Efficacy and safety of different hyaluronic acid fillers on cheek volume augmentation: systematic review and network meta-analysis.

Background: Various rejuvenation surgeries, including hyaluronic acid (HA) fillers, aim to address mid-face volume loss. However, literature on the comparative efficacy and safety of different HA fillers for the zygomatic area remains limited.

Methods: This systematic review and network meta-analysis (NMA), adhering to NMA PRISMA 2020 and Cochrane guidelines.

Long-Term Performance and Safety of a Superficial HA Filler With Tri-Hyal Technology on Different Facial Zones: Forehead, Cheeks, Crow's Feet, and Upper Lips.

Background: The function of injectable hyaluronic acid-based fillers is to smooth dermal wrinkles formed during aging. The aim of this study is to evaluate the performance and safety of a dermal filler after its commercialization.

Methods: In this context, an 18-month prospective randomized single-blind study for the efficacy and safety of ART FILLER Fine Lines (AFFL) was performed on the forehead, the upper lip, the cheek folds, and the crow's feet.

Adipose Tissue, Regeneration, and Skin Health: The Next Regenerative Frontier.

Adipose tissue, or fat compartments, has long been considered a storage depot and an energy source. However, a large part of new research, starting with the discovery of adipose-derived stem cells, has redirected this thinking toward the tremendous regenerative capacity that adipose tissue possesses when it is healthy. This has resulted in multiple technologies being explored with fat as a basis or with fat as a target aiming at the stimulation of new small hyperplastic adipose cells exuding adipokines and encouraging the proliferation of a whole host of progenitor cells that can have positive effects on many organ systems.

A Pilot One and Two-Year Prospective, Blinded Clinical Evaluation of Efficacy, and Safety of Combined Treatment With Crosslinked Hyaluronic Acid Dermal Filler and Barbed Polydioxanone Suspension Threads for Mid-Face Contour Enhancement.

Introduction: The combination of hyaluronic acid (HA) fillers and polydioxanone (PDO) thread lifting is gaining popularity for mid-face rejuvenation, especially among the Asian population. Despite the common use of these techniques, there is a paucity of long-term studies assessing their combined efficacy and safety. This study aims to evaluate the efficacy and safety of combined HA filler and PDO thread treatment for mid-face rejuvenation over a 24-month period in a Korean population.

Investigating the Relationship Between the Emulsification Parameters and Physical-Chemical Properties of Poly(D,L-lactic acid) Particles for Dermal Fillers.

Poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid) (PDLLA) particles have been applied as dermal fillers for soft-tissue augmentation because they can induce foreign-body reactions, resulting in fibroblast proliferation and collagen formation. Although PLLA and PDLLA fillers are safe and biocompatible, clinical complications such as nodules and granulomas have been reported, possibly due to incomplete reconstitution. PDLLA particles were prepared via emulsification in this study, and three stirring speeds were investigated when adding PDLLA into carboxymethyl cellulose solution.

Analysis of Hospitalization Cases for Filler Injection Complications: A Five-Year Retrospective Study Among Iranian People.

Introduction: The skin is the largest organ system with many important clinical functions. Due to the increase in demand for cosmetic procedures and consequently the increase in complications from filler injections, this research aims to review the hospitalization cases involving filler complications.

Methodology: This study retrospectively and cross-sectionally reviews patient records hospitalized between the years 2016 to 2020, focusing on demographics (age, gender, residence), type of filler, type of complications, onset and duration of complications, duration of hospital stay, the person who administered the injection, and treatment outcomes.

Nonsurgical Medical Aesthetics and Patient Quality of Life: An Umbrella Review.

Nonsurgical cosmetic facial procedures have become popular treatment options for individuals seeking aesthetic improvements. Despite a breadth of literature on patient satisfaction with treatment outcomes, there is a lack of information specific to changes in quality of life outcomes. The objective of this umbrella review is to report the effectiveness of nonsurgical facial aesthetic treatments on reported quality of life in cosmetic treatment-seeking patients.

