Influence of 17-beta-estradiol on cerebrovascular impedance during menstrual cycle in women.

Numerous experimental studies showed that estrogen alters diameters of cerebral arteries by modifying production of vasoactive substances. In this study, we address a question whether increased concentration of 17-beta-estradiol (E2) during a typical menstrual cycle of young, healthy women influences cerebrovascular impedance, as measured with Doppler pulsatility index (PI) in the common (CCA), internal (ICA), and external (ECA) carotid arteries using duplex Doppler sonography. PI was determined and correlated with plasma E2 concentration in 14 women (ages 23-25) throughout their menstrual cycle.