The impact of pharmacist-led education and prospective audit and feedback on antibiotic dose optimization within medical intensive care units in Thailand: a retrospective study.

Background: Critical illness can affect antimicrobial pharmacokinetics and pharmacodynamics. Antimicrobial stewardship programs promote appropriate antimicrobial usage. This study aimed to compare the appropriateness of antibiotic dosing, therapeutic drug monitoring, and ICU mortality before and after antimicrobial stewardship program implementation in medical intensive care units.

Pharmacy workforce: a systematic review of key drivers of pharmacists' satisfaction and retention.

Background: Pharmacy workforces are central to healthcare systems, yet the profession faces challenges in job satisfaction and retention due to evolving roles, workload pressures, and other issues. Understanding workforce stability is crucial for optimising pharmacy services.

Objective: This systematic review aimed to identify and analyze the critical factors impacting pharmacy staff job satisfaction and retention, providing actionable insights to improve workforce stability and long-term engagement in the profession.

Impact of the national health insurance coverage policy on mecapegfilgrastim utilization for chemoradiotherapy-induced neutropenia in cancer patients in China: a retrospective real-world analysis.

Objective: This study aimed to evaluate mecapegfilgrastim utilization for the prophylaxis of chemotherapy-induced neutropenia in cancer patients and to assess changes caused by the National Health Insurance Coverage (NHIC) policy.

Methods: Individual patient data, including demographics, medical insurance status, cancer type, and tumor stage, were extracted from electronic medical records in an oncology specialty tertiary hospital in Jiangsu Province, China. An interrupted time series (ITS) analysis with a segmented regression model was applied to evaluate the NHIC policy's effects, and multivariate binary logistic regression analysis was used to identify key factors influencing mecapegfilgrastim utilization.

Epileptic Encephalopathy Mutation Displays a Loss-of-Function Phenotype and Distinct Insensitivity to Valproate.

Voltage-gated sodium channels are the main targets of antiepileptic drugs, such as sodium valproate (VPA). Single nucleotide polymorphisms (SNPs) in the Nav1.6 isoform () have been reported to be closely associated with motor dysfunction in pediatric akathisia epileptica.

Chronotherapeutic considerations of benzodiazepine administration for agitation management in the emergency department.

Objective: Agitation in the emergency department (ED) affects up to 2.6% of encounters, posing significant risks to patients and caregivers. This review investigates the impact of circadian rhythms on benzodiazepine (BZD) pharmacokinetics and pharmacodynamics, focusing on how dosing time influences outcomes in managing acute agitation.

The Risk of Propofol Infusion Syndrome on Epilepsy Patients :Insights from FAERS Data and Published Case Reports.

Objective: PRIS has been documented in epilepsy patients treated with propofol. But the clinical features associated with the occurrence of PRIS in patients with epilepsy remain incompletely elucidated. This study aimed to investigate the relationship between epilepsy, antiepileptic drugs, and PRIS and draw conclusions about its clinical features.

Pharmacy students' motivations, satisfaction, and future career plans: A cross-sectional study exploring gender differences.

Background: The pharmacy profession has significantly changed over the years. Pharmacy students' perceptions of their coursework and future career aspirations may vary in relation to gender.

Objectives: The present study explored the motivations of pharmacy students to enter pharmacy school, their satisfaction with the academic program, future plans after graduation, and perceptions about the pharmacy profession in relation to gender.

Factors associated with relief from acute pain among patients admitted in medical ward of Mbarara Regional Referral Hospital, south western Uganda: A cross-sectional study.

Acute pain is an understudied subject among patients admitted in medical wards, especially in sub-Saharan Africa. Given that it is one of the commonest causes of hospital admissions, it is necessary to diagnose and adequately treat it in time. Unrelieved acute pain may have negative consequences such as; reduced quality of life, prolonged hospital stays and increased cost of treatment.

A screen to identify antifungal antagonists reveals a variety of pharmacotherapies induce echinocandin tolerance in .

