The application of tissue engineering strategies for uterine regeneration.

Uterine injuries, particularly damages to endometrium, are usually associated with abnormal menstruation, recurrent miscarriage, pregnancy complications, and infertility. Tissue engineering using cell-based, biomolecule-based, or biomaterial and scaffold-based strategies has emerged as a novel and promising approach for uterine regeneration. Stem cells, biomolecules, and porous scaffolds used alone or, very often, used in combination as a more effective treatment means have shown great potential in promoting uterine regeneration.

Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report.

Primary gingival diffuse large B-cell lymphoma (DLBCL) with muscle invasion is rare and accounts for ~0.5% of all reported cases of extranodal lymphoma. The present study describes the case of a 49-year-old man that initially presented at Yingshan County People's Hospital (Nanchong, China) in August 2017 with a chief complaint of tenderness and swelling of the jaw.

Rehabilitative game-based system for enhancing physical and cognitive abilities of neurological disorders.

Neurological disorders affect the nervous system and can impair physical, cognitive, or emotional functions. They often result in challenges such as movement difficulties and the inability to perform daily activities. Common conditions include stroke, traumatic brain injury, and cerebral palsy.

"Golden Hour" in Road Traffic Accident Victims: Hurdles and Impact on Mortality.

Introduction Road traffic accident (RTA)-related death and disability are alarming health issues globally, which are rapidly increasing in developing countries. Timely presentation to a health center and prompt medical care are needed to prevent mortality and morbidity related to RTAs. This study was conducted to find out the hurdles in the golden hour arrival of RTA victims and to study its impact on RTA mortality at a tertiary health institute.

Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016.

Objective: This study aims to investigate the relationship between the Systemic Inflammatory Response Index (SIRI) and bone mineral density (BMD) in children and adolescents aged 8-19 years.

Methods: A cross-sectional design was used, utilizing NHANES data from 2011-2016, including 3,205 participants aged 8 to 19 years. Weighted multivariable regression analysis was conducted to assess the association between SIRI and BMD at the lumbar spine, pelvis, trunk, and whole body.

Identification of telomere-related gene subtypes and prognostic signatures in osteosarcoma.

Background: Osteosarcoma (OS) is the prevalent primary bone cancer, with a high proclivity for local invasion and metastasis. Previous studies have indicated that telomeres are closely related to prognosis of cancer, but the significance of telomere-related features in OS remains uncertain. Thus, the goal of this work is to identified telomere-related subtypes based on the telomere-related genes (TRGs).

Hand in hand with healthcare: A nationwide analysis of emergency department encounters for hand ailments.

Background: Hand ailments are frequent reasons for emergency department (ED) visits in the United States. This study analyzed the incidence, causes, outcomes, predictors of hospitalization, and healthcare utilization patterns nationwide.

Methods: This retrospective cohort study utilized data from the Nationwide Emergency Department Sample and National Readmission Database from 2016 to 2021.

Comparative efficacy of advanced and traditional wound dressings in post-operative orthopaedic care for hip and knee surgeries: A randomized controlled trial.

Background: This randomized controlled study aimed to evaluate the efficacy of three advanced dressings (Aquacel Ag®, Opsite® Post-Op, and Mepilex Border Post-Op®) versus traditional dressings in post-operative care for patients undergoing orthopaedic hip or knee surgeries.

Methods: Conducted between August and December 2022 at a tertiary care orthopaedic centre, 314 patients were randomized into four groups. Group A received Aquacel Ag®, Group B received Opsite® Post-Op, Group C received Mepilex Border Post-Op®, and Group D received traditional dressings.

Large bone defects in the tibia secondary to infection in open fractures: Report of two cases.

This paper reports on two cases of post-traumatic osteomyelitis (OM) caused by in immunocompetent patients, a rare but severe condition. , a gram-negative bacterium typically found in aquatic environments, is seldom reported as a cause of OM. The first case involved a 42-year-old male with a Gustilo-Anderson grade II open tibial fracture exposed to sewer water, leading to persistent infection despite initial treatment.

