1,470 results match your criteria: "Dermatochalasis"
Effectiveness of comprehensive approach in rejuvenating the aging lower periorbita.
Int Ophthalmol
December 2024
Department of Ophthalmology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Purpose: To investigate the efficacy of a comprehensive surgical approach for rejuvenation of the aging lower periorbita.
Methods: Between February 2018 and January 2023, 80 eyes of 40 patients with lower lid dermatochalasis (LLD), lower lid laxity (LLL) or orbicularis laxity of the lower lid (OL) admitted to the oculoplastic surgery department of our clinic were included in the study. 18 eyes had LLD, 14 eyes had LLL, 18 eyes had LLD and LLL, and 30 eyes had LLD, LLL and OL.
Modified Infrabrow Blepharoplasty for Periorbital Rejuvenation in Asia Women.
J Craniofac Surg
December 2024
Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou.
Objective: The infrabrow blepharoplasty is a common surgical operation indicated in Asians for periorbital rejuvenation. This operation alone is difficult to achieve the correction of crow's feet. Therefore, the authors elucidate the authors' experiences of applying infrabrow blepharoplasty combined with the subcutaneous undermining of the lateral periorbital region to treat upper eyelid dermatochalasis with lateral hooding deformity and alleviate crow's feet, including its indications, operative procedures, and postoperative outcomes.
View Article and Find Full Text PDFAblative radiofrequency microplasma for lateral dermatochalasis-indications and treatment recommendations.
Lasers Med Sci
December 2024
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
To determine in which cases ablative radiofrequency microplasma is preferred for the treatment of lateral dermatochalasis over a surgical approach as well as discussing each method's benefits and limitations. Twenty-one patients underwent 3 interventions of plasma exeresis. Photographic and RCM images were acquired at baseline and 4 weeks after final plasma exeresis.
View Article and Find Full Text PDFGolgi pH elevation due to loss of V-ATPase subunit V0a2 function correlates with tissue-specific glycosylation changes and globozoospermia.
Cell Mol Life Sci
December 2024
Institute of Human Genetics, University Medical Center Göttingen, 37073, Göttingen, Germany.
Loss-of-function variants in ATP6V0A2, encoding the trans Golgi V-ATPase subunit V0a2, cause wrinkly skin syndrome (WSS), a connective tissue disorder with glycosylation defects and aberrant cortical neuron migration. We used knock-out (Atp6v0a2) and knock-in (Atp6v0a2) mice harboring the R755Q missense mutation selectively abolishing V0a2-mediated proton transport to investigate the WSS pathomechanism. Homozygous mutants from both strains displayed a reduction of growth, dermis thickness, and elastic fiber formation compatible with WSS.
View Article and Find Full Text PDFEffect of upper eyelid blepharoplasty with or without orbicularis oculi muscle removal on anterior segment parameters, keratometry, and ocular biometry.
Int Ophthalmol
December 2024
Clinic of Ophthalmology, Mersin State Hospital, Mersin, Turkey.
Purpose: To evaluate the effect of upper eyelid blepharoplasty with or without the removal of a strip of orbicularis oculi muscle on corneal topographic parameters, anterior segment parameters, intraocular pressure, and ocular biometry.
Method: This prospective study examined 428 eyes of 214 patients with dermatochalasis. Patients were divided into two groups randomly: those who underwent orbicularis oculi muscle excision (Group 1) during blepharoplasty and those who did not (Group 2).
Quantitative Assessment of New Frontiers in Dermatochalasis and Periorbital Hyperpigmentation Treatment: The Role of Cross-Linked Porcine Collagen.
Aesthetic Plast Surg
December 2024
Sorbonne Université, Paris 6, 15-21 Rue de l'École de Médecine, 75006, Paris, France.
Article Synopsis
- This text outlines that authors must assign a level of evidence to their articles submitted to the journal.
- It specifically states that the level mentioned is IV, which suggests it’s the lowest tier in the evidence ranking.
- For more details about evidence-based ratings, authors should refer to the journal’s Table of Contents or the online guidelines provided by Springer.
