1 results match your criteria: "Department of Surgery and the University of Wisconsin Carbone Cancer Center[Affiliation]"
Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method.
Cancer
April 2011
Endocrine Surgery Research Laboratory, Department of Surgery and the University of Wisconsin Carbone Cancer Center, Madison, Wisconsin 53792, USA.
Background: Carcinoids are neuroendocrine (NE) tumors with limited treatment options. Notch activation has been shown to suppress growth and hormone production in carcinoid cells.
Methods: The purpose of this study was to provide a process for identifying Notch activating compounds via high-throughput screening (HTS) and to validate the effects of the strongest hit from the 7264 compounds analyzed: resveratrol (RESV).