Manual therapy compared to surgery in the treatment of moderate carpal tunnel syndrome.

Purpose: The objective of this study was to assess the efficacy of manual therapy, specifically using the Maitland concept, in treating carpal tunnel syndrome (CTS), and to compare its effectiveness with surgical decompression of the median nerve.

Methods: A total of 69 patients were enrolled and divided into two groups: a control group (undergoing surgery) and treatment group (receiving manual therapy). Subgroups were formed based on gender, considering factors such as grip strength.

The psychological impact of mass shootings on emergency physician mental health.

On October 1, 2017 in Las Vegas, Nevada, the largest mass shooting in US history was committed by a shooter high above the Route 91 Harvest Festival. In light of this tragedy and the increasing incidence and prevalence of mass shootings in America, it is important to examine how exposure to traumatic events (specifically mass shootings) affects the mental health of hospital physicians through the treatment of victims. This study sought to examine how witnessing mass shootings through the treatment of shooting victims psychologically affects physicians.

Active shooter preparedness for special education classrooms.

Active shooter planning for special education classrooms requires considerations commensurate to the needs of students with mobility, cognitive, auditory, visual, and communicative limitations. The federally established Run, Hide, Fight response methodology has no modified alternative for students who are not able to meet the criteria to run, hide, or fight. School districts that implement Run, Hide, Fight plans without any modified alternatives for special education students expose a compliance lapse of the American Disabilities Act, the Department of Education's Individuals with Disabilities Education Act, and the National Preparedness Goal.

EXPRESS: Exploring Novel Non-Opioid Pathways and Therapeutics for Pain Relief.

The opioid crisis has highlighted the urgent need for alternative pain management strategies. This review explores novel non-opioid targets and pathways involved in pain modulation, highlighting advancements in understanding and therapeutic potential. Pain, a multifaceted phenomenon with nociceptive, neuropathic, and inflammatory components, involves intricate molecular signaling cascades.

EXPRESS: Loss and damage in large-diameter sensory neurons in the db/db diabetic mouse.

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. Half of DPN patients experience sensory deficits including loss of sensation and pain. Loss of sensation increases the risk of unnoticed foot injuries which combined with poor circulation and healing lead to amputation.

Traumatic stress-enhanced ethanol drinking: Sex, but not stress responsivity, alters sensitivity to the effects of a CRF-R1 antagonist and a GPR39 agonist in mice.

Background: Predator stress (PS) is used to model trauma leading to post-traumatic stress disorder, and it increases ethanol drinking in a proportion of male and female rodents. The goals of the present studies were to identify male and female mice with prior binge drinking experience that exhibited sensitivity and resilience to PS-enhanced drinking and then to test two target molecules (corticotropin releasing factor receptor 1 [CRF-R1] antagonist NBI-27914 [NBI] and G-protein coupled receptor 39 [GPR39] agonist TC-G 1008 [TC-G]) for their ability to selectively reduce PS-enhanced drinking.

Methods: Adult male and female C57BL/6J mice received seven binge ethanol sessions, a period of abstinence, and acclimation to lickometer chambers to examine the effects of NBI or TC-G on stress-associated drinking.

The effect of 807-nm light-emitting diode photobiomodulation on peripheral nerve injury.

Photobiomodulation (PBM) has demonstrated potential in promoting peripheral nerve regeneration. However, there is a limited and inconclusive study on the application of light-emitting diode (LED) for nerve injury repair. In this study, we designed an 807-nm LED device with high luminous uniformity to investigate the effects of LED-based PBM on peripheral nerve injury repair.

Are women adequately informed about the use of instrumentation during vaginal delivery? A prospective review of the information on instrumental delivery provided to pregnant women and a retrospective review of the quality of consent for instrumental delivery.

Aim: Instrumental delivery typically describes the use of ventouse or forceps to aid vaginal delivery. They are used in 10%-15% of all vaginal deliveries and in almost a third of all primiparous deliveries. They are associated with an increased risk of maternal and neonatal injury.

