Curcumin-Functionalized Electrospun Nanofibrous Membranes with Antimicrobial Activity for Wound Healing.

Chronic or improperly healed wounds, either as a result of extended trauma or prolonged inflammatory response, affect a significant percentage of the world population. Hence, there is a growing interest in the development of biomimetic scaffolds that expedite wound closure at the early stages. Curcumin (Cur) is a plant-derived polyphenol with antimicrobial activity, and it accelerates the wound contraction rate.

The use of proximal fragment transverse Kirschner wire as a joystick to correct rotational displacement in Gartland type III pediatric supracondylar humerus fractures: a novel technique.

Supracondylar humerus fractures comprise of a major part in pediatric trauma cases. They result from a fall on an outstretched hand. The rotational components of Gartland type III fractures if not corrected appropriately can lead to cubitus varus (gun stock deformity).

Finerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy.

Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays. The mineralocorticoid receptor (MR) is a classical ligand-activated nuclear transcription factor. It is expressed in the renal intrinsic and immune cells, especially macrophages.

The Enhancer-Promoter-Mediated Transcription During Neurite Regrowth of Injured Cortical Neurons.

Brain injuries can result from accidents, warfare, sports injuries, or brain diseases. Identifying regeneration-associated genes (RAGs) during epigenome remodeling upon brain injury could have a significant impact on reducing neuronal death and subsequent neurodegeneration for patients with brain injury. We previously identified several WNT genes as RAGs involved in the neurite regrowth of injured cortical neurons.

Fluid management in hemorrhagic shock.

Purpose Of Review: Fluid management in hemorrhagic shock is a controversial topic, and there are evolving clinical guidelines and evidence-based practice. This review aims to highlight the physiological aspects in the light of current evidence on which volume replacement solution to use.

Recent Findings: Current evidence and international guidelines are shifting from a liberal to a restrictive fluid resuscitation strategy, emphasizing the potential risks associated with aggressive fluid therapy.

Bleeding management in pelvic trauma: state of the art.

Purpose Of Review: Bleeding complications from pelvic injuries occur after high-energy trauma as well as after low-energy trauma in elderly patients and are the main contributors to mortality. Demographic changes necessitate focussing on both entities and targeted therapies throughout the course of management.

Recent Findings: This article reviews the recent evidence and expertise on bleeding management for haemodynamically unstable patients with pelvic fractures with insights from prehospital care to trends in resuscitation and endovascular techniques and revival of older strategies, to challenges of definitive treatment.

Examining acquired brain injury-associated symptoms and fluid-based biomarkers in females surviving intimate partner violence: An observational pilot study protocol.

Background: Acquired brain injury (ABI), including traumatic brain injury and hypoxic/anoxic injury, presents significant public health concerns; however, existing literature has focused primarily on male populations, such as military personnel and contact sports participants. Sex-related differences in ABI outcomes necessitate focused research due to potential heightened risk and distinct physiological responses among females.

Objectives: This pilot study aims to explore fluid-based biomarkers for neurological injury and inflammation in females experiencing intimate partner violence (IPV)-related assaults to the head, neck, or face.

Amniotic membrane hydrogel as novel injectable platform in combination with metformin for treatment of sciatic nerve injury.

Peripheral nerve tissue engineering is a field that uses cells, growth factors and biological scaffold material to provide a nutritional and physical support in the repair of nerve injuries. The specific properties of injectable human amniotic membrane-derived hydrogel including growth factors as well as anti-inflammatory and neuroprotective agents make it an ideal tool for nerve tissue repair, and metformin may also aid in nerve regeneration. The aim of this study was to investigate the effects of hydrogel derived from amniotic membrane (AM) along with metformin (MET) administration in the repair of sciatic nerve injury in male rats.

Enhanced personalized prediction of baseball-related upper extremity injuries through novel features and explainable artificial intelligence.

Upper extremity injuries in baseball players demand advanced prevention. Our study analyzed clinical features using machine learning techniques to provide precise and individualized injury risk assessment and prediction. We recruited 98 baseball players and collected data on glenohumeral internal/external rotation, posterior capsule thickness, supraspinatus tendon thickness, acromiohumeral distance, and occupation ratio.

Amygdala Structure and Function: Association With Transdiagnostic Trauma Severity in Anxiety and Mood Disorder Patients.

