513 results match your criteria: "Department of Respiratory Therapy Georgia College & State University.[Affiliation]"
Clinical presentations, systemic inflammation response and ANDC scores in hospitalized patients with COVID-19.
Sci Rep
September 2024
Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fu-Shin Street, Kwei-Shan, Taoyuan, 333, Taiwan.
The association of anosmia/ageusia with a positive severe respiratory syndrome coronavirus 2 (SARS-CoV-2) test is well-established, suggesting these symptoms are reliable indicators of coronavirus disease 2019 (COVID-19) infection. This study investigates the clinical characteristics and systemic inflammatory markers in hospitalized COVID-19 patients in Taiwan, focusing on those with anosmia/ageusia. We conducted a retrospective observational study on 231 hospitalized COVID-19 patients (alpha variant) from April to July 2021.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
- In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
- There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
Low Versus Standard Intensity Heparin Protocols in Adults Maintained on Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study.
J Pharm Pract
September 2024
Department of Pharmacy, Wellstar MCG Health, Augusta, GA, USA.
Patients maintained on extracorporeal membrane oxygenation (ECMO) often require systemic anticoagulation to prevent circuit clotting and systemic thromboembolic complications. The optimal intensity of anticoagulation to balance the risk of bleeding and prevention of thrombotic complications in this patient population is not well described. To compare bleeding events in patients on ECMO anticoagulated with standard vs low intensity heparin protocols.
View Article and Find Full Text PDFDefinitions of adverse events associated with extracorporeal membrane oxygenation in children: results of an international Delphi process from the ECMO-CENTRAL ARC.
Lancet Child Adolesc Health
October 2024
Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA; Susan B Meister Child Health Evaluation and Research Center, Division of General Pediatrics, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Article Synopsis
- ECMO is a complex and risky life support system that lacks standardized definitions for adverse outcomes, which hinders effective research and practices.
- The ECMO-CENTRAL ARC was formed to create clear definitions for pediatric ECMO adverse events, using input from literature and a diverse expert panel.
- After three rounds of surveys, 13 key adverse event definitions were established and unanimously agreed upon by the voting experts.
Bruton tyrosine kinase inhibitor monotherapy in B-cell lymphoma and risk of infection: A systematic review and meta-analysis of randomized controlled trials.
Hematol Oncol
September 2024
Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Athens, Georgia, USA.
Article Synopsis
- BTK inhibitors show promising efficacy for treating chronic lymphocytic leukemia and B-cell lymphomas, but their use can lead to infections, impacting patient outcomes.
- A systematic review and meta-analysis of 12 studies revealed a 55% increased risk of upper respiratory tract infections (URTIs) among patients on BTK inhibitors, although more severe infections like pneumonia did not show statistically significant elevation in risk.
- The study underscores the importance of monitoring and preventative measures for infections in patients receiving BTK inhibitor therapy to ensure better management of their health.
Effects of Antihypertensive Therapy During Pregnancy on Postpartum Blood Pressure Control.
