Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes.

Background: We explored the association of C-peptide (marker of secreted insulin), proinsulin and proinsulin ⁄C-peptide ratio (PI/C) (markers of beta-cell endoplasmic reticulum [ER] stress) with undercarboxylated (uOC) and carboxylated osteocalcin (cOC) and their ratio (uOC/cOC) in children with recently diagnosed type 1 (T1D) or type 2 diabetes (T2D), and the correlation of these variables with partial remission (PR) in children with T1D.

Methods: Demographic and clinical data of children with new-onset diabetes (n = 68; median age = 12.2 years; 33.