The incidence and cause of reoperation for complications after volar locking plate fixation of distal radial fractures.

Background: Distal radial fractures are the most common upper extremity fractures. Volar locking plate fixation has become the standard surgical treatment, providing stable angular fixation, early rehabilitation, and effective support for comminuted and osteopenic bones. This study aimed to analyze the incidence and causes of major complications requiring secondary surgeries following volar plating for distal radial fractures and to investigate the correlation between demographic factors and postoperative outcomes, including major complications and reoperation.

Cytokine therapy of acute radiation syndrome.

Radiological accidents/incidents are common with nearly 400 reported since 1944 exposing about 3000 people to substantial doses of ionizing radiations with 127 deaths. Damage to hematopoietic stem and progenitor cells with resulting bone marrow failure is a common consequence of exposure to whole body acute high-dose and -dose-rate ionizing radiations and is termed hematopoietic-acute radiation syndrome, or H-ARS. Therapy of H-ARS includes transfusions, anti-bacterial and -viral drugs, molecularly-cloned hematopoietic growth factors and hematopoietic cell transplants.

Robotic-assisted surgical treatment of complex giant incisional hernias: A report of 3 cases.

Incisional hernia of abdominal wall is one of the most common complications following open surgery. Giant incisional hernia of abdominal wall is defined as having a maximum defect diameter >12 cm or a hernia sac volume-to-abdominal cavity volume ratio >20%. The Primary treatment for giant incisional hernia of abdominal wall is surgical repair; however, both open surgery and conventional laparoscopic surgery are associated with significant technical difficulty, high surgical trauma, frequent postoperative complications, and suboptimal outcomes.

ZNF667 alleviates the inflammatory damage in intervertebral disc degeneration via inhibiting NF-κB signaling pathway.

Objectives: With the aging population, the incidence of intervertebral disc degeneration (IDD) is increasing every year. The pathogenesis of IDD is complex, and there are currently no effective treatment options. This study aims to investigate the specific function and underlying mechanism of zinc finger protein 667 (ZNF667) in the inflammatory damage of nucleus pulposus cells in IDD.

Evaluation of the Patient-Specific Functional Scale for monitoring paediatric injury patients at a zonal referral hospital in Northern Tanzania.

Background: Injuries are a major cause of morbidity and mortality among paediatric populations in low- and middle-income countries (LMICs). The Patient-Specific Functional Scale (PSFS) is a commonly used tool to assess functional recovery. This study aims to evaluate the psychometric properties of the PSFS for monitoring paediatric injury patients at a zonal referral hospital in Northern Tanzania.

Excellent Clinical and Radiological Mid-term Outcomes of the Arthroscopic "Double-Inlay" Eden-Hybinette Procedure for Bone Defects Exceeding 20%: A 5-Year Case Series.

Background: Eden-Hybinette procedure can maximize the restoration of the glenoid defect by harvesting a proper size of iliac bone block. We developed an arthroscopic "double-inlay" Eden-Hybinette procedure to achieve better bone union of the graft. The aim of this study was to evaluate the clinical and radiological mid-term outcomes of the arthroscopic "double-inlay" Eden-Hybinette procedure for bone defects exceeding 20%.

Invasive Salmonella Typhimurium Colonizes Gallbladder and Contributes to Gallbladder Carcinogenesis through Activation of Host Epigenetic Modulator KDM6B.

Gallbladder stones alone do not explain the risk of gallbladder cancer (GBC) as the sole etiological factor. Chronic microbial infection, particularly Salmonella, has been implicated in GB carcinogenesis, but its causative role and the underlying mechanisms are largely unknown. We studied gut and gallbladder tissue microbiome through targeted metagenomics to identify pathogenic bacteria in GBC.

Synergistic photothermal-sonodynamic therapy for antibacterial and immune reprogramming in chronic osteomyelitis.

The development of antibiotic resistance and inadequate immune response in chronic inflammation pose significant challenges in treating chronic osteomyelitis. As accepted non-antibiotic antimicrobial therapies, sonodynamic therapy (SDT) and photothermal therapy (PTT) are recognized for their effectiveness in eliminating bacteria and promoting tissue repair, rendering them promising therapeutic strategies for treating bacterial infections and preventing the emergence of drug-resistant bacteria. However, the antimicrobial action and efficacy in promoting tissue repair depend on the activation status of the host immune system.

Improving Consent in Trauma: Recall (ICIT: Recall) : a multicentre study protocol of consent for hip fractures.

Aims: This study investigates the effectiveness and adequacy of the informed consent process for patients undergoing hip fracture surgery. While informed consent is a legal and ethical responsibility, factors in the trauma setting can impair patients' understanding and retention of information. This study seeks to evaluate patients' recall of perioperative complications and explore their perceptions of the consent process.

Major trauma coordinators in the UK: A survey of demographics and role functions.

Background: Trauma coordinators (TCs) play a key role in managing patients with complex injuries, coordinating care across multiple specialties. This study aimed to investigate the current role functions of TCs in the UK, compare them to findings from 2015, and explore differences between TCs in Major Trauma Centres (MTCs) and Trauma Units (TUs).

Methods: A UK-wide cross-sectional survey was conducted using an online questionnaire.

Potentially low-value operative care in abdominal trauma: A retrospective National Trauma Data Bank study.

Background: We currently lack national data on adherence to American College of Surgeons recommendations on nonoperative management for hemodynamically stable adults with solid-organ injuries. We aimed to estimate the incidence and interhospital variation in potentially low-value operative management for adults with blunt solid abdominal organ injuries.

Methods: We included adults with blunt solid-organ injury eligible for nonoperative management (grades I-IV spleen and liver and grade I-III kidney, hemodynamically stable on arrival, and no blood products used in the emergency department) who were admitted to trauma centers in the United States that submitted data to the National Trauma Data Bank between 2016 and 2019.