An Open Source Framework for Free Precise Digital Facial Analysis.

In the dynamic landscape of digital healthcare and facial aesthetics, there is a rising demand for tools combining precision and accessibility. This article explores an innovative approach emphasizing accuracy and accessibility in facial aesthetic procedures through individualized planning and open-source software utilization. Digital facial analysis was conducted using facial photogrammetry capturing 16 simultaneous images in 0.

Engineered collagen/PLLA composite fillers to induce rapid and long-term collagen regeneration.

Injectable subcutaneous fillers are used in medical aesthetics primarily to correct skin wrinkles. The limitations of collagen fillers include rapid degradation, lack of collagen regeneration effects and high-frequency injections. The regenerative filler of Sculptra (Aesthetic) offers prolonged regenerative effects; however, the slow collagen regeneration results in prolonged waiting time for the filling effects.

Innovative Approach to Minimize Serious Complications in Cosmetic Dermal Filling.

Cosmetic dermal filling represents a significant advance in aesthetic medicine, providing non-invasive treatments with immediate and durable outcomes. Despite the generally safe nature of dermal fillers and avoidable complications with proper technique and planning, they are still risky, with potential complications varying from mild and transient to severe and enduring. This study introduces innovative strategies designed to decrease the risk of serious complications, such as vascular occlusion.

Ophthalmic complications of injectable facial fillers.

The recently published mini-review article by Miotti is an effort to clarify various aspects regarding the choice between fat grafts and fillers in facial aesthetic surgery. One of the complications associated with the administration of fillers is the possibility of vascular injury and spread of the dermal filler into the orbit, causing unexpected effects at a site distant from that of the initial injection, including ophthalmoplegia, ptosis and even visual compromise. Acute vision loss following filler injection is a devastating complication, occurring in up to 0.

Spontaneous and induced degradation of dermal fillers: A review.

Dermal fillers are among the most versatile tools in esthetic medicine. A broad range of temporary, semipermanent, and permanent filler products are on the market. We performed a narrative review on spontaneous and induced degradation of dermal fillers and .

The Role of GLP-1 Agonists in Esthetic Medicine: Exploring the Impact of Semaglutide on Body Contouring and Skin Health.

Introduction: Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, have revolutionized the treatment of diabetes and obesity by promoting significant weight loss through incretin effects. However, rapid weight reduction induced by these medications often leads to esthetic challenges, including facial volume loss, skin laxity, and body contour irregularities. This commentary reviews the esthetic consequences of GLP-1-induced weight loss and explores solutions for managing these concerns in clinical practice.

[The impact of diabetes on aesthetic procedures].

Diabetes may have an impact on aesthetic medicine, influencing both the safety and efficacy of various aesthetic procedures. Key aspects of the impact of diabetes on aesthetic medicine are summarized. Individuals with diabetes often experience dry skin, a condition known as xerosis, which may affect the overall texture and appearance of the skin.

Adverse effects of the aesthetic use of botulinum toxin and dermal fillers on the face: a narrative review.

Objective: To evaluate the adverse effects of facial aesthetic treatments using botulinum toxin and biomaterial implants.

Methods: The bibliographic research for this narrative review considered articles published in journals from the Medline, Pubmed, Embase and Lilacs databases with the following terms: "dermal fillers AND complications, vascular complications AND dermal fillers, adverse reaction, AND toxin botulinum and adverse reaction AND dermal fillers". Inclusion criteria were articles available in English on adverse events with the aesthetic use of botulinum toxin and dermal fillers/biostimulators.

Histologic Effects of Fractional Lasers and Energy-Based Devices on Intradermally Injected Hyaluronic Acid Filler for Improving Skin Smoothness.

Background: Prior studies have shown that energy-based devices (EBDs) over pre-injected hyaluronic acid (HA) fillers do not significantly affect clinical outcomes. However, the impact of EBDs over newly FDA-approved HA filler for improving skin smoothness is still undetermined.

