3,442 results match your criteria: "Dermatitis Herpetiformis"
Rare Association of Dermatitis Herpetiformis and Chronic Plaque Psoriasis.
Clin Case Rep
December 2024
Dermatology and Venereology Department Ibn Rochd University Hospital, Hassan II University of Casablanca Casablanca Morocco.
Dermatologists should consider investigating for coexisting autoimmune conditions such as dermatitis herpetiformis and/or coeliac disease, in patients with psoriasis presenting clinical signs and symptoms, in order to ensure an accurate diagnosis and improve patients' long-term management.
View Article and Find Full Text PDFRisk for hospital-treated infections in dermatitis herpetiformis and coeliac disease.
Eur J Intern Med
December 2024
Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Dermatology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland.
Inflammatory Myopathies and Autoimmune Gluten-related Disorders: A Scoping Review of Pathophysiological Interconnections and Hypothesis.
Recent Adv Inflamm Allergy Drug Discov
October 2024
Department of Rheumatology, Dermatology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway.
Introduction: Anecdotal reports describe patients with concurrent idiopathic inflammatory myopathy (IIM) and celiac disease (CeD) in whom the introduction of a gluten-free diet led to dramatic improvement of myositis. We first systematically reviewed all peer-reviewed publications on concomitant IIM and duodenal biopsy-verified CeD. The collected evidence was suggestive of associations between myositis disease activity and gluten exposure in some patients with IIM-CeD.
View Article and Find Full Text PDFEvidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study.
Clin Cosmet Investig Dermatol
November 2024
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 31000, People's Republic of China.
Aim: Increasing observational studies are revealing a positive correlation between body mass index (BMI) and the risk of Immune-mediated and Inflammatory Skin Diseases (IMID), however the causal relationship is not yet definite.
Objective: The aim of the study was to conduct a two-sample Mendelian randomization (TSMR) to explore the potential causality between BMI, and IMID and biomarkers.
Methods: The summary statistics for BMI (n = 322,154), at genome-wide significant level, were derived from the Genetic Investigation of Anthropometric Traits consortium (GIANT).
The Role of Nutrition in the Pathogenesis and Treatment of Autoimmune Bullous Diseases-A Narrative Review.
Nutrients
November 2024
Department of Clinical Dietetics, Medical University of Warsaw, Erazma Ciolka 27 Street, 01-445 Warsaw, Poland.
Article Synopsis
A Comparative Study of Direct Immunofluorescence Patterns in Linear IgA Bullous Dermatosis Versus Dermatitis Herpetiformis.
Am J Dermatopathol
November 2024
Professor and Department Chair, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.
Article Synopsis
- - Dermatitis herpetiformis (DH) and linear IgA bullous dermatosis (LABD) are skin conditions identifiable by specific patterns of IgA deposition observed through direct immunofluorescence (DIF) testing, which may include other immunoglobulin deposits. - An analysis comparing 45 LABD cases to 48 DH cases revealed that the "picket fence pattern" was absent in LABD but present in nearly half of the DH cases, along with differences in the levels of IgG, IgM, and kappa light chains between the two conditions. - The "picket fence pattern" is a highly specific (100%) but not very sensitive (47.9%) indicator for diagnosing DH, potentially aiding clinicians
Skin as a Reflection of Gut Health: An Overview of Dermatological Manifestations in Primary Neoplastic and Autoimmune Gastrointestinal Disorders.
Cureus
October 2024
Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Gastrointestinal (GI) diseases can present with several extraintestinal manifestations, and cutaneous signs and symptoms are most frequent. Although conventionally GI and skin are considered two entirely separate organ systems, they are closely correlated in origin. An increasing amount of data highlights the complex relationship between GI and dermatological conditions.
View Article and Find Full Text PDFDermatitis Herpetiformis Duhring.
JMA J
October 2024
Department of Dermatology, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
Laboratory and clinical haemostatic aberrations in primary dermatologic disease: A review.
Thromb J
November 2024
Department of Dermatology, University of Nebraska Medical Center, 985645, Omaha, NE, 68198-5645, USA.
Article Synopsis
Autoimmune Diseases and Risk of Non-Hodgkin Lymphoma: A Mendelian Randomisation Study.
Cancer Med
November 2024
Yale Center for Perinatal, Pediatric, and Environmental Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
Article Synopsis
- Non-Hodgkin lymphoma (NHL) is a prevalent type of blood cancer, and its causes remain largely unknown, though autoimmune diseases are suspected as potential risk factors.
- A study used Mendelian randomization to investigate the relationship between ten autoimmune diseases and NHL risk, utilizing data from various European ancestry cohorts.
- The results indicated that genetically predicted susceptibility to type 1 diabetes and sarcoidosis may lower NHL risk, while no significant association was found for the other eight autoimmune diseases; further research is needed to confirm these findings.