Reductions in both the size of the amygdala and functional activity during emotional processing have been independently associated with trauma exposure and severity, raising the question of whether reduced volume prompts reduced functional activation. In this multimodal assessment, the relationship between amygdala structure and function was investigated in mood and anxiety patients to determine their covariation and their relationship to trauma magnitude. Overall, amygdala volume and functional emotional reactivity were unrelated, with smaller volumes and reduced emotional reactivity each independently predicting trauma magnitude for women, and mediation analysis did not support a hypothesis that the relationship between reduced functional activity and trauma severity depends on amygdala volume.

How to use properly the POL-RISK algorithm developed for 10-year prediction of osteoporotic fractures in daily practice.

Introduction: Osteoporosis is one of the most common diseases in elderly subjects. Accurate assessment of fracture risk is essential in the management of osteoporotic patients. The aim of the study was to present the optimal manner of using a method designed for fracture risk prediction, e.

Assessment of fracture risk based on FRAX score and Polish guidelines in patients with newly diagnosed osteoporosis.

Introduction: The authors of the latest recommendations state that osteoporosis diagnosis should not rely solely on densitometric (DXA) criteria. Fracture risk assessment is crucial for determining diagnosis and intervention thresholds. Comprehensive assessment of fracture risk requires consideration of bone mineral density (BMD) results, use of risk calculators like Fracture Risk Assessment Tool (FRAXTM), and analysis of clinical and lifestyle factors.

Fracture risk assessment based on FRAX scores and Polish guidelines in patients with newly diagnosed osteopaenia.

Introduction: A densitometric diagnosis of osteoporosis qualifies patients to a diagnostic-therapeutic process, but densitometric evaluation may not be sufficient for osteopaenic patients. Therefore, it is essential to assess osteoporosis risk factors, fracture history, and 10-year fracture risk, and classify patients into low-, medium-, high-, or very high-risk categories. In our study, we aimed to assess the risk of fractures in patients with newly diagnosed osteopaenia and determine the percentage of patients at high and very high risk of fracture.

Efficacy and Safety of Chemical Venous Thromboembolism Prophylaxis in Spine Trauma Patients: A Systematic Review and Meta-analysis Comparing Anticoagulant Types.

Study Design: Systematic review and meta-analysis.

Objective: To determine whether venous thromboembolism (VTE) prophylaxis is necessary after spine trauma and to assess the efficacy and safety profiles of anticoagulation agents.

Summary Of Background Data: Venous stasis, endothelial disruption, hypercoagulability, and orthopedic injury in spine trauma predispose 12%-64% of patients to deep vein thrombosis (DVT).

Device Survival After Pediatric Cochlear Implant Surgery: A 15-Year Single-Center Retrospective Analysis.

Objective: To evaluate device survival and identify risk factors for failure in pediatric cochlear implant (CI) surgery to guide strategies for minimizing failure rates and improving survival outcomes.

Methods: A retrospective analysis was conducted on pediatric patients who underwent CI surgery at the Children's Hospital, Zhejiang University School of Medicine, from September 2008 to September 2023. Device survival was assessed using the Kaplan-Meier method while independent factors influencing device survival were analyzed using the log-rank test and Cox regression model.

Serum Lactate Dehydrogenase Levels Reflect the Lung Injury Extension in COVID-19 Patients at Hospital Admission.

Background: Several hematological and biochemical parameters have been related to the COVID-19 infection severity and outcomes. However, less is known about clinical indicators reflecting lung involvement of COVID-19 patients at hospital admission. Computed tomography (CT) represents an established imaging tool for the detection of lung injury, and the quantitative analysis software CALIPER has been used to assess lung involvement in COVID-19 patients.

Ophthalmology Examinations in Children With Skull Fractures and Underlying Focal Hemorrhage.

Objectives: To assess the frequency and yield of retinal examination in children below 2 years old undergoing abuse evaluations in the setting of skull fracture(s) and small underlying intracranial hemorrhage.

Methods: This cross-sectional study used CAPNET, a multicenter child physical abuse network, to identify children below 2 years with a skull fracture(s) and intracranial injury limited to an underlying small focal intracranial hemorrhage undergoing subspeciality child abuse evaluations. Our outcomes of interest were (1) the performance of a retinal examination, (2) the identification of retinal hemorrhages, and (3) associations of clinical factors and CAPNET site with the performance of retinal examinations.

