: A Distinct, Underrecognized Cohort of Arrhythmogenic Cardiomyopathy.
Circ Arrhythm Electrophysiol
November 2024
Division of Pediatric Cardiology, Morgan Stanley Children's Hospital of New York-Presbyterian, Columbia University Medical Center (N.H.C., L.L., E.S.S., T.M.L., W.A.Z.).
Background: cardiomyopathy is a distinct subset of arrhythmogenic cardiomyopathy, reported primarily in adults, that has predominantly left ventricular involvement and features of myocarditis. Clinical characteristics, risk stratification, and management of pediatric patients with variants are not well known. We sought to identify phenotypic features and prognosis of pediatric patients with pathogenic or likely pathogenic variants.
View Article and Find Full Text PDFBridging Hospital Resource Variability: Adapting the Escape Room to Integrate Procedure Teaching for Emergency Medicine Trainees in India.
J Educ Teach Emerg Med
October 2024
University of Kentucky, Department of Emergency Medicine, Lexington, KY.
Article Synopsis
- The in-person escape room activity focuses on the complexities of HIV management in India, aimed at Emergency Medicine trainees and other medical specialties needing HIV knowledge.
- It addresses the various reasons patients with HIV visit the Emergency Department and emphasizes the need for EM providers to be skilled in managing HIV despite advancements in treatment.
- By participating, learners will enhance their understanding of antiretroviral therapies, including prescribing them for new HIV diagnoses.
Polyarteritis nodosa mimics Kawasaki disease.
BMJ Case Rep
October 2024
Pediatrics, Umm Al-Qura University College of Medicine, Makkah, Saudi Arabia
Polyarteritis nodosa (PAN) is a rarely seen vasculitis that often affects small-sized and medium-sized arteries. PAN can present with diverse clinical features depending on the organs involved, including potential cardiac involvement. Typical cardiac manifestations of PAN in the paediatric age group include pericarditis, valvular heart disease and coronary artery aneurysms.
View Article and Find Full Text PDFClinical features of Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuritis associated with SLE.
Lupus Sci Med
October 2024
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Article Synopsis
- - The study examined 9 patients with Systemic Lupus Erythematosus (SLE) who also had Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyradiculoneuritis (CIDP), analyzing their clinical characteristics and outcomes over a 17-year period.
- - Among the patients, 6 had SLE with GBS and 3 had SLE with CIDP, with common symptoms including limb weakness and neurological issues like dysphagia and facial nerve palsy.
- - Treatments included glucocorticoids, immunoglobulin therapy, and other immunosuppressants, leading to varied outcomes, highlighting the importance of proper diagnosis and treatment approaches in SLE-related
Systemic Sclerosis With Cardiac Manifestations: A Case Report.
Cureus
July 2024
Internal Medicine, Atrium Health Navicent The Medical Center, Macon, USA.
Article Synopsis
- Systemic sclerosis (SSc), also known as scleroderma, can lead to serious organ damage if not diagnosed or treated properly; some symptoms are well-researched, while others still need further exploration.
- A case report describes a newly diagnosed scleroderma patient experiencing worsening breathlessness and low activity tolerance, ultimately revealing heart conduction issues like a prolonged PR interval and conduction blocks.
- The patient received a thorough evaluation and was treated by a multidisciplinary team, highlighting the importance of recognizing less common symptoms of SSc for effective diagnosis and management.
Decoding the muscle transcriptome of patients with late-onset Pompe disease reveals markers of disease progression.
Brain
December 2024
The John Walton Muscular Dystrophy Research Centre, Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne NHS Trust, Newcastle Upon Tyne, NE13BZ, UK.
Article Synopsis
- Late-onset Pompe Disease (LOPD) is a rare genetic disorder caused by a deficiency in an enzyme, leading to muscle damage and glycogen accumulation in cells.
- This study used advanced techniques like single nuclei RNA sequencing to explore gene expression changes in muscle biopsies from LOPD patients compared to healthy controls, revealing significant metabolic shifts and inflammatory responses in affected fibers.
- Findings suggest potential benefits of enzyme replacement therapy in restoring metabolic function, especially in healthy muscle fibers, emphasizing the importance of using modern methods to understand muscle disease at a cellular level.
Coronary periarteritis and pericarditis are rare but distinct manifestations of heart involvement in IgG4-related disease: a retrospective cohort study.
Orphanet J Rare Dis
July 2024
Department of Rheumatology, Peking Union Medical College Hospital National Clinical Research Center for Dermatologic and Immunologic Diseases Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Article Synopsis
- The heart can be affected by a disease called IgG4-related disease (IgG4-RD), which is rare but important to study.
- In a study of 42 patients, researchers looked at the heart problems caused by this disease and how well treatments worked.
- Most patients responded well to treatments like glucocorticoids, but some had relapses, showing that careful monitoring is needed even after treatment.
