Drug Development.

Background: The LatAm-FINGERS trial marks a pioneering initiative as the first non-pharmacological clinical trial encompassing participants from 12 Latin American countries, including Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Ecuador, Dominican Republic, Mexico, Peru, Puerto Rico, and Uruguay. This initiative represents a significant advancement in promoting inclusivity and diversity in clinical trial recruitment, particularly in underserved populations.

Method: The LatAm-FINGERS trial is a multicenter randomized clinical trial evaluating a lifestyle intervention tailored for the Latin American population.

Dementia Care Research and Psychosocial Factors.

Background: Aging associates with decreased functional connectivity between brain regions linked to musical rhythm perception. Producing rhythmic music may result in strengthened functional connectivity of these regions, but more evidence is needed to support intervention design. Currently, few studies directly contrast younger and older adults' rhythmic music performance to understand brain-behavior relationships.

Dementia Care Research and Psychosocial Factors.

Background: Early detection of Alzheimer's disease (AD) can improve prognosis, given new anti-amyloid therapies. Both positron emission tomography (PET) and magnetic resonance (MR) imaging biomarkers are currently used (1). 48F-Fluorodeoxyglucose-PET (FDG-PET) can detect neurodegeneration-related hypometabolism but is costly and not easily accessible (2).

Dementia Care Research and Psychosocial Factors.

Background: Dysphagia is an important feature of neurodegenerative diseases and potentially life-threatening in primary progressive aphasia (PPA), but remains poorly characterised in these syndromes. We hypothesised that dysphagia would be more prevalent in nonfluent/agrammatic variant (nfv)PPA than other PPA syndromes, predicted by accompanying motor features and associated with atrophy affecting regions implicated in swallowing control.

Methods: In a retrospective case-control study at our tertiary referral centre, we recruited 56 patients with PPA (21 nfvPPA, 22 semantic variant (sv)PPA, 13 logopenic variant (lv)PPA).

Dementia Care Research and Psychosocial Factors.

Background: In the United States, Black people represent 12% of the total US population and account for 19.3% of dementia cases. Social determinants of health (SDOH) and vascular comorbidities contribute to Black/African Americans having a higher risk of Alzheimer's disease and related dementias (ADRD).

Dementia Care Research and Psychosocial Factors.

Background: LatAm-FINGERS is the first non-pharmacological multicenter randomized clinical trial aimed at preventing cognitive impairment in Latin America. It encompasses twelve countries that collectively represent 45% of the territory in the Americas. Its objective is to reach populations that, despite sharing commonalities such as language, are culturally and economically diverse.

Dementia Care Research and Psychosocial Factors.

Background: Alzheimer's Disease (AD) is the fourth leading cause of death in Puerto Rico (PR), with an estimated prevalence of 14%. Caregivers are an essential part in the management and care of people with AD. Providing care for a person with Alzheimer can change over time and can become a challenge for the caregivers.

Dementia Care Research and Psychosocial Factors.

Background: Personality traits, especially neuroticism, can influence susceptibility to dementia. Although social contact can mitigate stress and risk of dementia, the extent to which social contact can mitigate excess risk associated with neuroticism remains unclear. The objective of study was to investigate changes in neuroticism-associated excess risk of dementia arising from different levels of social contact.

Dementia Care Research and Psychosocial Factors.

Background: Cerebral amyloid angiopathy (CAA) is a significant contributor to hemorrhagic stroke, notably lobar intracerebral hemorrhage (ICH) and convexity subarachnoid hemorrhage (SAH). This study describes the natural occurrence of ICH and SAH events among veterans, including those with AD, within the United States Veterans Affairs Healthcare System (VAHS).

Method: The VAHS database was evaluated to identify ICD-10 codes for ICH (I61.

Dementia Care Research and Psychosocial Factors.

Background: Majority of people living worldwide live in low- and middle- income countries, including sub-Saharan Africa (SSA). Most cognitive assessment batteries for Alzheimer's Disease(AD), are developed in high income countries (HICs), where most international dementia collaborations and data originate. The African Dementia Consortium (AfDC) is a new scientific collaboration network currently participating in the Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the Alzheimer's Disease Sequencing Project (READD-ADSP).

Dementia Care Research and Psychosocial Factors.

Background: African Americans (AA) are underrepresented in Alzheimer's disease (AD) brain donation research, making up approximately 2% of brain donations to the National Alzheimer's Coordinating Center (NACC). Focus groups were conducted to obtain qualitative information to expand upon survey data that was collected previously to gain additional insights into the attitudes of Black∖AA individuals toward brain donation and perceptions of medical research.

Method: A brain donation focus group facilitator guide was created based upon earlier survey findings.

Dementia Care Research and Psychosocial Factors.

Background: Black/African American (AA) caregivers of patients with Alzheimer's disease (AD) and related disorders can play a critical role in maintaining patient health. AD caregivers who face economic challenges may have less access to resources that may reduce caregiver burden they experience. The North Carolina Department of Commerce ranks the state's 100 counties based on economic well-being and assigns the most distressed counties as Tier 1, and least distressed as Tier 3.

Dementia Care Practice.

Background: Guidelines that provide current and comprehensive overviews of the evidence quality and effectiveness of interventions that address behaviours and psychological symptoms associated with dementia (BPSD, also known as Changed Behaviours) are needed for clinicians, professional care staff and family care partners. With funding provided by the Australian Government Department of Health and Aged Care, we aimed to update the existing Behaviour Management: A Guide to Good Practice, Managing Behavioural and Psychological Symptoms of Dementia (2012) text and app resources to reflect findings from the most recent literature and other sources.

