Squamous Cell Carcinoma of Rectum: How to Treat?

Squamous cell carcinoma (SCC) of rectum is an uncommonly seen malignancy. It has been difficult to establish the precise etio-pathogenesis due to paucity of cases. For the same reason, the rigorous treatment protocol has not been defined.

Multiple Bony Metastatic Lesions and Evaluation of Primary: Case Records of a Cancer Research Centre.

During 2012-13, we diagnosed 4 patients with extensive skeletal tuberculosis (TB) who were referred to us as cases of bony metastasis with unknown primary. Radiological investigations done outside favoured a diagnosis of disseminated malignancy. Positron emission tomography/computed tomography (PET/CT) scan performed in our institute for localization of primary lesion also suggested metastatic disease.

Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues.

Allogeneic hematopoietic stem cell transplantation (HSCT) remains a curative option for children with high risk and advanced acute leukemia. Yet availability of matched family donor limits its use and although matched unrelated donor or mismatched umbilical cord blood (UCB) are viable options, they fail to meet the global need. Haploidentical family donor is almost universally available and is emerging as the alternate donor of choice in adult patients.

Male Breast Cancer in India: Series from a Cancer Research Centre.

Male breast cancer (MBC) is an uncommon malignancy. The scarcity of cases has reduced the focus of research in this area as compared with female breast cancer. The incidence of breast cancer in males is slowly rising and it becomes important to study the biology of this uncommon illness.

Negative Appendectomy: an Audit of Resident-Performed Surgery. How Can Its Incidence Be Minimized?

Negative appendectomy remains a concern in current surgical practice. Data from the developing world is scarce. Data of appendectomies during the last 5 years were analyzed.

Calot's Triangle: Proposal to Rename it as Calot's Region and the Concept of 'Ducto-Arterial Plane'.

The anatomical description of the area requiring dissection during cholecystectomy is incomplete and incorrect. We carefully observed the anatomy of this region for over 20 years in various biliary pathologies and present our view. Describing this area in the form of triangles is incorrect.

Hemophagocytic syndrome following haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide.

Hemophagocytic syndrome (HPS) is a rare but serious complication after allogeneic transplantation which has been reported to be particularly high after unrelated cord blood transplantation. We report on the incidence, risk factors and outcome of HPS in 51 patients (age 2-64 years) after haploidentical peripheral blood stem cell (PBSC) transplantation with post-transplantation cyclophosphamide (PTCY). The incidence of HPS was 12.

Adenocarcinoma of Cervical Esophagus Arising in the Barrett's Mucosa.

Carcinoma of esophagus encompasses mainly two different histopathologic subtypes, squamous cell carcinoma and adenocarcinoma. Adenocarcinoma is the most common cancer seen. It usually arises in association with Barrett's esophagus and is localised in the distal third of the esophagus while squamous cell carcinoma predominates in the middle third.

Analyzing the performance of the planning system by use of AAPM TG 119 test cases.

Our objective in this study was to create AAPM TG 119 test plans for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in the Monaco planning system. The results were compared with the published studies, and the performance of the Monaco planning system was analyzed. AAPM TG 119 proposed a set of test cases called multi-target, mock prostate, mock head and neck and C-shape to ascertain the overall accuracy of IMRT planning, measurement, and analysis.

Rash: annoying but prognostic.

Targeted therapies are commonly utilised in modern oncology practice. Skin toxicity is a frequently encountered problem associated with them. Some of the skin toxicites carry prognostic significance and it is important to identify them.

"Difficult to flush chemoport: an important clinical sign".

A central venous access device is an intravenous device whose internal tip lies in a large central vein. Chemoport is a central venous device which serves various purposes in oncology practice apart from optimum delivery of chemotherapy. Various early and late complications have been frequently reported with the use of these devices.

"Peripherally inserted central catheters: our experience from a cancer research centre".

Peripherally inserted central catheter (PICC) is a modern drug delivery system utilised in oncology practice. The purpose of this study was to determine the complications associated with PICCs within a one year study period. PICCs inserted in patients registered at Dharamshila Cancer Hospital and research centre from 1st July 2012 to 30th June 2013 were studied.

Assessment of knowledge of harmful effects and exposure to recreational music in college students of delhi: a cross sectional exploratory study.

Exposure to loud sounds results in a mild to profound degree of temporary or permanent hearing loss. Though occupational noise exposure remains the most commonly identified cause of noise-induced hearing loss, potentially hazardous noise can be encountered during recreational activities. Unfortunately not much attention is being given to the increasing trend of prolonged exposure to noisy environment, in the younger generation of Indians.

Comparative analysis of volumetric-modulated arc therapy and intensity-modulated radiotherapy for base of tongue cancer.

The aim of this study was to compare the various dosimetric parameters of dynamic multileaf collimator (MLC) intensity modulated radiation therapy (IMRT) plans with volumetric modulated arc therapy (VMAT) plans for base of tongue cases. All plans were done in Monaco planning system for Elekta synergy linear accelerator with 80 MLC. IMRT plans were planned with nine stationary beams, and VMAT plans were done for 360° arc with single arc or dual arc.

Assessment of olfaction using the "i-smell" test in an Indian population: a pilot study.

The objective of our study was to assess the olfactory function in patients having sinonasal disease and in normal healthy individuals and to establish a clinical test for olfaction in Indian population. Odor threshold and odor identification testing in patients of sinonasal disease and in subjects with no sinonasal disease was done in an academic tertiary medical center. Fifty patients with sinonasal disease (Group A) and 100 normal subjects with no complaints of olfactory dysfunction (Group B) were prospectively recruited.

Interventional sialendoscopy for parotid ductal calculi: our preliminary experience.

With this article we present our initial experience with interventional sialendoscopy of the parotid duct for the parotid calculi. We carried out a prospective study of patients of parotid calculi in a tertiary referral centre. Diagnostic and interventional sialendoscopy was performed in five cases of parotid calculi.

Transient evoked and distortion product otoacoustic emission profile in patients of otosclerosis: a preliminary report.

The aim of this study was to investigate the profile of transient evoked and distortion product otoacoustic emissions in patients of otosclerosis and to assess any change in otoacoustic emission profile after surgical intervention. This prospective study under tertiary referral centre setting included 31 patients suffering from otosclerosis, who underwent surgical intervention in the form of stapedotomy. Air-bone gap on pure tone audiometry, pre-operative profile and postoperative profile of transient evoked and distortion product otoacoustic emissions at 1 month and 3 months were the main outcome measures of the subjects.

Tumor lysis syndrome developing intraoperatively.

Tumor lysis syndrome is a potentially life threatening condition which is most commonly encountered in patients being treated with chemotherapy. We report a case of spontaneous tumor lysis syndrome that developed intraoperatively in a patient with undiagnosed Burkitt's lymphoma. Characteristic electrolyte disturbances and white emulsion like urine following laparotomy and tumor handling intraoperatively suggested the diagnosis.

Two unusual nerve abscesses--lepromatous leprosy and pure neural leprosy: case reports.

We report two cases of nerve abscesses, one suffering from lepromatous leprosy (LL) and the other from tuberculoid neural leprosy. Neither had any signs of reactions. Both were untreated cases.