Febrile ulceronecrotic Mucha-Habermann disease - a case and treatment review.
Dermatol Online J
April 2024
Departamento de Medicina, Servico de Medicina Interna, Unidade Local de Saude de Matosinhos EPE, Portugal.
Article Synopsis
- * It often leads to serious complications including issues in the blood, lungs, heart, gut, and brain.
- * Treatment typically involves corticosteroids and immunosuppressants like methotrexate, with a case presented showing a gradual treatment strategy for a patient not responding well to methotrexate.
Blast from the Past: Acute Myeloid Leukemia Presenting with Cardiac Tamponade.
R I Med J (2013)
July 2024
Warren Alpert Medical School of Brown University, Rhode Island Hospital, Department of Hematology and Oncology, Providence, R.
Article Synopsis
- Acute Myeloid Leukemia (AML) is a serious condition that often manifests with symptoms like fevers, fatigue, and respiratory issues, necessitating quick diagnosis and treatment.
- A rare initial presentation of AML can involve cardiac tamponade, a condition where fluid accumulates around the heart, leading to serious complications.
- In this case study, a 58-year-old man with a history of cardiac tamponade was diagnosed with AML after finding a high percentage of myeloblasts in his bone marrow, and his heart symptoms improved following leukemia treatment.
A Comprehensive Review of Lyme Disease: A Focus on Cardiovascular Manifestations.
Cureus
May 2024
Rheumatology, Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, USA.
Article Synopsis
- * Atypical cardiac symptoms, such as atrial fibrillation and bundle branch blocks, may also occur and can be the first signs of Lyme disease in some patients.
- * A literature review of 13 articles was conducted to better understand these atypical cardiac manifestations and their underlying mechanisms, aiming to improve early diagnosis and treatment to reduce long-term complications.
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Phytomedicine
July 2024
Luoyang Key Laboratory of Clinical Multiomics and Translational Medicine, Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China. Electronic address:
Background: The study of cardiotoxicity of drugs has become an important part of clinical safety evaluation of drugs. It is commonly known that podophyllotoxin (PPT) and its many derivatives and congeners are broad-spectrum pharmacologically active substances. Clinical cardiotoxicity of PPT and its derivatives has been raised, basic research on the mechanism of cardiotoxicity remains insufficient.
View Article and Find Full Text PDFOcular Manifestation in Systemic Sclerosis-A Literature Review.
Life (Basel)
May 2024
Opthalmology Department, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland.
Article Synopsis
- * There are two main types of scleroderma: limited cutaneous SSc and diffuse cutaneous SSc, both of which can lead to serious issues in vital organs including respiratory, cardiac, renal, and ocular systems.
- * Ocular complications from scleroderma can affect both the front (anterior) and back (posterior) of the eye, causing issues like dry eye syndrome, eyelid changes, and abnormalities in the retinal blood vessels and optic nerve.
Cluster analysis of clinical phenotypes in idiopathic inflammatory myopathy patients complicated with cardiac involvement.
Clin Rheumatol
July 2024
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Shuai-Fu-Yuan, Dongcheng District, Beijing, 100730, China.
Article Synopsis
- - The study aimed to classify idiopathic inflammatory myopathy patients with cardiac involvement (IIM-CI) into two distinct categories based on their clinical characteristics and examine their outcomes over several years at Peking Union Medical College Hospital.
- - A total of 88 patients were analyzed, resulting in two categories: Category I showed significant heart issues and higher rates of arrhythmia and pulmonary hypertension, while Category II had more systemic symptoms and skeletal muscle weakness.
- - The findings indicated that heart failure was the leading cause of death for Category I patients, whereas severe pneumonia was the main cause of death for those in Category II, highlighting the differing health risks associated with each category.
Unexpected discovery of renal mass in a patient with granulomatosis with polyangiitis: accidental or inevitable?
Clin Exp Rheumatol
April 2024
Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH); Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Article Synopsis
- Granulomatosis with polyangiitis (GPA) is a rare autoimmune disorder affecting mainly the respiratory system and kidneys, causing symptoms like sinusitis and rapidly progressive kidney disease.
- The disorder can also impact other body parts, including skin, eyes, heart, joints, and the nervous system.
- The text discusses two hospital cases featuring atypical symptoms like fever and renal masses, outlining the clinical progression and supporting literature on these unusual manifestations.
Skin Changes in Suspected Lyme Disease.
Acta Dermatovenerol Croat
December 2023
Pero Vržogić, MD, Naftalan Special Hospital for Medical Rehabilitation, Ivanić Grad, Croatia;
Article Synopsis
- Ticks are a significant health concern in Croatia and worldwide due to their role in transmitting various diseases, including Lyme borreliosis, which is caused by the Borrelia burgdorferi bacterium.