Uncommon and Unusual Variants of Autoimmune Bullous Diseases.
Indian Dermatol Online J
August 2024
Department of Dermatology, Venereology and Leprology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Article Synopsis
- Autoimmune blistering diseases (AIBDs) are skin conditions caused by the body's immune system attacking certain proteins, leading to blister formation, and can be categorized into intraepidermal and subepidermal types.
- The objective of this review is to raise awareness about rare and uncommon AIBD variants, such as pemphigus herpetiformis and anti-laminin 332 pemphigoid, among others.
- By discussing these unusual variants, the review aims to assist healthcare professionals in the early diagnosis and treatment of these conditions.
Beyond the Gut: Exploring Cardiovascular Implications of Celiac Disease.
Cardiol Rev
September 2024
Department of medicine, Penn State Hershey Medical Center, PA.
Article Synopsis
- * There is an increasing link between CD and cardiovascular diseases (CVDs) like atherosclerosis and arrhythmia, attributed to factors like chronic inflammation and nutrient deficiencies.
- * The article reviews how CD may lead to different CVD outcomes, analyzing existing studies that show both positive and negative effects of CD on cardiovascular health.
Detection of autoantibodies to heat shock protein 70 in the saliva and urine of normal individuals.
Front Immunol
August 2024
Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Article Synopsis
- Cells under stress produce heat shock proteins (Hsps), with Hsp70 being found in all human cell types and fluids like blood, urine, and saliva.
- * The existence of anti-Hsp70 autoantibodies in healthy individuals' serum is known, and their levels increase with conditions like coeliac disease and dermatitis herpetiformis.
- * This study is the first to identify these autoantibodies in saliva and urine, raising questions about their role and potential as noninvasive biomarkers for autoimmune disease diagnosis and prediction, warranting further research.*
Facial Dermatitis Herpetiformis.
Skinmed
August 2024
Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA.
Article Synopsis
- A 34-year-old African-American woman with a history of HIV and hypertension visited the clinic due to recurring blisters on her face, specifically her nose and cheeks, for the past 8 months.
- The blisters appear about once a month, can be itchy, but resolve on their own without intervention.
- At her appointment, the only noticeable issue was post-inflammatory hyperpigmentation on her nose, and she had photos on her phone to illustrate the blisters' appearance.
Dapsone Use in Dermatology.
Am J Clin Dermatol
September 2024
Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.
Article Synopsis
- Dapsone was originally developed for dyeing textiles but was recognized in the 1930s for its antibacterial effects, leading to its use in treating leprosy and dermatitis herpetiformis.
- The review discusses both FDA-approved and off-label applications of dapsone in dermatology, emphasizing its effectiveness as a first-line or adjunct therapy for various skin diseases.
- Dapsone is noted for its versatile uses, safety, and cost-effectiveness, with ongoing clinical trials investigating its potential in new dermatological applications.
Celiac Disease: A Forty-Year Analysis in an Italian Referral Center.
Nutrients
July 2024
Department of Translational Medicine, St. Anna Hospital, University of Ferrara, 44124 Ferrara, Italy.
Article Synopsis
- * There was a dramatic rise in CD diagnoses post-2000, with non-classical forms being most common, and gastrointestinal symptoms like diarrhea and bloating seen in about half of the patients.
- * The study also found high rates of associated conditions, such as osteopenia in nearly 60% of patients, and suggested an evolution in disease presentation towards more subclinical and non-classical cases over time.
Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis.
Clin Immunol
August 2024
Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong, China. Electronic address:
Article Synopsis
- Linear IgA bullous dermatosis (LABD) and dermatitis herpetiformis (DH) are types of autoimmune skin disorders linked to IgA, and this study aimed to explore their causes using serum proteomics.
- Researchers analyzed 92 biomarkers in serum samples from LABD, DH patients, and healthy controls, discovering elevated levels of certain biomarkers specific to these conditions.
- The study identified distinct biomarker clusters for LABD and DH, with six specific biomarkers showing potential for better prognosis in DH patients, which could help differentiate these disease subtypes in the future.
State-of-the-art diagnosis of autoimmune blistering diseases.
Front Immunol
June 2024
Department of Dermatology, Allergology and Venerology, University of Lübeck, Lübeck, Germany.
Article Synopsis
- - Autoimmune blistering disorders (AIBDs) include various conditions such as pemphigus and pemphigoid, characterized by blisters and skin lesions that can have diverse appearances, making accurate diagnosis essential for treatment and prognosis.
- - Diagnosis typically combines clinical evaluation with the detection of specific autoantibodies, utilizing tests like enzyme-linked immunosorbent assay (ELISA) and direct immunofluorescence microscopy (IFM), which is considered the gold standard.
