1 results match your criteria: "Department of Reheumatology and Clinical Immunology[Affiliation]"
Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors.
AIDS
November 2002
Medizinische Universitätsklinik, Department of Reheumatology and Clinical Immunology, Freiburg, Germany.
Background: Some nucleoside analogue reverse transcriptase inhibitors (NRTI) may cause depletion of mitochondrial (mt) DNA in liver by inhibiting polymerase-gamma. mtDNA depletion may contribute to lactic acidosis, steatohepatitis and liver failure.
Objective: To evaluate the long-term mitochondrial toxicity of NRTI combinations.