1 results match your criteria: "Department of Public Health Erasmus MC-University Medical Center Rotterdam[Affiliation]"
Subgroup analysis and covariate adjustment in randomized clinical trials of traumatic brain injury: a systematic review.
Neurosurgery
December 2005
Center for Clinical Decision Sciences, Department of Public Health Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Objective: Few randomized clinical trials (RCTs) in the field of traumatic brain injury (TBI) have shown a significant treatment benefit. We critically reviewed the use of two types of secondary analyses, covariate adjustment and subgroup analysis, which are common in TBI trials.
Methods: We performed a systematic review of therapeutic phase III RCTs, including adult patients with acute, moderate-to-severe TBI.