Histopathologic Features of Pulp Following Uncomplicated Crown Fracture of an Immature Tooth With Concomitant Subluxation Seven Days After the Injury. A Case Report.

Reports on the histopathologic features of pulp tissue following traumatic injuries are scarce. The aim of the present clinical and histological report was to provide some novel insights about the histological condition of the pulp tissue of an immature permanent tooth, shortly after a combined injury of uncomplicated crown fracture with concomitant subluxation. A seven-year-old male patient presented with a localized buccal swelling apically on tooth #21 and with a radiographic app.

Premolar Autotransplantation to the Anterior Maxilla Region-Aesthetic Outcome and Patient Satisfaction.

Aim: The aim of this study was to assess the aesthetic results and patient satisfaction of premolars transplanted to the maxillary incisor region.

Material And Methods: In this multicenter study, 192 patients were included, with a minimum follow-up of 3 years. The aesthetic evaluation comprised two parts: Assessment of the PES/WES score using standardized intraoral photographs.

Influence of the BMI (<30 kg/m vs. ≥30 kg/m) on the Surgical Outcome of Osteochondral Lesions of the Talus: Prospective Data from the German Cartilage Registry (KnorpelRegister DGOU).

ObjectiveAim of this study was to evaluate the 24 months follow-up data of the German Cartilage Registry (KnorpelRegister DGOU, GCR) regarding the influence of body mass index (BMI) on clinical outcomes after surgical osteochondral lesions of the talus (OCT) treatment.DesignA total of 303 patients met the inclusion criteria. Pre- and post-operative Foot and Ankle Outcome Score (FAOS) total scores, subscores, and ΔFAOS were analyzed for most frequent surgical techniques (bone marrow stimulation [BMS], matrix-augmented BMS, matrix-augmented BMS with additional bone grafting) in normal weight group (NW, BMI <30 kg/m, = 228) and obese weight group (OW, BMI ≥30 kg/m, = 75).

Indirect calorimetry in traumatically injured patients: A descriptive cohort study.

Background: Trauma patients have historically been considered profoundly hypermetabolic. The purpose of this study was to describe energy expenditure using indirect calorimetry and to compare indirect calorimetry to predictive equations in trauma patients.

Methods: Indirect calorimetry was performed using a Q-NRG+ by a trained dietitian nutritionist.

Efficacy of Comprehensive Foot Strengthening Program on Foot Biomechanics and Plantar Pressure to Reduce Lower Limb Injury Risk in Male Bhangra Dancers: A Randomized Controlled Trial Protocol.

Background: Bhangra dance is vibrant and energy demanding art form involving dynamic footwork, jumps, kicks and rapid movements. Poor biomechanics and uneven plantar pressure is a crucial factor for injury among dancers thus, this study protocol aimed at evaluating the efficacy of comprehensive foot strengthening program in improving faulty foot biomechanics and plantar pressure distribution to reduce the risk of lower limb injuries among male Bhangra dancers.

Methods: A single-blinded randomized controlled trial (RCT) will be performed.

Medial opening wedge valgus intertrochanteric osteotomy for femoral neck nonunion: a femoral anatomy-preserving surgical approach.

Background: Valgus osteotomy is a femoral head-preserving surgery to treat femoral neck non-union in young, active patients. The traditional approach, however, causes medialisation of the femoral shaft during valgus correction, which alters femoral anatomy and complicates conversion to total hip arthroplasty if head osteosynthesis fails. This study aims to outline a novel surgical technique, medial opening wedge valgus intertrochanteric osteotomy (VITO), and evaluate its clinical and radiographic outcomes, focusing on restoring hip biomechanics and improving union rates.

The Relationship between Childhood Trauma and Depression in Early Adulthood: The Roles of Resilience and Personality Type.

Background: The relationship between childhood trauma and depression in early adulthood is complex and influenced by factors such as resilience and personality type. This study aims to investigate the mediating role of resilience and the moderating role of personality types in this relationship.

Methods: A total of 1059 undergraduates (mean age = 19.

Computed tomography accuracy and features in detecting open globe injuries in patients with ocular trauma: a systematic review and meta-analysis.

Open globe injuries (OGIs) can have devastating impacts on patients' lives. Early detection of OGIs is crucial for improving outcomes, as any delay in treatment can result in significant consequences. Radiological imaging, particularly computed tomography (CT), aids ophthalmologists in diagnosing this condition, especially in challenging cases.