2 results match your criteria: "Department of Thoracic Medicine Chang Gung Memorial Hospital Taoyuan Taiwan.[Affiliation]"
Multiple Myeloma Complicated With Bronchiolitis Obliterans Syndrome After Allogeneic Haematopoietic Stem Cell Transplantation and Subsequently Underwent Lung Transplantation Successfully: A Case Report.
Respirol Case Rep
March 2025
Department of Thoracic Medicine Chang Gung Memorial Hospital Taoyuan Taiwan.
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for multiple myeloma; however, the development of chronic graft-versus-host disease remains a significant challenge. Bronchiolitis obliterans syndrome (BOS) is one of the complications. Even with available medications for treatment, the prognosis of BOS remains poor.
View Article and Find Full Text PDFOxidative stress mediates nucleocytoplasmic shuttling of KPNA2 via AKT1-CDK1 axis-regulated S62 phosphorylation.
FASEB Bioadv
August 2024
Graduate Institute of Biomedical Sciences, College of Medicine Chang Gung University Taoyuan Taiwan.
Article Synopsis
- Karyopherin α 2 (KPNA2) is a protein that plays a key role in transporting other proteins between the nucleus and cytoplasm and is involved in essential cellular activities like cell cycle control and apoptosis.
- This study focuses on how oxidative stress influences the distribution of KPNA2, specifically showing that oxidative stress leads to increased retention of KPNA2 in the nucleus by reducing its serine 62 phosphorylation through AKT1 activation.
- Findings suggest that the AKT1-CDK1 signaling pathway is crucial in determining the localization and functions of KPNA2 during oxidative stress, as it affects S62 phosphorylation and, consequently, KPNA2's interaction with other proteins involved in gene transcription regulation.