Objective: To evaluate the immediate histologic changes after various popular EBDs are performed over pre-injected, newly FDA-approved intradermal HA filler.

Comparison of Different Types of Poly-L-Lactic Acid Microspheres In Vitro and In Vivo Studies.

Background: Biodegradable polymers are commonly used as dermal fillers in plastic surgery. Among these, poly-L-lactic acid (PLLA) distinguishes itself owing to its good biocompatibility, degradability, and ability to act as a collagen stimulator.

Objectives: In this study, the differential behavior of PLLA microspheres with varying microscopic morphology and surface hydrophilicity was investigated both in vitro and in vivo.

Utilization of Injectable and Device-Based Treatments in Medical Dermatology: A Survey on Demographics, Conditions, and Resident Involvement.

Background: Injectable and device-based treatments are used for medical dermatologic conditions, but understanding dermatologists' practices remains limited.

Objective: This study examines injectable and device-based treatments for medical dermatologic conditions to identify patterns and potential improvements.

Materials And Methods: A survey was distributed to Association of Academic Cosmetic Dermatology members, covering practice settings, conditions treated, pricing, and resident involvement.

A Review of the Role and Treatment of Biofilms in Skin Disorders.

A biofilm is a diverse community of microorganisms enclosed in an extracellular matrix. Although this organization of cells exists naturally in healthy skin, it is also involved in the pathogenesis of multiple skin disorders, such as acne and atopic dermatitis. Because biofilms provide microorganisms with a survival advantage and increased resistance to traditional antibiotics, they can be very difficult to treat, particularly when the goal is to also preserve the natural skin microbiota.

Dermal Filler-Induced Alopecia: A Case Report and Literature Review.

Background: Dermal filler-induced alopecia is a rare yet significant complication of aesthetic procedures primarily associated with vascular occlusion and subsequent tissue ischemia. Hyaluronic acid (HA) fillers, though widely used for facial rejuvenation, can lead to adverse outcomes such as skin necrosis and hair loss, particularly in high-risk areas like the temples and glabella.

Objective: This case report aims to highlight the clinical presentation, diagnostic approach, and multidisciplinary management of filler-induced alopecia, contributing to the existing literature with a comprehensive review of previously reported cases.

Treatment of Mid-Face Aging with Calcium Hydroxylapatite: Focus on Retaining Ligament Support.

The mid-face has been rendered as the cornerstone of facial aesthetic improvement, since treating the mid-face has also beneficial effects on neighboring esthetic units and therefore should be one of the first areas to be assessed. Retaining ligaments (RL) bind soft tissue layers of the face to the underlying facial skeleton. It remains controversial whether RL suffers laxity with aging or if changes in 42 bone and other structures where ligaments are inserted lead to altered mechanical function of the latter.

Comprehensive assessment of intradermal responses to hyaluronic acid-based skin injection fillers through multi-pathway dynamic synergies.

Skin injection filling products must undergo a rigorous evaluation before entering the market, and intradermal reactions are crucial for biocompatibility. However, current evaluation methods for skin injection fillers often lack precision. This study aims to explore a comprehensive evaluation method by incorporating additional indicators: dermoscopy, transepidermal water loss, moisture content, ultrasound, and histological observation.

Case reports on hand prejuvenation: clinical outcomes in middle-aged women with hyaluronic acid filler plus lidocaine.

Background: Hand rejuvenation with hyaluronic acid filler injections is gaining more attention for its ability to correct volume loss and improve skin quality. The hand dorsum is prone to loss of dermal elasticity and subcutaneous atrophy as individuals age, and administering hyaluronic acid fillers has become an option to restore the smoothness and youthful contour of the hand.

Objective: The aim of this study is to demonstrate that injections with Definisse Touch Filler Plus Lidocaine are effective and safe for hand rejuvenation.