Classifying, recognizing, and troubleshooting errors in magnetic resonance imaging (MRI)-guided breast biopsies.

MRI-guided biopsies can generate challenging scenarios. Errors can occur for many reasons, both preprocedural and intraprocedural. Radiology errors have been studied for many years, originally classified by Renfrew in 1992 and revised in 2014 by Kim and Mansfield.

F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition.

Purpose: Hypoxia is a common characteristic of many tumor microenvironments, and it has been shown to promote suppression of antitumor immunity. Despite strong biological rationale, longitudinal correlation of hypoxia and response to immunotherapy has not been investigated.

Experimental Design: In this study, we probed the tumor and its surrounding microenvironment with F-FMISO PET imaging to noninvasively quantify tumor hypoxia prior to and during PD-1 and CTLA-4 checkpoint blockade in preclinical models of breast and colon cancer.