2 results match your criteria: "Department of Surgery University of Virginia Charlottesville VA.[Affiliation]"
Effect of Cardiopulmonary Bypass on SARS-CoV-2 Vaccination Antibody Levels.
J Am Heart Assoc
September 2023
Division of Cardiac Surgery, Department of Surgery University of Virginia Charlottesville VA USA.
Article Synopsis
- Adults undergoing heart surgery are at high risk for respiratory complications, including COVID-19, but being fully vaccinated can help reduce this risk.
- This study evaluated the impact of cardiopulmonary bypass (CPB) on COVID-19 antibody levels in 77 patients who had surgery; it found that antibody concentrations significantly dropped immediately after surgery but returned to pre-surgery levels within a month.
- The research highlights the importance of monitoring COVID-19 vaccination status in cardiac surgery patients, as there was one reported case of COVID-19 pneumonia that resulted in death, emphasizing the need for enhanced safety measures during and after surgery.
Background We previously demonstrated that ischemically injured cardiomyocytes release cell-free DNA and HMGB1 (high mobility group box 1 protein) into circulation during reperfusion, activating proinflammatory responses and ultimately exacerbating reperfusion injury. We hypothesize that cell-free DNA and HMGB1 mediate myocardial ischemia-reperfusion injury by stimulating plasmacytoid dendritic cells (pDCs) to secrete type I interferon (IFN-I). Methods and Results C57BL/6 and interferon alpha receptor-1 knockout mice underwent 40 minutes of left coronary artery occlusion followed by 60 minutes of reperfusion (40'/60' IR) before infarct size was evaluated by 2,3,5-Triphenyltetrazolium chloride-Blue staining.
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