- - Recent advancements in molecular identification of target antigens have led to new diagnostic methods and treatment approaches, enhancing the ability to detect specific antibodies related to various AIBDs.
Eczema herpeticum in an immunocompetent man.
Diagn Microbiol Infect Dis
September 2024
Division of Nephrology, Department of Internal Medicine, Tungs' Taichung Metro Harbor Hospital, Taichung City, Taiwan, R.O.C. Electronic address:
Article Synopsis
- Eczema herpeticum is a serious skin condition caused by the herpes simplex virus, commonly affecting those with weakened immune systems or skin conditions like atopic dermatitis, leading to painful lesions and potential severe complications without proper treatment.
- A case study highlighted a young patient with ankylosing spondylitis, who improved after receiving antiviral and antibiotic treatment, despite not being on immunosuppressive therapy or having a history of related conditions.
- The rise in eczema herpeticum cases is linked to more people with compromised immune systems due to factors like increased HIV/AIDS prevalence, more immunosuppressive treatments, and a rise in atopic dermatitis cases, which can complicate diagnosis due to overlapping symptoms with other conditions like Stevens-John
A Critical Appraisal of Gluten in Skin Disorders, the Evidence So Far, and Updated Recommendations.
Indian J Dermatol
April 2024
From the Department of Dermatology, Venereology and Leprosy, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Article Synopsis
- Gluten, a protein found in cereals like wheat and barley, has been linked to various skin disorders including psoriasis and urticaria, although research on this connection is not very thorough.
- A comprehensive search of medical databases identified 1487 articles, ultimately narrowing it down to 114 relevant studies, which were reviewed to assess gluten's role in these conditions.
- While a gluten-free diet may help some chronic skin issues, it's important to note that in most cases, gluten restriction isn’t necessary and could potentially cause nutritional deficiencies.
Pemphigus Herpetiformis: A Report of an Unusual Type of Pemphigus in a Three-Year-Old Female.
Cureus
April 2024
Dermatology, As'ad Al-Hamad Dermatological Center, Kuwait City, KWT.
Article Synopsis
- - Pemphigus herpetiformis (PH) is a rare autoimmune skin condition that mostly affects adults, but it's extremely uncommon in young children, like the three-year-old girl in the case study.
- - The child exhibited skin issues resembling other conditions, and a biopsy revealed several specific features, including inflammation and blisters.
- - Treatment with clobetasol ointment and dapsone led to significant improvement in her symptoms, highlighting the need to recognize PH in pediatric cases and encouraging more research to understand it better.
Sweet Syndrome as a Herpetiform Mimic: A Diagnostic Challenge.
Am J Dermatopathol
August 2024
Pathology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Article Synopsis
- The case discusses a 26-year-old woman with a history of lupus who developed Sweet syndrome, presenting with symptoms that resembled a herpetic infection.
- The patient's symptoms included facial swelling, fever, headache, and joint pain, along with skin lesions that looked like vesicles on inflamed skin, leading to initial confusion in diagnosis.
- The diagnosis was confirmed through a skin biopsy, and treatment with corticosteroids and antibiotics successfully resolved her symptoms, emphasizing the need for doctors to consider Sweet syndrome in similar cases.
Granular C3 dermatosis-A report of two cases and a mini-review of literature.
J Dermatol
December 2024
Department of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Article Synopsis
- - Granular C3 dermatosis (GCD) presents with skin lesions similar to dermatitis herpetiformis and is characterized by the deposition of complement C3 and C5b-9 at the epidermal basement membrane zone, as seen in direct immunofluorescence tests.
- - Two cases of GCD highlighted different symptoms: a 49-year-old man with itchy blisters and a 53-year-old woman with widespread pruritic papules and blisters, both showing eosinophilia and specific histopathological features.
- - Treatment for GCD included topical steroids and oral medications for the first patient with success, while the second patient improved with oral steroids but had some lingering symptoms; overall awareness and
[The disease under chronic urticaria: beyond itching].
Rev Alerg Mex
February 2024
Servicio de Alergología, Hospital Punta Europa, Algeciras-Cádiz-España.
Article Synopsis
- The case describes a 53-year-old woman with a history of skin rashes that were initially thought to be urticaria but were later diagnosed as dermatitis herpetiformis after various tests and treatments failed to provide relief.
- The patient had an existing condition of diffuse large B cell lymphoma in remission and experienced herpetiform lesions since 2010, which led to further investigation including a skin biopsy and antibody testing.
- The conclusion emphasizes the need for careful diagnosis in chronic urticaria cases that don’t respond to standard treatments, highlighting the importance of a multidisciplinary approach and continuous patient monitoring due to potential side effects of prescribed treatments like dapsone.