Obstet Gynecol
October 2024
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, University of Pennsylvania, Philadelphia, Pennsylvania, University of Texas at Houston, Houston, Texas, Columbia University, New York, New York, Duke University, Durham, North Carolina, St. Luke's University Health Network, Bethlehem, Pennsylvania, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, Metro Health/Case Western University, Cleveland, Ohio, Indiana University, Indianapolis, Indiana, Drexel University College of Medicine, Philadelphia, Pennsylvania, University of Utah Health, Salt Lake City, Utah, University of Texas Southwestern, Dallas, Texas, Intermountain Healthcare, Salt Lake City, Utah, Ochsner Health, New Orleans, Louisiana, University of Texas Medical Branch, Galveston, Texas, St. Peters University Hospital, New Brunswick, New Jersey, Washington University in St. Louis, St. Louis, Missouri, University of Mississippi Medical Center, Jackson, Mississippi, Magee Women's Hospital and University of Pittsburgh, Pittsburgh, Pennsylvania, The Ohio State University, Columbus, Ohio, Rutgers University-Robert Wood Johnson Medical School, Brunswick, New Jersey, Medical College of Wisconsin, Milwaukee, Wisconsin, University of South Alabama at Mobile, Mobile, Alabama, Weill Cornell University, New York City, New York, Yale University, New Haven, Connecticut, NYU Langone Hospital-Long Island, Mineola, New York, University of Colorado, Aurora, Colorado, Emory University, Atlanta, Georgia, Denver Health, Denver, Colorado, University of California, San Francisco, San Francisco, California, NewYork-Presbyterian Queens Hospital, Flushing, New York, Stanford University, Stanford, California, Arrowhead Regional Medical Center, Colton, California, Tulane University, New Orleans, Louisiana, Wright State University and Miami Valley Hospital, Dayton, Ohio, University of Kansas Medical Center, Kansas City, Kansas, Medical University of South Carolina, Charleston, South Carolina, Vanderbilt University School of Medicine, Nashville, Tennessee, and Tufts University School of Medicine, Boston, Massachusetts; Beaumont Hospital, Grand Rapids, Michigan; the Center for Women's Reproductive Health, the Department of Biostatistics, the Department of Pediatrics, and the Department of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama; the Christiana Care Center for Women's and Children Health Research, Newark, Delaware; Zuckerberg San Francisco General Hospital, San Francisco, California; the Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland; Virtua Health, Marlton, New Jersey; Oregon Health and Science University, Portland, Oregon; the Department of Obstetrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas; the Fetal Care Center of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Good Samaritan Hospital, Cincinnati, Ohio; the Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey; Obstetrics and Gynecology/Maternal-Fetal Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; the Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Lehigh Valley Health Network, Allentown, Pennsylvania; and Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio.
Objective: To compare differences in postpartum blood pressure (BP) control (BP below 140/90 mm Hg) for participants with hypertension randomized to receive antihypertensive treatment compared with no treatment during pregnancy.
Methods: This study was a planned secondary analysis of a multicenter, open-label, randomized controlled trial (The CHAP [Chronic Hypertension and Pregnancy] trial). Pregnant participants with mild chronic hypertension (BP below 160/105 mm Hg) were randomized into two groups: active (antihypertensive treatment) or control (no treatment unless severe hypertension, BP 160/105 mm Hg or higher).
Antiviral agents and therapeutics against respiratory viruses.
Expert Opin Investig Drugs
November 2024
TrippBio, Jacksonville, FL, USA.
Introduction: Respiratory viruses are responsible for significant worldwide morbidity and mortality. While vaccines are highly effective at reducing the morbidity and mortality associated with viral infections, this protection is incomplete. It requires a high degree of compliance, which is hindered by vaccine hesitancy.
View Article and Find Full Text PDFFrom the International Association for the Study of Lung Cancer Early Detection and Screening Committee: Terminology Issues in Screening and Early Detection of Lung Cancer-International Association for the Study of Lung Cancer Early Detection and Screening Committee Expert Group Recommendations.
J Thorac Oncol
December 2024
Cancer Control & Evidence Integration, Ontario Health (Cancer Care Ontario), Toronto, Ontario, Canada; Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
Introduction: To facilitate global implementation of lung cancer (LC) screening and early detection in a quality assured and consistent manner, common terminology is needed. Researchers and clinicians within different specialties may use the same terms but with different meanings or different terms for the same intended meanings.
Methods: The Diagnostics Working Group of the International Association for the Study of Lung Cancer Early Detection and Screening Committee has analyzed and discussed relevant terms used on a regular basis and suggests recommendations for consensus definitions of terminology applicable in this setting.
A Consensus Statement on the Administration of Systemic Bevacizumab in Patients with Recurrent Respiratory Papillomatosis.
Laryngoscope
December 2024
Department of Otolaryngology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
Article Synopsis
- A group of medical experts worked together to create guidelines for using a medicine called bevacizumab to help patients with a disease called recurrent respiratory papillomatosis (RRP).
- They reviewed many studies and gathered opinions from doctors who treat both kids and adults with this condition to decide how best to use the medicine.
- Their findings include important information on which patients might benefit from this treatment, how to give the medicine, and when to stop or restart it, helping to change how RRP is treated.
Adaptation of SafeCare, an evidence-based parenting program, for caregivers of infants in the neonatal intensive care unit.