- In Croatia, the incidence rate of Lyme borreliosis is approximately 6.51 cases per 100,000 people, highlighting the risk of infection from ticks.
- The article describes a case of a 58-year-old woman with Lyme disease who had skin manifestations that fully regressed after successful treatment, demonstrating the importance of early diagnosis and intervention.
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.
Nat Immunol
May 2024
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Article Synopsis
- The linear ubiquitin assembly complex (LUBAC), made up of HOIP, HOIL-1, and SHARPIN, is crucial for immune responses, with deficiencies leading to severe issues like immunodeficiency and autoinflammation.
- Two individuals with SHARPIN deficiency exhibited autoinflammatory symptoms but did not have the expected skin problems seen in other cases, and their cells showed reduced immune responses.
- Treatment with anti-TNF therapies successfully resolved the autoinflammatory symptoms in one case, highlighting LUBAC's important role in managing immune cell death and maintaining immune balance in humans.
Patient-reported experience with Fabry disease and its management in the real-world setting: results from a double-blind, cross-sectional survey of 280 respondents.
Orphanet J Rare Dis
April 2024
Emory University School of Medicine, Atlanta, GA, USA.
Article Synopsis
- * An online survey completed by 280 adults with FD revealed common symptoms like fatigue, pain, and hearing issues, with many finding their symptoms bothersome and difficult to manage.
- * Despite receiving treatment, nearly half of respondents experienced temporary symptom worsening and only a fraction communicated these changes to their doctors, with some receiving adjustments to their treatment as a result.
Alternations in the human skin, gut and vaginal microbiomes in perimenopausal or postmenopausal Vulvar lichen sclerosus.
Sci Rep
April 2024
Department of Dermatology, Peking University International Hospital, Life Park Road No.1 Life Science Park of Zhong Guancun, Chang Ping District, Beijing, People's Republic of China.
Article Synopsis
- Vulvar lichen sclerosus (VLS) is a chronic skin condition leading to physical and emotional challenges, but its cause is still unclear, with possible links to the microbiomes of the vulvar skin, gut, and vagina.* -
- A study compared the microbiota of six VLS patients with five healthy controls, using sequencing techniques to evaluate differences in bacterial diversity and abundance.* -
- Results showed notable microbiota differences, such as increased specific bacteria in VLS patients’ vulvar skin and gut, while certain beneficial bacteria were reduced, indicating potential microbial alterations linked to the condition.*
Dermatological manifestations in Costello syndrome: A prospective multicentric study of 31 HRAS-positive variant patients.
J Eur Acad Dermatol Venereol
September 2024
Department of Clinical Genetics, Pellegrin University Hospital of Bordeaux, Bordeaux, France.
Article Synopsis
- The study aimed to clarify the dermatological features of Costello syndrome (CS) and distinguish them from other similar syndromes like cardiofaciocutaneous syndrome (CFCS) and types of Noonan syndrome (NS).
- A ten-year multi-center study involving 31 patients found common skin and hair anomalies in CS, such as excessive eyebrows and various types of skin growths, which can help differentiate CS from CFCS and NS.
- The findings propose multiple melanocytic naevi as a potential marker for a milder form of CS and suggest that acitretin could be beneficial for treating certain skin conditions, although no clear genotype-phenotype link was identified.
Limb, sex, but not acute dietary capsaicin, modulate the near-infrared spectroscopy-vascular occlusion test estimate of muscle metabolism.
Physiol Rep
March 2024
Health and Human Physiological Sciences Department, Skidmore College, Saratoga Springs, New York, USA.
Article Synopsis
- The study aims to understand whether the NIRS-vascular occlusion test (NIRS-VOT) shows differences in muscle metabolism based on sex and limb while also examining the impact of dietary capsaicin on metabolic estimates during the test.
- Results showed significant differences in tissue desaturation rates (DeO) between limbs, with the quadriceps showing higher rates than the forearm, and between sexes, with women having higher DeO than men.
- Capsaicin, while tested for its effects on muscle metabolism, did not produce clear changes, but interactions involving limb type, sex, and capsaicin were noted.
Performance validation of the 2023 American College of Rheumatology/European League Against Rheumatism antiphospholipid syndrome classification criteria in an antiphospholipid syndrome cohort.
J Thromb Haemost
June 2024
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science and Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. Electronic address:
Article Synopsis
- The 2023 ACR/EULAR antiphospholipid syndrome (APS) classification criteria were created with improved specificity but slightly lower sensitivity compared to the 2006 criteria.
- A study involving 526 patients validated these new criteria against expert consensus, showing that while the 2023 criteria had higher specificity (98.3%), their sensitivity was somewhat reduced (81.8%).
- The new criteria performed better for specific groups like those with systemic lupus erythematosus and microvascular issues, but their lower sensitivity was due to stricter definitions and exclusions in the criteria.