Acquired Cutis Laxa Type 2 (Marshall's Syndrome) Associated with Sweet's Syndrome: A Rare Entity.
Indian J Dermatol
October 2024
From the Department of Dermatology, and Venereology, S.C.B. Medical College and Hospital, Cuttack, Odisha, India E-mail:
Acquired generalised cutis laxa with visceral involvement in a patient with rheumatoid arthritis and monoclonal gammopathy of uncertain significance.
Indian J Dermatol Venereol Leprol
April 2024
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Phenotypic findings associated with variation in elastin.
HGG Adv
November 2024
Department of Genomic Health, Geisinger, Danville, PA, USA. Electronic address:
Variation in the elastin gene (ELN) may contribute to connective tissue disease beyond the known disease associations of supravalvar aortic stenosis and cutis laxa. Exome data from MyCode Community Health Initiative participants were analyzed for ELN rare variants (mean allele frequency <1%, not currently annotated as benign). Participants with variants of interest underwent phenotyping by dual chart review using a standardized abstraction tool.
View Article and Find Full Text PDFCase Report: A male newborn with occipital horn syndrome.
F1000Res
November 2024
Neonatal Intensive Care Unit, King Fahad Medical City, Riyadh, Saudi Arabia.
Article Synopsis
- - Occipital horn syndrome (OHS) is a rare genetic disease linked to a defective ATP7A gene, affecting the copper transport system and primarily impacting musculoskeletal and connective tissues.
- - A male neonate diagnosed with OHS showed distinctive symptoms such as occipital exostosis, skin laxity at the nape, and widely opened skull sutures shortly after birth.
- - This case is significant as it stresses the need for thorough investigation of early symptoms and demonstrates the essential role of early diagnosis and collaborative care in improving outcomes for patients with OHS.
Elucidating the roles of SOD3 correlated genes and reactive oxygen species in rare human diseases using a bioinformatic-ontology approach.
PLoS One
October 2024
Personalised Medicine Centre, School of Medicine, Ulster University, C-TRIC Building, Altnagelvin Hospital, Derry, Londonderry, Northern Ireland.
Article Synopsis
- Superoxide Dismutase 3 (SOD3) helps reduce oxidative stress in the body by converting superoxide into hydrogen peroxide, which can cause biomolecular damage when not regulated.
- This research used a large dataset (GSE2109) of 2,158 cancer samples to analyze the expression of SOD3 and its correlation with other genes, leading to the identification of genes that are both positively and negatively correlated.
- From the analysis, 12 significant disorders were linked to SOD3, revealing 35 novel genes associated with conditions like Ehlers-Danlos Syndrome and Renal Tubular Dysgenesis, which may help in understanding the role of oxidative stress in these diseases.
Modified blepharoplasty combined with autologous fat transplantation into the orbital septum for the correction of dermatochalasis and sunken eyelids.
J Plast Reconstr Aesthet Surg
December 2024
Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:
Article Synopsis
- This study focuses on rejuvenating the appearance of aging Asian women by combining techniques to treat both sagging upper eyelids (dermatochalasis) and sunken eyelids. //! -
- A total of 45 patients underwent sub-brow blepharoplasty with fat grafting to improve eyelid aesthetics, with assessments showing significant improvements in both depth and volume of eyelid depressions at 3 and 6 months post-surgery. //! -
- The results indicate that traditional blepharoplasty alone is not enough for sunken eyelids, and this new technique successfully enhances overall facial rejuvenation by addressing multiple concerns at once. //!
Quantitative Assessment of New Frontiers in Dermatochalasis and Periorbital Hyperpigmentation Treatment: The Role of Cross-Linked Porcine Collagen.
Aesthetic Plast Surg
October 2024
Aesthetic Medical Center, China Medical University Hospital, No. 2, Yude Rd., North Dist., 404327, Taichung, Taiwan.
Article Synopsis
The first Japanese case of autosomal dominant cutis laxa with a frameshift mutation in exon 30 of the elastin gene complicated by small airway disease with 8 years of follow-up.
