Potential Mediators for Treatment Effects of Novel Diabetes Medications on Cardiovascular and Renal Outcomes: A Meta-Regression Analysis.

Background: Prior research suggests clinical effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) are mediated by changes in glycated hemoglobin, body weight, systolic blood pressure, hematocrit, and urine albumin-creatinine ratio. We aimed to confirm these findings using a meta-analytic approach.

Methods And Results: We updated a systematic review of 9 GLP-1RA and 13 SGLT2i trials and summarized longitudinal mediator data.

Maternal exposure to work schedule unpredictability and child behavior.

Objective: This article estimates the association between maternal exposure to unpredictable work schedules in the service sector and child internalizing and externalizing behavior.

Background: Precarious work is widespread and characterized by low wages, few benefits, and nonstandard schedules. But working parents, especially in the service sector, contend with unpredictable work schedules as well.

When parents are not present: Decision-making dynamics for young children's health and illness in migrant-sending households in rural Cambodia.

As migration rates increase globally, an increasing proportion of children in low- and middle-income countries live apart from their parents. In particular, skipped-generation households are becoming more common, with grandparents serving as primary caregivers for young grandchildren whose parents migrate and provide remittance support. Yet, how families living apart make decisions for young children's healthcare is not well understood.

Professionally Responsible Disclosure of Genomic Sequencing Results in Pediatric Practice.

Genomic sequencing is being rapidly introduced into pediatric clinical practice. The results of sequencing are distinctive for their complexity and subsequent challenges of interpretation for generalist and specialist pediatricians, parents, and patients. Pediatricians therefore need to prepare for the professionally responsible disclosure of sequencing results to parents and patients and guidance of parents and patients in the interpretation and use of these results, including managing uncertain data.

Older women in the post-Reagan era.

This article explores the social, economic, and institutional factors that affect older women throughout the life cycle, and recent policy and ideological changes that will continue to affect older women in the decades ahead. The situation of the older woman is shown to result from lifelong patterns of socioeconomic and gender stratification in the larger society. The consequences for women flow from the complex and often subtle relationships in the social institutions of the family, the labor market, and the state and its social policy.