15 results match your criteria: "Department of Radiology University of Washington Seattle[Affiliation]"
Background Acute COVID-19-related myocardial, pulmonary, and vascular pathology and how these relate to each other remain unclear. To our knowledge, no studies have used complementary imaging techniques, including molecular imaging, to elucidate this. We used multimodality imaging and biochemical sampling in vivo to identify the pathobiology of acute COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- This research examines how image texture analysis (radiomics) from FDG-PET/CT scans can reveal tumor characteristics that may help predict survival outcomes in patients with untreated diffuse large B-cell lymphoma (DLBCL).
- A random forest model that incorporates quantitative image texture features and clinical risk factors was created and tested against the conventional international prognostic index (IPI) to improve predictions on patient survival.
- The findings suggest that combining PET-derived texture analysis with traditional clinical factors can better identify high-risk patient groups, leading to more accurate predictions of progression-free and overall survival rates than using IPI alone.
Background: Patients with cutaneous T-cell lymphoma (CTCL) often have indolent but symptomatic disease.
Objective: Assessment of the health-related quality of life (HRQoL) of patients with CTCL.
Methods: Cross-sectional survey study.
Article Synopsis
- * Results showed a high prevalence of CPR-related injuries (81%), with 14% of patients presenting critical injuries, and those with CPR injuries were generally older but had comparable survival rates to those without injuries.
- * The study found that mechanical CPR systems were linked to more frequent sternal fractures, though they did not significantly improve survival outcomes, indicating the need for further exploration of CT's diagnostic utility in post-resuscitation care
Background An artificial intelligence vessel segmentation tool, Fully Automated and Robust Analysis Technique for Popliteal Artery Evaluation (FRAPPE), was used to analyze a large databank of popliteal arteries imaged through the OAI (Osteoarthritis Initiative) to study the impact of atherosclerosis risk factors on vessel dimensions and characterize remodeling patterns. Methods and Results Magnetic resonance images from 4668 subjects contributing 9189 popliteal arteries were analyzed using FRAPPE. Age ranged from 45 to 79 years (median, 61), and 58% were women.
View Article and Find Full Text PDFCerebral ischemia is a major cause of death in both neonates and adults, and currently has no cure. Nanotechnology represents one promising area of therapeutic development for cerebral ischemia due to the ability of nanoparticles to overcome biological barriers in the brain. ex vivo injury models have emerged as a high-throughput alternative that can recapitulate disease processes and enable nanoscale probing of the brain microenvironment.
View Article and Find Full Text PDFObjective: Autosomal-dominant familial Alzheimer disease (AD) is caused by by variants in presenilin 1 (), presenilin 2 (), and amyloid precursor protein (). Previously, we reported a rare frameshift variant in an early-onset AD case (PSEN2 p.K115Efs*11).
View Article and Find Full Text PDFAtherosclerosis in stroke-related vascular beds and stroke risk: A 3-D MR vessel wall imaging study.
Ann Clin Transl Neurol
December 2018
Objectives: To investigate the characteristics of atherosclerotic plaques in stroke-related vascular beds and their relationship with stroke using three-dimensional magnetic resonance (MR) vessel wall imaging.
Methods: Fifty-two symptomatic patients (mean age: 56.3 ± 13.
T1-Hyperintense Plaques on Intracranial-versus-Extracranial Vessel Wall MRI.
AJNR Am J Neuroradiol
January 2019
Department of Radiology University of Washington Seattle, Washington.
A CMOS Front-End Interface ASIC for SiPM-based Positron Emission Tomography Imaging Systems.
IEEE Biomed Circuits Syst Conf
October 2017
Department of Radiology University of Washington Seattle, USA.
A current-mode interface chip for Silicon Photomultiplier (SiPM) array based positron emission tomography (PET) imaging front-ends is described. The circuit uses a high-speed current amplifier with a low input impedance, to minimize signal loss at the SiPM amplifier interface. To reduce the impact of dark noise, a novel high-speed threshold detection/comparator circuit is used to remove unwanted noise events.
View Article and Find Full Text PDFObjective: This study sought to investigate the relationship of atherosclerosis between intracranial and extracranial carotid arteries using three-dimensional multicontrast magnetic resonance (MR) vessel wall imaging.
Methods: Patients with recent cerebrovascular symptoms in anterior circulation were recruited and underwent MR vessel wall imaging for intracranial and extracranial carotid arteries. The plaque burden, including maximum wall thickness (Max WT) and stenosis, and presence of intraplaque hemorrhage (IPH) were assessed.
Introduction: Resting-state connectivity patterns have been observed in humans and other mammal species, and can be recorded using a variety of different technologies. Functional connectivity has been previously compared between species using resting-state fMRI, but not in electrophysiological studies.
Methods: We compared connectivity with implanted electrodes in humans (electrocorticography) to macaques and sheep (microelectrocorticography), which are capable of recording neural data at high frequencies with spatial precision.