2 results match your criteria: "Department of Psychology University of Arizona Tucson Arizona USA.[Affiliation]"
Introduction: We examined the relationship between sedentary behavior (SB), moderate-to-vigorous physical activity (MVPA), and white matter hyperintensity (WMH) volumes, a common magnetic resonance imaging (MRI) marker associated with risk of neurodegenerative disease in middle-aged to older adults.
Methods: We used data from the UK Biobank ( = 14,415; 45 to 81 years) that included accelerometer-derived measures of SB and MVPA, and WMH volumes from MRI.
Results: Both MVPA and SB were associated with WMH volumes (β= -0.
Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease.
Alzheimers Dement (Amst)
October 2023
Article Synopsis
- This study investigated the effectiveness of plasma glial fibrillary acidic protein (GFAP) as a biomarker for cognitive impairment in Alzheimer's disease (AD) compared to other biomarkers like neurofilament light chain (NfL) and phosphorylated tau (p-tau).
- The research analyzed plasma samples from 567 participants and correlated GFAP levels with cognitive functions and dementia severity, finding that GFAP was significantly more effective in differentiating between normal cognition and AD dementia or mild cognitive impairment.
- While higher GFAP levels were linked to worse cognitive performance and dementia symptoms, it specifically predicted memory decline over time but did not indicate progression to mild cognitive impairment or dementia.