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Article Synopsis
- Intervertebral disc degeneration is a major contributor to low back pain and necessitates effective preclinical research models to improve treatments.
- Both in vivo animal models and ex vivo organ culture models are commonly used, but each has its own strengths and weaknesses, leading to ongoing debates among researchers.
- Experts, through a literature review, emphasize that using a combination of various models may yield the best research outcomes by capitalizing on the unique benefits of each approach.