Appl Nurs Res
August 2024
College of Nursing, Ohio State University, Columbus, OH 43210, USA.
Background: While there are several parenting programs for NICU caregivers, no studies, to our knowledge, have developed parenting programs aimed at preventing child maltreatment that specifically address these parental factors: parental stress, parental self-efficacy, and positive parent-infant interaction.
Objectives: The objectives of this study were to: 1) Identify adaptations and/or augmentations needed to optimize SafeCare® for NICU caregivers, and 2) Examine the acceptability and preliminary effects of the adapted SafeCare NICU (SCNC) program with NICU caregivers.
Methods: This study consisted of two phases: formative (phase one) and pilot (phase two).
The impact of imposter syndrome on self-esteem and intention to quit among respiratory therapy (RT) students in Saudi Arabia.
SAGE Open Med
June 2024
Department of Respiratory Care Services, King Abdulaziz Medical City, Ministry of National Guard, Jeddah, Saudi Arabia.
Introduction: Imposter syndrome is common among health disciplinary students, leading to serious consequences. However, the impact of imposter syndrome on self-esteem and quitting intention among respiratory therapy students has not been well researched.
Objective: To report on the prevalence of imposter syndrome and assess its impacts on self-esteem and quitting intention among respiratory therapy students in Saudi Arabia.
A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis.
Lancet Glob Health
August 2024
Campaigns in Global Health, London, UK. Electronic address:
Optimal Timing of Delivery for Pregnant Individuals With Mild Chronic Hypertension.
Obstet Gynecol
September 2024
Departments of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah, University of Texas at Houston, Houston, and University of Texas Medical Branch, Galveston, Texas, University of Pennsylvania and Drexel University College of Medicine, Philadelphia, and Magee Women's Hospital and University of Pittsburgh, Pittsburgh, Pennsylvania, University of North Carolina at Chapel Hill, Chapel Hill, and Duke University, Durham, North Carolina, Columbia University and Weill Cornell University, New York, and NYU Langone Hospital-Long Island, Long Island, and NewYork-Presbyterian Queens Hospital, Flushing, New York, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, Indiana University, Indianapolis, Indiana, University of Alabama at Birmingham, Birmingham, and University of South Alabama at Mobile, Mobile, Alabama, UnityPoint Health-Meriter Hospital/Marshfield Clinic, Madison, and Medical College of Wisconsin, Milwaukee, Wisconsin, Washington University, St. Louis, Missouri, University of Mississippi Medical Center, Jackson, Mississippi, The Ohio State University, Columbus, and Wright State University and Miami Valley Hospital, Dayton, Ohio, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, Yale University, New Haven, Connecticut, University of Colorado, Aurora, and Denver Health, Denver, Colorado, Emory University, Atlanta, Georgia, University of California, San Francisco, San Francisco, Stanford University, Stanford, and Arrowhead Regional Medical Center, Colton, California, Beaumont Hospital, Michigan, Grosse Pointe, Michigan, Oregon Health & Science University, Portland, Oregon, Tulane University, New Orleans, Louisiana, and University of Kansas Medical Center, Kansas City, Kansas; the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital, Houston, and the Department of Women's Health, University of Texas at Austin, Austin, Texas; the Department of Biostatistics, the Division of Neonatology, Department of Pediatrics, and the Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama; Ochsner Baptist Medical Center, New Orleans, Louisiana; St. Luke's University Health Network, Fountain Hill, and the Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Lehigh Valley Health Network, Allentown, Pennsylvania; MetroHealth System, Cleveland, and the Fetal Care Center of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Intermountain Healthcare, Ogden, Utah; Christiana Care Health Services, Newark, Delaware; St. Peters University Hospital, New Brunswick, Virtua Health, Marlton, and the Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey; Zuckerberg San Francisco General Hospital, San Francisco, California; the Department of Obstetrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Obstetrics and Gynecology/Maternal-Fetal Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; Medical University of South Carolina, Charleston, South Carolina; and the Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Objective: To investigate the optimal gestational age to deliver pregnant people with chronic hypertension to improve perinatal outcomes.
