1 results match your criteria: "Department of Surgery Pietro Valdoni-University of Rome La Sapienza[Affiliation]"
Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells.
J Surg Res
January 2003
Department of Surgery Pietro Valdoni-University of Rome La Sapienza, Via A. Scarpa 14, 00161, Rome, Italy.
Background: Vascular endothelial growth factor (VEGF), a highly specific chemotactic and mitogenic factor for vascular endothelial cells (EC), appears to be involved in the development of atherosclerosis. The purpose of our study was to assess if VEGF might indirectly stimulate SMC migration and proliferation in a EC-SMC coculture system, through the mediation of growth factors released by EC.
Methods: Bovine aortic SMC were cocultured with bovine aortic EC treated with hrVEGF, to assess SMC proliferation and migration.