Finger osteochondroma presenting as non-traumatic mallet finger in pediatric: A case report.

Introduction And Importance: A terminal extensor tendon disruption, with or without bony avulsion, may lead to a mallet deformity. In most cases, trauma precedes deformity. Non-traumatic causes are less probable.

Psychological resilience to trauma and longitudinal sleep outcomes among current and former nurses.

Objective: A life-disrupting stressor (e.g. pandemic) may cause or exacerbate poor sleep health; resilience may offset impacts.

The child behind the victim: Survivor experiences of children's harmful sexual behavior.

Background: At least 50 % of child sexual abuse involves perpetration by children, referred to as "harmful sexual behavior". Recently, the sexual abuse sector has focused, importantly, on the child behind the "perpetrator" to support developmentally-appropriate and trauma-informed practice. However, the experiences of victim-survivors of children's sexually abusive behavior are underexplored.

Drop jump vertical kinetics identify male youth soccer players at greater risk of non-contact knee injury.

Objectives: To determine associations between drop-jump vertical kinetics and acute non-contact knee injury-risk in male youth soccer players.

Design: Prospective cohort study.

Setting: Professional soccer academies.

Quercetin-derived carbon dots promote proliferation and migration of Schwann cells and enhance neurite outgrowth.

Quercetin, a flavonoid known for its antioxidant properties, has recently garnered attention as a potential neuroprotective agent for treatment of the injured nervous system. The repair of peripheral nerve injuries hinges on the proliferation and migration of Schwann cells, which play a crucial role in supporting axonal growth and myelination. In this study we synthesized Quercetin-derived carbon dots (QCDs) and investigated their effects on cultured Schwann cells and the NG108-15 cell line.

Post-Concussion Brain Changes Relative to Pre-Injury White Matter and Cerebral Blood Flow: A Prospective Observational Study.

Background And Objectives: Medical clearance for return to play (RTP) after sports-related concussion is based on clinical assessment. It is unknown whether brain physiology has entirely returned to preinjury baseline at the time of clearance. In this longitudinal study, we assessed whether concussed individuals show functional and structural MRI brain changes relative to preinjury levels that persist beyond medical clearance.

Isolated Fibula Fracture With Development of Acute Compartment Syndrome.

Compartment syndrome is an orthopaedic emergency with moderate-to-severe sequela (pain, muscle contracture, nerve damage, infection, rhabdomyolysis, renal failure, etc.) if inadequately treated and can be difficult to diagnose in a timely fashion. Further complicating timely diagnosis are atypical presentations resulting in compartment syndrome.

Burn injury-induced G-CSF secretion reduces spic+ erythroblastic island macrophages in the bone marrow and impairs medullary erythropoiesis.

The erythroblastic island (EBI) functions as a niche in which erythroblastic island macrophages (EBIMφs) are positioned within rings of erythroblasts, providing support and signals that orchestrate efficient erythropoiesis. We postulated burn injury impacts the EBI niche, given the nearly universal presence of anemia and inflammation in burn patients, and a divergent myeloid transcriptional signature that we observed in murine bone marrow following burn injury, in which granulocyte colony-stimulating factor (G-CSF) secretion broadly attenuated the expression of EBIMφ marker genes. Notably, we identified the heme-induced transcription factor Spi-C as a robust marker of EBIMφs in Spicigfp/igfp mice.

Do Widespread or Selective Invasive Monitoring Increase the Rate of Fasciotomies for Tibial Shaft and Plateau Fractures, or Affect the Incidence of Possible Missed Compartment Syndrome?

Introduction: To report the incidence of lower leg fasciotomies in tibial shaft and plateau fractures and explore the incidence of potential missed acute compartment syndrome (ACS) with widespread, selective, or no invasive monitoring (IM).

Methods: This is a retrospective review of adult patients with diaphyseal tibial fractures (Orthopaedic Trauma Association 42A-C), and proximal tibial fractures (Orthopaedic Trauma Association 41A-C) treated surgically at a Level 1 trauma center from 2001 to 2020. Main outcomes of interest include lower extremity fasciotomy rates and incidence of potential missed ACS (abnormal neurovascular examination, sensory changes, chronic pain, claw toes, or amputation) in diaphyseal and proximal tibial fractures at three time intervals: widespread use of IM (w-IM) (2000 to 2010), selective IM (s-IM) (2011 to 2015), and clinical examination with a high index of suspicion alone without IM (CES), 2016 to 2020.

Itaconate restrains acute proinflammatory activation of microglia MG after traumatic brain injury in mice.

Traumatic brain injury (TBI) rapidly triggers proinflammatory activation of microglia, contributing to secondary brain damage post-TBI. Although the governing role of energy metabolism in shaping the inflammatory phenotype and function of immune cells has been increasingly recognized, the specific alterations in microglial bioenergetics post-TBI remain poorly understood. Itaconate, a metabolite produced by the enzyme aconitate decarboxylase 1 [IRG1; encoded by immune responsive gene 1 ()], is a pivotal metabolic regulator in immune cells, particularly in macrophages.

A Retrospective Comparison of Cephalomedullary Nail Fixation of Intertrochanteric Femur Fractures Treated With Locked Versus Backed-off Set Screws.

Introduction: Excessive lag screw sliding after cephalomedullary nail fixation of intertrochanteric fractures can be problematic. Set screws are typically inserted to engage the lag screw and backed off to allow for sliding. The purpose of this study was to determine whether statically locking set screws affected lag screw sliding or cutout.

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept.

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. Here, we developed an implantable spinal cord neuroprosthesis operating in a closed loop to promote robust activity during walking and cycling assisted by robotic devices.