Methods: We conducted a planned secondary analysis of a randomized controlled trial of chronic hypertension treatment to different blood pressure goals. Participants with term, singleton gestations were included.
Concepts for the Development of Person-Centered, Digitally Enabled, Artificial Intelligence-Assisted ARIA Care Pathways (ARIA 2024).
J Allergy Clin Immunol Pract
October 2024
University Clinic of Respiratory and Allergic Diseases, Pulmonary & Allergy Department, Golnik, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- - The traditional healthcare approach often overlooks patients' personal experiences and strengths, focusing mainly on disease treatment. Person-centered care aims to align medical decisions with individual values and preferences, particularly for those with chronic conditions.
- - This paper seeks to enhance care for rhinitis and asthma by developing digital care pathways and incorporating real-world evidence to create a more patient-centered approach.
- - Key components of the review include advancements in mHealth, the integration of artificial intelligence, a novel classification system for airway diseases, and proposals for the ARIA 2024 guidelines, all targeting a sustainable and applicable healthcare model.
Pregnancy Outcomes of Nifedipine Compared With Labetalol for Oral Treatment of Mild Chronic Hypertension.
Obstet Gynecol
July 2024
Departments of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, and University of South Alabama at Mobile, Mobile, Alabama, University of North Carolina at Chapel Hill, Chapel Hill, and Duke University, Durham, North Carolina, University of Pennsylvania and Drexel University College of Medicine, Philadelphia, and Magee Women's Hospital and University of Pittsburgh, Pittsburgh, Pennsylvania, University of Texas at Houston and the Division of Maternal-Fetal Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, and University of Texas Medical Branch, Galveston, Texas, Columbia University and Weill Cornell University, New York, and New York Presbyterian Queens Hospital, Flushing, New York, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, Indiana University, Indianapolis, Indiana, University of Utah and Intermountain Healthcare, Salt Lake City, Utah, UnityPoint Health-Meriter Hospital/Marshfield Clinic, Madison, Wisconsin, Washington University in St. Louis, St. Louis, Missouri, University of Mississippi Medical Center, Jackson, Mississippi, The Ohio State University, Columbus, Ohio, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, Medical College of Wisconsin, Milwaukee, Wisconsin, Yale University, New Haven, Connecticut, University of Colorado, Aurora, and Denver Health, Denver, Colorado, Emory University, Atlanta, Georgia.
Objective: To evaluate maternal and neonatal outcomes by type of antihypertensive used in participants of the CHAP (Chronic Hypertension in Pregnancy) trial.
Methods: We conducted a planned secondary analysis of CHAP, an open-label, multicenter, randomized trial of antihypertensive treatment compared with standard care (no treatment unless severe hypertension developed) in pregnant patients with mild chronic hypertension (blood pressure 140-159/90-104 mm Hg before 20 weeks of gestation) and singleton pregnancies. We performed three comparisons based on medications prescribed at enrollment: labetalol compared with standard care, nifedipine compared with standard care, and labetalol compared with nifedipine.
Validation of the Integrated Palliative Care Outcome Scale (IPOS) in adults with cystic fibrosis.
Pediatr Pulmonol
November 2024
MJHS Institute for Innovation in Palliative Care, New York, New York, USA.
Background: A primary palliative care model for cystic fibrosis (CF) recommends using the Integrated Palliative Care Outcome Scale (IPOS) for screening. Validation of the IPOS is needed.
Methods: This secondary analysis utilized baseline data from a multisite trial of the palliative care model, Improving Life with CF.
Human monoclonal antibodies protect against viral-mediated pneumococcal superinfection.
Front Immunol
June 2024
Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Article Synopsis
- * The study tested a monoclonal antibody cocktail (PhtD3 + 7) for its effectiveness in improving survival rates in models of viral/bacterial co-infections, including influenza A virus (IAV), human metapneumovirus (hMPV), and respiratory syncytial virus (RSV).
- * Results showed that the PhtD3 + 7 cocktail significantly improved survival and reduced bacterial levels in the blood and lungs more effectively than existing antiviral treatments, underscoring its potential as a viable treatment option amid growing antibiotic resistance
2024 RECOVER Guidelines: Monitoring. Evidence and knowledge gap analysis with treatment recommendations for small animal CPR.