BMC Pulm Med
October 2024
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- Cutis laxa is a group of connective tissue diseases that can be inherited or acquired, leading to loose skin and potential lung complications, though the specifics of pulmonary issues are not well understood.
- A 36-year-old woman with a lifelong diagnosis of cutis laxa showed severe lung impairment and unusual pulmonary function test results, along with abnormal CT scan findings but no typical signs of emphysema.
- Genetic analysis revealed a variant in the elastin gene linked to her pulmonary issues, and over eight years, her lung function continued to decline despite stable CT images, indicating progressive small airway disease.
Article Synopsis
- A study analyzed rare variants in the elastin gene, linking them to connective tissue diseases beyond known conditions like Supravalvar Aortic Stenosis and Cutis Laxa.
- Out of 184,293 participants in the MyCode Community Health Initiative, 296 had relevant gene variants, with 41% showing symptoms such as aortic hypoplasia and arterial dilation.
- The research indicates that variations in the elastin gene are significantly associated with arterial dissection and may contribute to a broader spectrum of connective tissue disorders.
A Cross-Sectional Analysis of American Insurance Coverage of Upper and Lower Lid Blepharoplasty.
J Craniofac Surg
October 2024
Division of Plastic Surgery, University of Maryland Medical Center, Baltimore, MD.
Article Synopsis
- Dermatochalasis can obstruct vision and hinder daily activities, and blepharoplasty is a surgical option that may be viewed as cosmetic by insurance providers.
- A study analyzed 70 insurance policies on blepharoplasty, revealing that 96% provide coverage, mainly for conditions like functional visual impairment due to dermatochalasis.
- However, there are inconsistencies in insurance criteria, particularly regarding visual field loss requirements, with many companies demanding stricter standards than recommended by existing literature.
Confirming the enzymatic activity and neurodevelopmental trajectory of PYCR1 mutation in one child with autosomal-recessive cutis laxa type 2.
Mol Genet Genomics
August 2024
Department of Children's Nutrition Research Center, Affiliated Children's Hospital of Capital Institute of Pediatrics, Yabao Road, Chaoyang District, Beijing, 100020, China.
Article Synopsis
- Autosomal-recessive cutis laxa type 2 (ARCL2) is a rare genetic disorder linked to mutations in the PYCR1 gene, leading to symptoms like loose skin, distinctive facial features, and developmental delays.
- A specific mutation (c.559G > A) was found in a Chinese child with severe developmental issues, which helped to analyze the effects of this mutation on the PYCR1 protein.
- The study demonstrated that the mutation causes the PYCR1 protein to misfold and lose function, confirming its role in the disorder's symptoms and the child's neurodevelopmental challenges.
Change in Brow Position After Upper Blepharoplasty With or Without Internal Browpexy.
Ann Plast Surg
October 2024
From the Department of Plastic, Reconstructive, and Aesthetic Surgery of Dokuz Eylul University, Izmir, Turkey.
Article Synopsis
- The study investigates the effects of upper blepharoplasty on eyebrow position, focusing on cases where internal browpexy is used in conjunction with the surgery.
- A total of 48 female patients were evaluated, with one group receiving only blepharoplasty and another receiving both blepharoplasty and internal browpexy, showing differing results in brow height changes.
- Findings suggest that while blepharoplasty alone can lead to a decreased brow position, combining it with internal browpexy helps to stabilize and slightly elevate the eyebrow, improving cosmetic outcomes.
Effect of decreased expression of latent TGF-β binding proteins 4 on the pathogenesis of emphysema as an age-related disease.
Arch Gerontol Geriatr
December 2024
The Department of Geriatric Medicine, The University of Tokyo, Japan; The Department of Geriatric Medicine, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Japan.
Article Synopsis
- Research focused on the role of LTBP4 in the production of elastin fibers and its connection to emphysema and associated conditions like cutis laxa.
- The study involved silencing LTBP4 in human lung fibroblasts to observe changes in cell behavior, elastin production, inflammation, and mitochondrial function.
- Results showed that reduced LTBP4 leads to decreased elastin expression, increased cellular senescence, heightened inflammation, and mitochondrial dysfunction, suggesting LTBP4's involvement in the development of emphysema, alongside smoking and genetic factors.