The association between quality of life and psychological flexibility, depressive, anxiety or insomnia symptoms in patients with persistent indoor environment-related symptoms or chronic fatigue.

Background: Persistent physical symptoms (PPS) can significantly impair health-related quality of life (HRQoL) and are often accompanied by psychiatric comorbidity. Psychological flexibility (PF), characterized by the ability to adapt functionally and congruently to diverse situations based on personal values, may play a crucial role in determining HRQoL. This study aims to examine the associations between symptoms of depression, anxiety or insomnia or PF and HRQoL among individuals with PPS associated with (i) the indoor environment (IE), (ii) chronic fatigue, or (iii) both.

Cardiac damage after polytrauma: the role of systematic transthoracic echocardiography - a pilot study.

Background: Heart injuries following polytrauma (PT) are identified as a predictor of poor outcome. The diagnostic algorithm of cardiac damage after trauma consists of the systemic measurement of cardiac damage markers, a 3-channel ECG and if there are any suspicious findings, the conduction of a transthoracic echocardiography (TTE). The aim of this study was to implement a systematic analysis of cardiac function using TTE in PT-patients.

Health service utilisation cost associated with residential fire incidents in New South Wales, Australia.

Background: Fire is a major contributor to global fatalities and disabilities and remains a prevalent threat to individuals in Australia. New South Wales (NSW) experiences over one-third of all structure fires, including residential ones, in the country and one-quarter of all associated deaths and hospital admissions. In an atmosphere of rising healthcare cost and heightened demand for its services, obtaining total cost data for residential fires is essential.

Efficacy and safety of platelet-rich plasma as an adjunct therapy to split thickness skin graft in burn patients with granulating raw wounds: a prospective, randomized, double-blind study-study protocol.

Background: Burn wounds are commonly encountered in clinical settings and the management aims at the prevention of mortality and morbidity due to disability. The platelet-rich plasma (PRP) is blood-derived biomaterial that is enriched with growth factors and cytokines that facilitate wound healing. The PRP has proven its efficacy in various other wounds, but its role in post-burn raw areas and graft take has not been validated.

Elastic stable intramedullary nails compared to locking compression plates for treating unstable distal ulnar fractures in adults: a prospective comparative study.

Background And Purpose: Distal ulna fractures often occur in conjunction with distal radius fractures and other associated injuries. Currently, there are no satisfactory internal fixation systems available for addressing unstable distal ulna fractures, and a definitive consensus on the most effective treatment approach is still lacking. The objective of this research was to evaluate the clinical outcomes of using elastic stable intramedullary nails (ESIN) compared to locking compression plates (LCP) for treating unstable distal ulnar fractures in adults.

Chlorogenic acid attenuates pyrrolizidine alkaloid-induced liver injury through modulation of the SIRT1/FXR signaling pathway.

Background: Pyrrolizidine alkaloids (PAs), recognized globally for their hepatotoxic properties, significantly contribute to liver damage through an imbalance in bile acid homeostasis. Addressing this imbalance is crucial for therapeutic interventions in PA-related liver injuries. Chlorogenic acid (Cga), a phenolic compound derived from medicinal plants, has demonstrated hepato-protective effects across a spectrum of liver disorders.

Global, regional, and national assessment of foreign body aspiration (1990-2021): novel insights into incidence, mortality, and disability-adjusted life years.

Background: Foreign body aspiration (FBA) is a preventable yet underrecognized global health challenge, contributing to substantial clinical and economic burdens. Comprehensive and comparable analyses of FBA trends across diverse populations and socioeconomic contexts remain limited. Leveraging data from the 2021 Global Burden of Disease (GBD) Study, we provide an in-depth global, regional, and national analysis of FBA trends over the past three decades, including the first evaluation of disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs).

AMD1, a cardiotoxicity target for Maduramicin.

Objective: The aim of this study was to investigate AMD1 cardiotoxicity function for Maduramicin (Mad).

Methods: SD rats were divided into control (Control) group and Mad treatment (3.5 mg/kg) group (Mad).