J Vet Emerg Crit Care (San Antonio)
June 2024
University Library, University of California, Davis, Davis, California, USA.
Objective: To systematically review evidence on and devise treatment recommendations for patient monitoring before, during, and following CPR in dogs and cats, and to identify critical knowledge gaps.
Design: Standardized, systematic evaluation of literature pertinent to peri-CPR monitoring following Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. Prioritized questions were each reviewed by Evidence Evaluators, and findings were reconciled by Monitoring Domain Chairs and Reassessment Campaign on Veterinary Resuscitation (RECOVER) Co-Chairs to arrive at treatment recommendations commensurate to quality of evidence, risk:benefit relationship, and clinical feasibility.
Diagnosis of Post-Hematopoietic Stem Cell Transplantation Bronchiolitis Obliterans Syndrome in Children: Time for a Rethink?
Transplant Cell Ther
August 2024
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota; Division of Pulmonary Medicine, Masonic Children's Hospital, Minneapolis, Minnesota.
Hematopoietic stem cell transplantation (HSCT) is undertaken in children with the aim of curing a range of malignant and nonmalignant conditions. Unfortunately, pulmonary complications, especially bronchiolitis obliterans syndrome (BOS), are significant sources of morbidity and mortality post-HSCT. Currently, criteria developed by a National Institutes of Health (NIH) working group are used to diagnose BOS in children post-HSCT.
View Article and Find Full Text PDFLung abscess: the non-conservative management: a narrative review.
J Thorac Dis
May 2024
Division of Pulmonary, Critical Care and Sleep Medicine, Georgia Medical College at Augusta University, Augusta, GA, USA.
Background And Objective: Systemic antibiotics are the best treatment options for lung abscesses. However, up to 37% of lung abscesses do not respond to antibiotics and may require additional interventions. Percutaneous transthoracic tube drainage (PTTD), endoscopic catheter drainage (ECD) and surgical resection are additional options available when first line therapy with systemic antibiotics are unsuccessful.
View Article and Find Full Text PDFOne-Month Versus Three-Month Dual-Antiplatelet Therapy in High Bleeding Risk Patients With Chronic Kidney Disease.
Am J Cardiol
August 2024
Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:
Article Synopsis
- Shortening dual-antiplatelet therapy (DAPT) to 1 month after percutaneous coronary intervention (PCI) is effective and safe for high bleeding risk (HBR) patients, regardless of chronic kidney disease (CKD) status.
- A study analyzed data from 3 prospective studies involving 3,286 patients, of whom 43.6% had CKD, comparing outcomes between 1-month and 3-month DAPT.
- Results indicated that both durations had similar rates of death and myocardial infarction after 12 months, with a slight trend for fewer bleeding complications at 1 month compared to 3 months in both CKD and no-CKD groups.
Assessing Right Ventricle Over Time in Patients on Veno-Venous Extracorporeal Membrane Oxygenation: Insights From Serial Echocardiography.
ASAIO J
December 2024
Department of Critical Care Medicine, Mayo Clinic, Jacksonville, Florida.
Extracorporeal membrane oxygenation (ECMO) is often used in acute respiratory distress syndrome (ARDS) with refractory hypoxemia. There is limited literature highlighting the development of right ventricular (RV) failure while on ECMO. We conducted a retrospective multicenter observational study including 70 patients who were placed on veno-venous (VV)-ECMO for respiratory failure at Mayo Clinic, Jacksonville, and Mayo Clinic, Rochester, between January 2018 and June 2022 and had at least two post-ECMO transthoracic echoes.
View Article and Find Full Text PDFClinical Characteristics and Outcomes of Disseminated Strongyloidiasis in the United States-A Multicenter Network Analysis.
Am J Trop Med Hyg
July 2024
Hospital Infantil de México, Ciudad de México, México.
Human strongyloidiasis is a potentially life-threatening parasitic disease among immunocompromised hosts. We aim to determine the factors and mortality associated with disseminated strongyloidiasis. We conducted a U.
View Article and Find Full Text PDFSARS-CoV-2 Vaccination in the First Year After Hematopoietic Cell Transplant or Chimeric Antigen Receptor T-Cell Therapy: A Prospective, Multicenter, Observational Study.