Through screening a comprehensive collection of drugs approved for human use, we identified over 20 that oppose the antifungal activity of the echinocandins upon the infectious yeast, . More detailed evaluation of five such drugs, including the atypical antipsychotic aripiprazole and the tyrosine kinase inhibitor ponatinib, indicated they promote survival following exposure to the echinocandin antifungals. The activity of the five selected antagonists was dependent upon the Mkc1p MAPK pathway, however, ponatinib was paradoxically shown to suppress phosphorylation and therefore activation of Mkc1p itself.

Perceived benefits, information, vaccination history, and conspiracy beliefs as significant determinants of RSV vaccine acceptance among Arab seniors.

Background: Respiratory syncytial virus (RSV) poses a significant respiratory health risk to senior citizens, contributing substantially to hospitalizations and mortality. With the recent approval of three RSV vaccines for the elderly, it is critical to understand the factors that can shape the RSV vaccination attitudes to inform public health strategies that can enhance uptake among this vulnerable population.

Objectives: This study aimed to investigate the potential factors that could influence the attitudes toward RSV vaccination among senior citizens in Arab countries.

Improving Vaccination Coverage Through Community Pharmacy Service Delivery in Nigeria: The COVID-19 Experience and Implications for Policy Review.

Background: Globally, the use of community pharmacies and pharmacists in the delivery of vaccination services has been hampered by several factors, laws, and regulations that do not support pharmacists to participate in the delivery of vaccination services. With the advent of COVID-19 pandemic, many countries have included community pharmacists and pharmacies in vaccination services to improve coverage. This study described the delivery of vaccination services in community pharmacies using the COVID-19 experience and how their involvement impacted vaccination coverage in Nigeria.

Benzbromarone Analog SAR: Potent hURAT1 (SLC22A12) Inhibitors and Drug Transporter Interaction Studies.

Purpose: There were two main purposes for this study. One, to report two benzbromarone analogs and test their in vitro activity in the URAT1 inhibition assay; and two, to probe the structure-activity relationship (SAR) of various benzbromarone analogs regarding other drug transporters that may play a role in the uric acid uptake/elimination interplay.

Methods: In brief, chemical synthesis of two benzbromarone analogs was prepared using methods analogous to those reported.

Towards eco-friendly pharmaceuticals: Regulatory and policy approaches for sustainable medicines use.

Objectives: The current study aimed to investigate how regulatory frameworks and policies are used to support the use of sustainable medicines within the pharmaceutical sector.

Methods: The Scopus database was searched to retrieve papers. Advanced search tool of the Scopus online database was used focused on the papers that have the search query included in their titles.

Cost-effectiveness and budget impact analysis of rivaroxaban with or without aspirin compared to aspirin alone in patients with coronary and peripheral artery diseases in Iran.

Background: Low-dose aspirin and rivaroxaban are the cornerstone treatment for cardiovascular prevention in patients with peripheral artery disease (PAD) and/or stable coronary artery disease (SCAD). The combination of rivaroxaban with aspirin imposes a synergistic effect on the inhibition of factor-induced platelet aggregation. The present work aimed at comparing the cost-utility and cost-effectiveness of rivaroxaban (2.

Febuxostat, a Urate-Lowering Drug Bridging From Adults to Pediatrics; A Brief Report.

Purpose: Febuxostat, a nonpurine selective inhibitor of xanthine oxidase has elucidated an effective urate-lowering in adults. However, data on febuxostat utility in children is limited. The present study summarizes the current knowledge on the efficacy and safety of febuxostat in children with hyperuricemia.

[Essential Components of Pharmacist-Prepared Home Care Reports to Facilitate Information Sharing from the Pharmacy Pharmacist to Other Professionals].

In this study, we assessed the information sharing practices between pharmacists and multidisciplinary healthcare professionals such as doctors, care managers, and nurses, and others. We evaluated the effectiveness of "home medical care management guidance reports" and "home-visit drug management guidance reports" prepared by pharmacists. We also identified factors that could enhance collaborative practices.

Community pharmacists' pneumococcal vaccine knowledge and perceived barriers to vaccination.

Background/objective: Pneumococcal disease is a serious bacterial infection, particularly for high-risk groups such as infants, adults 65 and older, and individuals with certain conditions; however, vaccination rates remain low. Pharmacists are often visited more frequently than primary care physicians and therefore are in a unique position to increase pneumococcal vaccination rates. This study aims to identify barriers to pneumococcal vaccination and assess pharmacists' knowledge of pneumococcal vaccines in a community pharmacy setting.

