12 results match your criteria: "Deptartment of Biomedicine and Prevention; University of Rome "Tor Vergata"; Rome[Affiliation]"
Levels and trends of metals in human populations living in the Arctic.
Int J Circumpolar Health
December 2024
Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
The 2021 Arctic Monitoring Assessment Program (AMAP)'s Human Health Assessment report presents a summary of the presence of contaminants in human populations across the circumpolar Arctic and provides an update to the previous assessment released in 2015. The primary objective of this paper is to summarise some of these findings by describing the current levels of metals across the Arctic, including key regional and temporal trends based on available national data and literature, and highlight knowledge gaps. Many Arctic populations continue to have elevated levels of these contaminants, and the highest levels of mercury (Hg) were observed in populations from Greenland, Faroe Islands, and Nunavik (Canada).
View Article and Find Full Text PDFImproved outcome of COVID-19 over time in patients treated with CAR T-cell therapy: Update of the European COVID-19 multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party (IDWP) and the European Hematology Association (EHA) Lymphoma Group.
Leukemia
September 2024
Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Department of Laboratory Medicine, Karolinska Institutet and University Hospital, Karolinska Comprehensive Cancer Center, Karolinska ATMP Center, Stockholm, Sweden.
Article Synopsis
- - The study assessed COVID-19 mortality rates among patients receiving Chimeric Antigen Receptor (CAR) T-cell therapy for blood cancers, comparing outcomes across three years (2020, 2021, 2022) during the Omicron period.
- - There was a significant decline in COVID-19-related mortality: from 43.6% in 2020 to 7.5% in 2022, indicating improvement over time, with year of infection identified as a key predictor of survival.
- - Although mortality decreased, CAR T-cell recipients still face a higher risk of complications compared to the general population, highlighting the need for ongoing monitoring and preventive measures during their treatment.
First Expert Elicitation of Knowledge on Possible Drivers of Observed Increasing Human Cases of Tick-Borne Encephalitis in Europe.
Viruses
March 2023
UK Centre for Ecology & Hydrology, Benson Lane, Crowmarsh Gifford, Oxfordshire OX10 8BB, UK.
Article Synopsis
- * Researchers conducted a study involving 40 European experts to identify and evaluate 59 potential drivers of TBE's emergence and rising incidence, categorizing them into eight domains.
- * The top drivers identified include changes in human behavior, eating habits, landscape alterations, environmental factors like humidity and temperature, and the presence of various tick species and wildlife reservoirs.
Background: More than 3 billion people do not have access to clean energy and primarily use solid fuels to cook. Use of solid fuels generates household air pollution, which was associated with more than 2 million deaths in 2019. Although local patterns in cooking vary systematically, subnational trends in use of solid fuels have yet to be comprehensively analysed.
View Article and Find Full Text PDFGenetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.
Nat Commun
September 2022
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
Article Synopsis
- The QT interval is a key measure in electrocardiograms that indicates the timing of heart muscle contractions and recoveries; abnormalities can lead to serious heart conditions.
- A study involving over 250,000 individuals identified many genetic loci linked to various heart rhythm measures, revealing important genetic factors associated with QT, JT, and QRS intervals.
- The findings suggest that certain gene variations could inform new treatments for arrhythmias and highlight genetic pathways involved in heart function and energy metabolism.
The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic.
J Affect Disord
February 2022
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; The Zucker Hillside Hospital, Northwell Health, New York, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA. Electronic address:
Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed.
Methods: .
Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A).
J Affect Disord
February 2022
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; The Zucker Hillside Hospital, Northwell Health, New York, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA. Electronic address:
Background: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable children and adolescents is crucial.
Methods: The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT - www.
Prognostic Impact and Risk Factors of Infections in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib.
Cancers (Basel)
June 2021
Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, 35121 Padua, Italy.
Ibrutinib represents extraordinary progress in the treatment of chronic lymphocytic leukemia (CLL). However, treatment-related adverse events limit the benefit of this agent. This observational, multicenter study focused on the incidence, risk factors, and prognostic impact of infections in 494 patients with CLL treated with an ibrutinib-based treatment.
View Article and Find Full Text PDFPatients with acute myeloid leukemia (AML) harboring FLT3 internal tandem duplications (ITDs) have poor outcomes, in particular AML with a high (≥0.5) mutant/wild-type allelic ratio (AR). The 2017 European LeukemiaNet (ELN) recommendations defined 4 distinct FLT3-ITD genotypes based on the ITD AR and the NPM1 mutational status.
View Article and Find Full Text PDFContribution of Health Researches in National Knowledge Production: A Scientometrics Study on 15-Year Research Products of Iran.
Int J Prev Med
April 2017
Dentofacial Deformities Research Center, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Researchers, practitioners, and policymakers call for updated valid evidence to monitor, prevent, and control of alarming trends of health problems. To respond to these needs, health researches provide the vast multidisciplinary scientific fields. We quantify the national trends of health research outputs and its contribution in total science products.
View Article and Find Full Text PDFPostprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation.
Nat Immunol
March 2017
Clinic of Endocrinology, Diabetes and Metabolism University Hospital Basel, Basel, Switzerland, and Department of Biomedicine, University of Basel, Basel, Switzerland.
Article Synopsis
- Chronic activation of the IL-1β system negatively affects type 2 diabetes and other metabolic diseases, but its potential positive role in glucose metabolism has been largely overlooked.
- Feeding triggers an increase in macrophages secreting IL-1β in a glucose-dependent way, which then aids in stimulating insulin secretion after eating.
- IL-1β works alongside insulin to enhance glucose uptake in macrophages and contributes to a pro-inflammatory response, indicating that this cytokine plays a key role in linking metabolism and immune responses.
Several cellular microRNAs show substantial changes in expression during HIV-1 infection and their active role in the viral life cycle is progressively emerging. In the present study, we found that HIV-1 infection of Jurkat T cells significantly induces the expression of miR-222. We show that this induction depends on HIV-1 Tat protein, which is able to increase the transcriptional activity of NFkB on miR-222 promoter.
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