Clin Infect Dis
August 2024
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Background: The optimal timing of vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines after cellular therapy is incompletely understood. The objectives of this study are to determine whether humoral and cellular responses after SARS-CoV-2 vaccination differ if initiated <4 months versus 4-12 months after cellular therapy.
Methods: We conducted a multicenter, prospective, observational study at 30 cancer centers in the United States.
Mean Arterial Pressure and Neonatal Outcomes in Pregnancies Complicated by Mild Chronic Hypertension.
Obstet Gynecol
July 2024
Departments of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, and University of South Alabama at Mobile, Mobile, Alabama, University of North Carolina at Chapel Hill, Chapel Hill, and Duke University, Durham, North Carolina, University of Pennsylvania and Drexel University College of Medicine, Philadelphia, St. Luke's University Health Network, Bethlehem, Magee Women's Hospital and University of Pittsburgh, Pittsburgh, and Lehigh Valley Health Network, Allentown, Pennsylvania, University of Texas at Houston and Baylor College of Medicine and Texas Children's Hospital, Houston, and University of Texas Medical Branch, Galveston, Texas, Columbia University, New York, Winthrop University Hospital, Long Island, and New York Presbyterian Queens Hospital, Flushing, New York, University of Oklahoma, Oklahoma City, Oklahoma, MetroHealth System, Cleveland, The Ohio State University, Columbus, and Wright State University, Fairborn, Ohio, Indiana University, Indianapolis, Indiana, University of Utah Health, Salt Lake City, Utah, Christiana Care Health Services, Newark, Delaware, UnityPoint Health-Meriter Hospital/Marshfield Clinic, Madison, and Medical College of Wisconsin, Milwaukee, Wisconsin, Washington University in St. Louis, St. Louis, Missouri, University of Mississippi Medical Center, Jackson, Mississippi, Yale University, New Haven, Connecticut, University of Colorado, Aurora, and Denver Health Hospital, Denver, Colorado, Emory University, Atlanta, Georgia, University of California, San Francisco, San Francisco, and Stanford University, Stanford, California, Arrowhead Regional Medical Center/Beaumont Hospital, Detroit, Michigan, Virtua Health, Voorhees, New Jersey, Oregon Health & Science University, Portland, Oregon, University of Arkansas for Medical Sciences, Little Rock, Arkansas, University of Tennessee Health Science Center, Memphis, and Vanderbilt University Medical Center, Nashville, Tennessee, Tulane University, New Orleans, Louisiana, University of Kansas Medical Center, Kansas City, Kansas, and Medical University of South Carolina, Charleston, South Carolina; the Center for Women's Reproductive Health, the Department of Biostatistics, and the Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama; Penn State College of Medicine, Hershey, Pennsylvania; Intermountain Health, Salt Lake City, Utah; Ochsner Baptist Medical Center, New Orleans, Louisiana; St. Peters University Hospital and the Department of Obstetrics, Gynecology and Reproductive Health, New Jersey Medical School, Newark, and the Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey; Weill Cornell University, New York, New York; Zuckerberg San Francisco General Hospital, San Francisco, California; TriHealth, Cincinnati Children's Hospital, Cincinnati, Ohio; the Division of Cardiovascular Sciences, NHLBI, Bethesda, Maryland; and the Department of Women's Health, University of Texas at Austin, Austin, Texas.
Objective: To estimate the association between mean arterial pressure during pregnancy and neonatal outcomes in participants with chronic hypertension using data from the CHAP (Chronic Hypertension and Pregnancy) trial.
Methods: A secondary analysis of the CHAP trial, an open-label, multicenter randomized trial of antihypertensive treatment in pregnancy, was conducted. The CHAP trial enrolled participants with mild chronic hypertension (blood pressure [BP] 140-159/90-104 mm Hg) and singleton pregnancies less than 23 weeks of gestation, randomizing them to active treatment (maintained on antihypertensive therapy with a goal BP below 140/90 mm Hg) or standard treatment (control; antihypertensives withheld unless BP reached 160 mm Hg systolic BP or higher or 105 mm Hg diastolic BP or higher).