Nanoemulgel mediated enhanced skin curcumin penetration/retention for local treatment of cutaneous leishmaniasis: and assessment.

Background: Skin delivery of a therapeutically effective drug is imperative for local cutaneous leishmaniasis (CL) treatment.

Objective: This study aimed to formulate, optimize, and characterize curcumin-loaded nanoemulgel for enhanced skin drug retention to treat CL locally.

Methods: Nanoemulsions were prepared by high-speed homogenization, characterized, and optimized for size, PDI, zeta potential, stability, morphology, drug contents, encapsulation efficiency, drug release, antileishmanial activity, and cell viability.

Impact of COVID-19 pandemic on the prescribing pattern of oral anticoagulants in the English primary care setting: a population-based segmented interrupted time series analysis of over 53 million individuals.

Background: The COVID-19 pandemic disrupted healthcare delivery, impacting oral anticoagulants (OAC) prescribing due to increased thromboembolic risks, Vaccine-induced immune thrombotic thrombocytopenia, and guidelines favoring Direct Oral Anticoagulants (DOACs) over warfarin. Previous studies were limited to short-term analyses.

Research Design And Methods: A segmented interrupted time series analysis was conducted using the English primary care Prescription Cost Analysis data from March/2018-March/2024 to assess the impact of the first and second COVID-19 lockdowns in March and November 2020, respectively.

In silico and evaluation of erucic acid against pentylenetetrazole-induced seizures in mice by modulating oxidative stress, neurotransmitters and neuroinflammation markers.

Background: Pentylenetetrazole (PTZ) is a commonly used chemical to induce epileptic seizures in experimental animals.

Aim: To investigate the neuroprotective effects of erucic acid against PTZ-induced seizures in mice and explore its underlying mechanisms.

Methodology: The mice were randomly allocated into four groups: normal control, PTZ-treated (35 mg/kg via intraperitoneal injection), and PTZ + erucic acid (at doses of 10 and 20 mg/kg).

Effect of perioperative individualized nutrition intervention on pancreatic surgery outcomes: a prospective single-center study.

Background: There is currently a lack of reports on prospective randomized controlled trials (RCTs) focused on personalized nutritional support in pancreatic surgery. This study aimed to evaluate the impact of perioperative individualized nutritional intervention on the outcomes of patients undergoing pancreatic surgery within the framework of enhanced recovery after surgery (ERAS).

Methods: This prospective cohort study enrolled 96 patients, randomly divided into a trial group and a control group in a 1:1 ratio.

Age diversity among older surgically treated patients with lumbar spinal stenosis: a retrospective comparative study of early and late older adults.

Background: At present, the threshold defining older adults is 65 years, and this classification has been widely accepted globally. However, with the extension of both life expectancy and healthy life expectancy, there is a need to reconsider this age-based definition. This study compared the characteristics and surgical outcomes of older patients with lumbar spinal stenosis (LSS) between the early and late stages to clarify age diversity in this population.

Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.

The aim of this study was to evaluate the effects of pleuran (β-glucan isolated from Pleurotus ostreatus) on asthma control and respiratory morbidity in children on conventional GINA-based asthma treatment who had partially controlled perennial asthma. A double-blind, placebo-controlled multicentre clinical trial with a 2-arm, parallel design was conducted across three countries; 230 children aged 7 to 17 years were randomised (1:1) into an active group (receiving a pleuran/vitamin C combination) or a placebo group (receiving vitamin C only). This study consisted of 24 weeks of treatment (2 capsules a day) and then 24 weeks of follow-up.

Receipt of Medicare Part D comprehensive medication reviews in older adults with dementia.

Background: Older adults with Alzheimer disease and related dementias (ADRDs) are at high risk for medication-related problems. Comprehensive medication reviews (CMRs), required in Medicare Part D medication therapy management (MTM) programs, aim to optimize medication use and reduce adverse events. Individual factors related to MTM eligibility and CMR receipt among beneficiaries with ADRD are unknown.