Methods: We systematically searched PubMed, Medline, Embase, and PsycINFO for psychosocial and environmental and biological and pharmacological interventions published between 2012-2021 that addressed BPSD.

Prenatal visualization of the fetal uterus in routine 2D ultrasound examination.

Objective: To establish a new technique to easily identify the fetal cervix-uterus complex in normal female fetuses from 20 to 40 weeks of gestation.

Material And Methods: The study was performed in routine examination in normal fetuses by two observers. Twenty-five consecutive cases per gestational week were assessed between 20 and 40 weeks.

Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, -Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues.

Multiomics analysis of single tissue sections using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) provides comprehensive molecular insights. However, optimizing tissue sample preparation for MALDI-MSI to achieve high sensitivity and reproducibility for various biomolecules, such as lipids, -glycans, and tryptic peptides, presents a significant challenge. This study introduces a robust and reproducible protocol for the comprehensive sequential analysis of the latter molecules using MALDI-MSI in fresh-frozen rodent brain tissue samples.

Dementia Care Practice.

Background: Dementia syndromes are chronic health conditions that lead to significant cognitive decline and functional impairment, including acts of civil life. Concerning the latter, a guardianship petition maybe needed when patients or family are at risk.

Methods: Retrospective cross-sectional study of documentary research on 72 electronical guardianship proceedings involving adults with dementia.

Dementia Care Practice.

Objective: Few studies have investigated trajectories in care among patients with Alzheimer's Disease (AD), especially Veterans who experience a unique set of AD risk factors and challenges in access to AD immunotherapy in the Veterans Affairs Healthcare System (VAHS) of the United States.

Methods: We analyzed trajectories in care based on electronic health records (EHR) among Veterans who were assessed for AD based on ICD-10 coding within the VAHS between Oct 2015 and Jan 2024. Among Veterans with an ICD-10 code for AD in the VAHS, we examined frequency distributions of clinical visits by physician specialty (primary care, neurologist, geriatrician, psychiatrist, and other specialties) where the initial AD ICD-10 coding was recorded.

Technology and Dementia Preconference.

Background: Timely diagnosis of mild cognitive impairment (MCI) in Alzheimer's disease (AD) is crucial for early interventions, but its implementation is often challenging due to the complexity and time burden of required cognitive assessments. Remote unsupervised self-testing of cognition can potentially addres this health care challenge. We conducted the to date largest evaluation of feasibility and experienced added value of unsupervised digital remote assessment in primary and specialized health care in Germany.

Technology and Dementia Preconference.

Background: Cognitive assessment should be actively incorporated into the clinical evaluation of patients in Primary Health Care (PHC) settings. This is because of the imminent demand with the changing demographics especially in low- and middle-income countries (LMICs) concerning dementia and Alzheimer's disease.

Method: A cross-sectional mixed-method descriptive study was conducted to evaluate the useability and performance of a tablet-based cognitive assessment tool (TabCAT) for use in geriatric primary healthcare settings in southeast Nigeria.

Dementia Care Practice.

Background: Data-driven criteria for DNA testing were implemented in routine care of Alzheimer Center Amsterdam. We aimed to explore patients' perspectives and considerations regarding their decision to (not) be tested for a monogenic cause of their disease.

Methods: In this mixed method study, 150 of 519 new patients visiting Alzheimer Center Amsterdam who fulfilled the criteria were offered DNA-diagnostics: 86(57%) accepted, 64(43%) did not.

Technology and Dementia Preconference.

Background: Many outcome measures used in AD clinical trials require clinic visits and are paper based, making them infrequent and burdensome 'snapshots', subject to rater bias. A consortium of 10 pharma companies came together with Cumulus Neuroscience to design a solution for frequent, objective, real-world measurement across a range of domains. We present a study that examined the feasibility of asking patients with mild dementia to use the neuroassessment platform repeatedly at home for one year.

Evaluating the implementation of online research training and mentorship among early-career family physicians in sub-Saharan Africa.

Background: Research is needed to improve the performance of primary health care. In Africa, few family physicians conduct research, and therefore an online research training and mentorship programme was developed to build research capacity amongst novice and early career researchers.

Aim: To evaluate the implementation of the AfriWon Research Collaborative (ARC) training and e-mentorship programme in sub-Saharan Africa.

Evaluation of Depression and Cognitive Status in Geriatric Patients Undergoing Orthopedic Surgery.

Purpose Of The Study: Cognitive disorders are common in geriatric surgical patients We conducted a study to evaluate depression and cognitive behavior in geriatric patients undergoing orthopedic surgery.

Material And Methods: This descriptive cross-sectional study was conducted at a university hospital in Turkey, involving 262 elderly patients who underwent orthopedic surgeries. Data were collected using The Patient Information Form, Standardized Mini-Mental Test, and Geriatric Depression Scale.

PTSD and challenges among older Chinese in Shenzhen during COVID-19 pandemic: Trust in authority and medical professionals as moderators.

Aim: This research aimed to comprehensively explore the impact of diverse challenges encountered by older adults on the development of post-traumatic stress disorder (PTSD). It delved into how these effects vary depending on individuals' levels of trust in authority and medical professionals, providing a nuanced understanding of the interplay between external challenges, personal trust, and mental health outcomes in the older population.

Background: The COVID-19 pandemic has imposed significant hardships, particularly on the ageing population, with potential psychological repercussions such as PTSD.

Exploring the association between familial hemiplegic migraine genes (, and ) with migraine and epilepsy: A UK Biobank exome-wide association study.

Background: Familial hemiplegic migraine (FHM) types 1-3 are associated with protein-altering genetic variants in , and , respectively. These genes have also been linked to epilepsy. Previous studies primarily focused on phenotypes, examining genetic variants in individuals with characteristic FHM symptoms.