Extending the Indications for Direct Transcutaneous Lower Blepharoplasty With an Infraorbital Incision to Tear Trough Deformities, Suborbicularis Oculi Fat, Festoons, and Revision Blepharoplasty.
Plast Surg (Oakv)
August 2024
Schlosspark Klinik Ludwigsburg, Privatklinik für Plastische und Ästhetische Chirurgie, Ludwigsburg, Germany.
Article Synopsis
- Treating big problems with the lower eyelids can be tough, especially with loose skin and fat pads!
- A new method called direct transcutaneous blepharoplasty uses a specific cut under the eye to fix these issues safely!
- In a study with 21 patients, everyone felt happy with their results after surgery, and the scars looked good too!
Is the Severity of Preoperative Eyelid Dermatochalasis Directly Correlated with Patient Satisfaction After Upper Blepharoplasty? A Prospective Study Based on PROMs.
Aesthetic Plast Surg
October 2024
Department of Plastic, Reconstructive and Cosmetic Surgery, Campus Bio-Medico University Hospital, Via Alvaro del Portillo 200, Rome, Italy.
Article Synopsis
- * Conducted from April 2022 to April 2023, it involved 79 patients who saw significant improvements in eyelid appearance and satisfaction, with no link found between the severity of eyelid skin issues before surgery and satisfaction afterward.
- * The results highlight the importance of using validated questionnaires like FACE-Q to assess patient experiences, indicating that even minor skin excess might benefit from treatment for better cosmetic outcomes and functional improvements.
Evaluation of eyelid features' changes before and after COVID-19 pandemic amongst healthcare and home office workers.
Int Ophthalmol
July 2024
Department of Ophthalmology, Ankara Etlik City Hospital, Ankara, Turkey.
Article Synopsis
- - The study aimed to assess how N95 mask usage during the COVID-19 pandemic impacted eyelid features among healthcare workers and compared these changes to a control group of home-office workers, using a computer vision algorithm for analysis.
- - A total of 60 healthcare workers and 40 control participants were studied using biometric photographs before and after the pandemic, focusing on measurements such as marginal reflex distances (MRD1, MRD2) and brow pupil diameter (BPD).
- - Results showed significant reductions in MRD1, PTS, and BPD values in healthcare workers after the pandemic, while control participants also experienced some decreases, indicating a broader effect that wasn't limited to mask usage.
Extreme arterial tortuosity with ascending aortic aneurysm in a child with suspected Cutis Laxa syndrome.
Acta Cardiol
July 2024
Department of Cardiovascular Radiology & Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India.
Relationship between histopathological findings of patients with dermatochalasis and vitamin D deficiency.
Int Ophthalmol
July 2024
Department of Pathology, Adıyaman University Education and Research Hospital, Adıyaman, Turkey.
Article Synopsis
- The study aimed to compare the histopathological findings of patients with dermatochalasis (DC) who underwent upper eyelid blepharoplasty (ULB) and a control group based on their serum vitamin D (SVD) levels.
- It included 136 upper eyelid skin samples from 68 DC patients and 53 control patients, measuring various factors such as lymphatic vessel count, collagen depth, and elastic fiber density.
- Results showed that DC patients had significant differences in several histopathological parameters compared to controls, with lower SVD levels associated with altered lymphatic and collagen features.
Long-read sequencing identifies an SVA_D retrotransposon insertion deep within the intron of as a novel cause of occipital horn syndrome.
J Med Genet
September 2024
Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
Article Synopsis
- - This study identifies an ancient SVA_D retrotransposon as the novel cause of occipital horn syndrome (OHS), a genetic disorder linked to copper metabolism due to ATP7A dysfunction.
- - Researchers detected a 2.8 kb insertion in the patient's gene that disrupted normal mRNA splicing, which was confirmed using long-read sequencing techniques.
- - Treatment with antisense oligonucleotides restored proper gene expression and reduced copper accumulation in patient cells, highlighting the SVA_D retrotransposon's unexpected role in rare genetic diseases.